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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
eIF2B-epsilon
Full Name:
Translation initiation factor eIF-2B subunit epsilon
Alias:
EI2BE; EIF-2B; eIF-2B GDP-GTP exchange factor; EIF2B5; EIF2BE; EIF2Bepsilon; eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; translation initiation factor eIF-2B epsilon subunit
Type:
Protein synthesis protein
Mass (Da):
80380
Number AA:
721
UniProt ID:
Q13144
International Prot ID:
IPI00011898
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005851
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005085
GO:0016740
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0014002
GO:0042552
GO:0032057
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
P
P
G
V
V
V
S
R
A
N
K
R
S
G
Site 2
S20
V
S
R
A
N
K
R
S
G
A
G
P
G
G
S
Site 3
S27
S
G
A
G
P
G
G
S
G
G
G
G
A
R
G
Site 4
S60
D
R
R
F
F
P
I
S
K
D
Q
P
R
V
L
Site 5
T115
K
S
K
W
C
R
P
T
S
L
N
V
V
R
I
Site 6
S130
I
T
S
E
L
Y
R
S
L
G
D
V
L
R
D
Site 7
S179
R
K
L
E
K
N
V
S
V
M
T
M
I
F
K
Site 8
T182
E
K
N
V
S
V
M
T
M
I
F
K
E
S
S
Site 9
S188
M
T
M
I
F
K
E
S
S
P
S
H
P
T
R
Site 10
S189
T
M
I
F
K
E
S
S
P
S
H
P
T
R
C
Site 11
S191
I
F
K
E
S
S
P
S
H
P
T
R
C
H
E
Site 12
T218
R
V
L
H
F
Q
K
T
Q
G
L
R
R
F
A
Site 13
S229
R
R
F
A
F
P
L
S
L
F
Q
G
S
S
D
Site 14
S235
L
S
L
F
Q
G
S
S
D
G
V
E
V
R
Y
Site 15
Y242
S
D
G
V
E
V
R
Y
D
L
L
D
C
H
I
Site 16
Y266
L
F
T
D
N
F
D
Y
Q
T
R
D
D
F
V
Site 17
S301
K
E
Y
G
A
R
V
S
N
L
H
M
Y
S
A
Site 18
Y319
D
V
I
R
R
W
V
Y
P
L
T
P
E
A
N
Site 19
T322
R
R
W
V
Y
P
L
T
P
E
A
N
F
T
D
Site 20
T328
L
T
P
E
A
N
F
T
D
S
T
T
Q
S
C
Site 21
S330
P
E
A
N
F
T
D
S
T
T
Q
S
C
T
H
Site 22
T331
E
A
N
F
T
D
S
T
T
Q
S
C
T
H
S
Site 23
T332
A
N
F
T
D
S
T
T
Q
S
C
T
H
S
R
Site 24
S334
F
T
D
S
T
T
Q
S
C
T
H
S
R
H
N
Site 25
T336
D
S
T
T
Q
S
C
T
H
S
R
H
N
I
Y
Site 26
Y343
T
H
S
R
H
N
I
Y
R
G
P
E
V
S
L
Site 27
S411
A
G
A
Q
I
H
Q
S
L
L
C
D
N
A
E
Site 28
T424
A
E
V
K
E
R
V
T
L
K
P
R
S
V
L
Site 29
S433
K
P
R
S
V
L
T
S
Q
V
V
V
G
P
N
Site 30
S450
L
P
E
G
S
V
I
S
L
H
P
P
D
A
E
Site 31
S466
D
E
D
D
G
E
F
S
D
D
S
G
A
D
Q
Site 32
S469
D
G
E
F
S
D
D
S
G
A
D
Q
E
K
D
Site 33
S525
K
I
N
M
E
E
E
S
E
S
E
S
E
Q
S
Site 34
S527
N
M
E
E
E
S
E
S
E
S
E
Q
S
M
D
Site 35
S529
E
E
E
S
E
S
E
S
E
Q
S
M
D
S
E
Site 36
S532
S
E
S
E
S
E
Q
S
M
D
S
E
E
P
D
Site 37
S535
E
S
E
Q
S
M
D
S
E
E
P
D
S
R
G
Site 38
S540
M
D
S
E
E
P
D
S
R
G
G
S
P
Q
M
Site 39
S544
E
P
D
S
R
G
G
S
P
Q
M
D
D
I
K
Site 40
T560
F
Q
N
E
V
L
G
T
L
Q
R
G
K
E
E
Site 41
S570
R
G
K
E
E
N
I
S
C
D
N
L
V
L
E
Site 42
Y583
L
E
I
N
S
L
K
Y
A
Y
N
I
S
L
K
Site 43
S610
F
P
L
Q
Q
M
D
S
P
L
D
S
S
R
Y
Site 44
S614
Q
M
D
S
P
L
D
S
S
R
Y
C
A
L
L
Site 45
Y635
W
S
P
V
F
R
N
Y
I
K
R
A
A
D
H
Site 46
S683
L
A
E
E
T
I
L
S
W
F
S
Q
R
D
T
Site 47
S686
E
T
I
L
S
W
F
S
Q
R
D
T
T
D
K
Site 48
T690
S
W
F
S
Q
R
D
T
T
D
K
G
Q
Q
L
Site 49
T691
W
F
S
Q
R
D
T
T
D
K
G
Q
Q
L
R
Site 50
S717
L
K
E
A
E
E
E
S
S
E
D
D
_
_
_
Site 51
S718
K
E
A
E
E
E
S
S
E
D
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation