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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPS1
Full Name:
COP9 signalosome complex subunit 1
Alias:
COPS1; CSN1; G protein pathway suppressor 1; GPS1 protein; MFH protein
Type:
G protein regulator, misc.
Mass (Da):
55537
Number AA:
491
UniProt ID:
Q13098
International Prot ID:
IPI00414289
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0008180
Uniprot
OncoNet
Molecular Function:
GO:0005095
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0007049
GO:0000188
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y35
Q
N
A
P
D
V
N
Y
V
V
E
N
P
S
L
Site 2
Y47
P
S
L
D
L
E
Q
Y
A
A
S
Y
S
G
L
Site 3
S52
E
Q
Y
A
A
S
Y
S
G
L
M
R
I
E
R
Site 4
T85
A
L
S
F
V
Q
R
T
F
N
V
D
M
Y
E
Site 5
Y91
R
T
F
N
V
D
M
Y
E
E
I
H
R
K
L
Site 6
S99
E
E
I
H
R
K
L
S
E
A
T
R
S
S
L
Site 7
T102
H
R
K
L
S
E
A
T
R
S
S
L
R
E
L
Site 8
S104
K
L
S
E
A
T
R
S
S
L
R
E
L
Q
N
Site 9
S105
L
S
E
A
T
R
S
S
L
R
E
L
Q
N
A
Site 10
S119
A
P
D
A
I
P
E
S
G
V
E
P
P
A
L
Site 11
T147
L
K
L
E
K
L
D
T
D
L
K
N
Y
K
G
Site 12
S160
K
G
N
S
I
K
E
S
I
R
R
G
H
D
D
Site 13
Y172
H
D
D
L
G
D
H
Y
L
D
C
G
D
L
S
Site 14
Y185
L
S
N
A
L
K
C
Y
S
R
A
R
D
Y
C
Site 15
Y191
C
Y
S
R
A
R
D
Y
C
T
S
A
K
H
V
Site 16
T193
S
R
A
R
D
Y
C
T
S
A
K
H
V
I
N
Site 17
S220
Q
N
W
S
H
V
L
S
Y
V
S
K
A
E
S
Site 18
Y221
N
W
S
H
V
L
S
Y
V
S
K
A
E
S
T
Site 19
S223
S
H
V
L
S
Y
V
S
K
A
E
S
T
P
E
Site 20
S227
S
Y
V
S
K
A
E
S
T
P
E
I
A
E
Q
Site 21
T228
Y
V
S
K
A
E
S
T
P
E
I
A
E
Q
R
Site 22
S240
E
Q
R
G
E
R
D
S
Q
T
Q
A
I
L
T
Site 23
T242
R
G
E
R
D
S
Q
T
Q
A
I
L
T
K
L
Site 24
Y263
A
E
L
A
A
R
K
Y
K
Q
A
A
K
C
L
Site 25
T300
G
G
L
C
A
L
A
T
F
D
R
Q
E
L
Q
Site 26
S312
E
L
Q
R
N
V
I
S
S
S
S
F
K
L
F
Site 27
S314
Q
R
N
V
I
S
S
S
S
F
K
L
F
L
E
Site 28
Y334
R
D
I
I
F
K
F
Y
E
S
K
Y
A
S
C
Site 29
Y338
F
K
F
Y
E
S
K
Y
A
S
C
L
K
M
L
Site 30
S340
F
Y
E
S
K
Y
A
S
C
L
K
M
L
D
E
Site 31
Y357
R
N
R
A
L
I
Q
Y
F
S
P
Y
V
S
A
Site 32
Y366
A
P
H
V
R
T
L
Y
T
Q
I
R
N
R
A
Site 33
Y377
R
N
R
A
L
I
Q
Y
F
S
P
Y
V
S
A
Site 34
Y381
L
I
Q
Y
F
S
P
Y
V
S
A
D
M
H
R
Site 35
S419
L
I
S
A
R
V
D
S
H
S
K
I
L
Y
A
Site 36
S421
S
A
R
V
D
S
H
S
K
I
L
Y
A
R
D
Site 37
Y425
D
S
H
S
K
I
L
Y
A
R
D
V
D
Q
R
Site 38
S433
A
R
D
V
D
Q
R
S
T
T
F
E
K
S
L
Site 39
T434
R
D
V
D
Q
R
S
T
T
F
E
K
S
L
L
Site 40
T435
D
V
D
Q
R
S
T
T
F
E
K
S
L
L
M
Site 41
S439
R
S
T
T
F
E
K
S
L
L
M
G
K
E
F
Site 42
S468
R
N
Q
I
H
V
K
S
P
P
R
E
G
S
Q
Site 43
S474
K
S
P
P
R
E
G
S
Q
G
E
L
T
P
A
Site 44
T479
E
G
S
Q
G
E
L
T
P
A
N
S
Q
S
R
Site 45
S483
G
E
L
T
P
A
N
S
Q
S
R
M
S
T
N
Site 46
S485
L
T
P
A
N
S
Q
S
R
M
S
T
N
M
_
Site 47
S488
A
N
S
Q
S
R
M
S
T
N
M
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation