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Updated November 2019
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Protein Info
Short Name:
ACACA
Full Name:
Acetyl-CoA carboxylase 1
Alias:
ACAC; ACC; ACC1; ACCA; ACC-alpha; Acetyl-Coenzyme A carboxylase alpha; COA1
Type:
EC 6.4.1.2; Ligase; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid biosynthesis
Mass (Da):
265554
Number AA:
2346
UniProt ID:
Q13085
International Prot ID:
IPI00011569
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003989
GO:0009374
PhosphoSite+
KinaseNET
Biological Process:
GO:0006633
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
E
P
S
P
L
A
Q
P
L
E
Site 2
S17
P
L
E
L
N
Q
H
S
R
F
I
I
G
S
V
Site 3
S23
H
S
R
F
I
I
G
S
V
S
E
D
N
S
E
Site 4
S25
R
F
I
I
G
S
V
S
E
D
N
S
E
D
E
Site 5
S29
G
S
V
S
E
D
N
S
E
D
E
I
S
N
L
Site 6
S34
D
N
S
E
D
E
I
S
N
L
V
K
L
D
L
Site 7
S48
L
L
E
E
K
E
G
S
L
S
P
A
S
V
G
Site 8
S50
E
E
K
E
G
S
L
S
P
A
S
V
G
S
D
Site 9
S53
E
G
S
L
S
P
A
S
V
G
S
D
T
L
S
Site 10
S56
L
S
P
A
S
V
G
S
D
T
L
S
D
L
G
Site 11
T58
P
A
S
V
G
S
D
T
L
S
D
L
G
I
S
Site 12
S60
S
V
G
S
D
T
L
S
D
L
G
I
S
S
L
Site 13
S77
G
L
A
L
H
I
R
S
S
M
S
G
L
H
L
Site 14
S78
L
A
L
H
I
R
S
S
M
S
G
L
H
L
V
Site 15
S80
L
H
I
R
S
S
M
S
G
L
H
L
V
K
Q
Site 16
S96
R
D
R
K
K
I
D
S
Q
R
D
F
T
V
A
Site 17
T101
I
D
S
Q
R
D
F
T
V
A
S
P
A
E
F
Site 18
S104
Q
R
D
F
T
V
A
S
P
A
E
F
V
T
R
Site 19
Y142
R
S
I
R
R
W
S
Y
E
M
F
R
N
E
R
Site 20
T158
I
R
F
V
V
M
V
T
P
E
D
L
K
A
N
Site 21
Y175
Y
I
K
M
A
D
H
Y
V
P
V
P
G
G
P
Site 22
Y187
G
G
P
N
N
N
N
Y
A
N
V
E
L
I
L
Site 23
T257
A
Q
T
A
G
I
P
T
L
P
W
S
G
S
G
Site 24
S261
G
I
P
T
L
P
W
S
G
S
G
L
R
V
D
Site 25
S263
P
T
L
P
W
S
G
S
G
L
R
V
D
W
Q
Site 26
Y286
L
N
V
P
Q
E
L
Y
E
K
G
Y
V
K
D
Site 27
Y290
Q
E
L
Y
E
K
G
Y
V
K
D
V
D
D
G
Site 28
Y306
Q
A
A
E
E
V
G
Y
P
V
M
I
K
A
S
Site 29
S313
Y
P
V
M
I
K
A
S
E
G
G
G
G
K
G
Site 30
S355
V
M
R
L
A
K
Q
S
R
H
L
E
V
Q
I
Site 31
S372
D
Q
Y
G
N
A
I
S
L
F
G
R
D
C
S
Site 32
S379
S
L
F
G
R
D
C
S
V
Q
R
R
H
Q
K
Site 33
Y417
K
L
A
K
M
V
G
Y
V
S
A
G
T
V
E
Site 34
Y425
V
S
A
G
T
V
E
Y
L
Y
S
Q
D
G
S
Site 35
Y427
A
G
T
V
E
Y
L
Y
S
Q
D
G
S
F
Y
Site 36
S428
G
T
V
E
Y
L
Y
S
Q
D
G
S
F
Y
F
Site 37
S432
Y
L
Y
S
Q
D
G
S
F
Y
F
L
E
L
N
Site 38
Y434
Y
S
Q
D
G
S
F
Y
F
L
E
L
N
P
R
Site 39
T449
L
Q
V
E
H
P
C
T
E
M
V
A
D
V
N
Site 40
Y480
I
K
D
I
R
M
M
Y
G
V
S
P
W
G
D
Site 41
S488
G
V
S
P
W
G
D
S
P
I
D
F
E
D
S
Site 42
S495
S
P
I
D
F
E
D
S
A
H
V
P
C
P
R
Site 43
T511
H
V
I
A
A
R
I
T
S
E
N
P
D
E
G
Site 44
S512
V
I
A
A
R
I
T
S
E
N
P
D
E
G
F
Site 45
S523
D
E
G
F
K
P
S
S
G
T
V
Q
E
L
N
Site 46
Y540
S
N
K
N
V
W
G
Y
F
S
V
A
A
A
G
Site 47
S572
E
N
R
E
E
A
I
S
N
M
V
V
A
L
K
Site 48
T589
S
I
R
G
D
F
R
T
T
V
E
Y
L
I
K
Site 49
S602
I
K
L
L
E
T
E
S
F
Q
M
N
R
I
D
Site 50
T610
F
Q
M
N
R
I
D
T
G
W
L
D
R
L
I
Site 51
S647
A
D
V
S
L
R
N
S
V
S
N
F
L
H
S
Site 52
S649
V
S
L
R
N
S
V
S
N
F
L
H
S
L
E
Site 53
S654
S
V
S
N
F
L
H
S
L
E
R
G
Q
V
L
Site 54
S692
V
T
R
Q
S
P
N
S
Y
V
V
I
M
N
G
Site 55
Y693
T
R
Q
S
P
N
S
Y
V
V
I
M
N
G
S
Site 56
S717
S
D
G
G
L
L
L
S
Y
D
G
S
S
Y
T
Site 57
Y718
D
G
G
L
L
L
S
Y
D
G
S
S
Y
T
T
Site 58
S721
L
L
L
S
Y
D
G
S
S
Y
T
T
Y
M
K
Site 59
S722
L
L
S
Y
D
G
S
S
Y
T
T
Y
M
K
E
Site 60
T725
Y
D
G
S
S
Y
T
T
Y
M
K
E
E
V
D
Site 61
Y726
D
G
S
S
Y
T
T
Y
M
K
E
E
V
D
R
Site 62
Y734
M
K
E
E
V
D
R
Y
R
I
T
I
G
N
K
Site 63
T737
E
V
D
R
Y
R
I
T
I
G
N
K
T
C
V
Site 64
T742
R
I
T
I
G
N
K
T
C
V
F
E
K
E
N
Site 65
S752
F
E
K
E
N
D
P
S
V
M
R
S
P
S
A
Site 66
S756
N
D
P
S
V
M
R
S
P
S
A
G
K
L
I
Site 67
S758
P
S
V
M
R
S
P
S
A
G
K
L
I
Q
Y
Site 68
Y765
S
A
G
K
L
I
Q
Y
I
V
E
D
G
G
H
Site 69
Y801
V
E
S
G
C
I
H
Y
V
K
R
P
G
A
A
Site 70
S835
Q
A
E
L
H
T
G
S
L
P
R
I
Q
S
T
Site 71
S841
G
S
L
P
R
I
Q
S
T
A
L
R
G
E
K
Site 72
Y855
K
L
H
R
V
F
H
Y
V
L
D
N
L
V
N
Site 73
Y867
L
V
N
V
M
N
G
Y
C
L
P
D
P
F
F
Site 74
T888
W
V
E
R
L
M
K
T
L
R
D
P
S
L
P
Site 75
S893
M
K
T
L
R
D
P
S
L
P
L
L
E
L
Q
Site 76
S907
Q
D
I
M
T
S
V
S
G
R
I
P
P
N
V
Site 77
S917
I
P
P
N
V
E
K
S
I
K
K
E
M
A
Q
Site 78
Y925
I
K
K
E
M
A
Q
Y
A
S
N
I
T
S
V
Site 79
S947
Q
I
A
N
I
L
D
S
H
A
A
T
L
N
R
Site 80
T951
I
L
D
S
H
A
A
T
L
N
R
K
S
E
R
Site 81
S956
A
A
T
L
N
R
K
S
E
R
E
V
F
F
M
Site 82
S977
Q
L
V
Q
R
Y
R
S
G
I
R
G
H
M
K
Site 83
Y994
V
M
D
L
L
R
Q
Y
L
R
V
E
T
Q
F
Site 84
T999
R
Q
Y
L
R
V
E
T
Q
F
Q
N
G
H
Y
Site 85
S1019
A
L
R
E
E
N
K
S
D
M
N
T
V
L
N
Site 86
T1023
E
N
K
S
D
M
N
T
V
L
N
Y
I
F
S
Site 87
T1042
T
K
K
N
L
L
V
T
M
L
I
D
Q
L
C
Site 88
T1054
Q
L
C
G
R
D
P
T
L
T
D
E
L
L
N
Site 89
T1056
C
G
R
D
P
T
L
T
D
E
L
L
N
I
L
Site 90
T1064
D
E
L
L
N
I
L
T
E
L
T
Q
L
S
K
Site 91
S1092
L
I
A
S
H
L
P
S
Y
E
L
R
H
N
Q
Site 92
Y1093
I
A
S
H
L
P
S
Y
E
L
R
H
N
Q
V
Site 93
S1102
L
R
H
N
Q
V
E
S
I
F
L
S
A
I
D
Site 94
Y1139
D
V
L
P
N
F
F
Y
H
S
N
Q
V
V
R
Site 95
Y1158
E
V
Y
V
R
R
A
Y
I
A
Y
E
L
N
S
Site 96
Y1161
V
R
R
A
Y
I
A
Y
E
L
N
S
V
Q
H
Site 97
T1186
E
F
Q
F
M
L
P
T
S
H
P
N
R
G
N
Site 98
T1196
P
N
R
G
N
I
P
T
L
N
R
M
S
F
S
Site 99
S1201
I
P
T
L
N
R
M
S
F
S
S
N
L
N
H
Site 100
Y1209
F
S
S
N
L
N
H
Y
G
M
T
H
V
A
S
Site 101
T1212
N
L
N
H
Y
G
M
T
H
V
A
S
V
S
D
Site 102
S1216
Y
G
M
T
H
V
A
S
V
S
D
V
L
L
D
Site 103
S1218
M
T
H
V
A
S
V
S
D
V
L
L
D
N
S
Site 104
S1225
S
D
V
L
L
D
N
S
F
T
P
P
C
Q
R
Site 105
T1227
V
L
L
D
N
S
F
T
P
P
C
Q
R
M
G
Site 106
S1238
Q
R
M
G
G
M
V
S
F
R
T
F
E
D
F
Site 107
S1257
D
E
V
M
G
C
F
S
D
S
P
P
Q
S
P
Site 108
S1259
V
M
G
C
F
S
D
S
P
P
Q
S
P
T
F
Site 109
S1263
F
S
D
S
P
P
Q
S
P
T
F
P
E
A
G
Site 110
T1265
D
S
P
P
Q
S
P
T
F
P
E
A
G
H
T
Site 111
S1273
F
P
E
A
G
H
T
S
L
Y
D
E
D
K
V
Site 112
Y1275
E
A
G
H
T
S
L
Y
D
E
D
K
V
P
R
Site 113
T1312
A
A
M
F
R
E
F
T
Q
Q
N
K
A
T
L
Site 114
T1328
D
H
G
I
R
R
L
T
F
L
V
A
Q
K
D
Site 115
Y1342
D
F
R
K
Q
V
N
Y
E
V
D
R
R
F
H
Site 116
T1357
R
E
F
P
K
F
F
T
F
R
A
R
D
K
F
Site 117
Y1370
K
F
E
E
D
R
I
Y
R
H
L
E
P
A
L
Site 118
Y1404
A
N
H
K
M
H
L
Y
L
G
A
A
K
V
E
Site 119
S1430
V
R
A
I
I
R
H
S
D
L
V
T
K
E
A
Site 120
T1434
I
R
H
S
D
L
V
T
K
E
A
S
F
E
Y
Site 121
S1438
D
L
V
T
K
E
A
S
F
E
Y
L
Q
N
E
Site 122
Y1441
T
K
E
A
S
F
E
Y
L
Q
N
E
G
E
R
Site 123
S1486
P
T
V
I
M
D
P
S
K
I
E
E
S
V
R
Site 124
S1491
D
P
S
K
I
E
E
S
V
R
S
M
V
M
R
Site 125
S1494
K
I
E
E
S
V
R
S
M
V
M
R
Y
G
S
Site 126
Y1499
V
R
S
M
V
M
R
Y
G
S
R
L
W
K
L
Site 127
S1501
S
M
V
M
R
Y
G
S
R
L
W
K
L
R
V
Site 128
Y1539
L
T
N
E
S
G
Y
Y
L
D
I
S
L
Y
K
Site 129
S1543
S
G
Y
Y
L
D
I
S
L
Y
K
E
V
T
D
Site 130
Y1545
Y
Y
L
D
I
S
L
Y
K
E
V
T
D
S
R
Site 131
T1549
I
S
L
Y
K
E
V
T
D
S
R
T
A
Q
I
Site 132
S1551
L
Y
K
E
V
T
D
S
R
T
A
Q
I
M
F
Site 133
Y1561
A
Q
I
M
F
Q
A
Y
G
D
K
Q
G
P
L
Site 134
S1585
V
T
K
D
L
L
Q
S
K
R
F
Q
A
Q
S
Site 135
S1592
S
K
R
F
Q
A
Q
S
L
G
T
T
Y
I
Y
Site 136
Y1597
A
Q
S
L
G
T
T
Y
I
Y
D
I
P
E
M
Site 137
Y1599
S
L
G
T
T
Y
I
Y
D
I
P
E
M
F
R
Site 138
S1608
I
P
E
M
F
R
Q
S
L
I
K
L
W
E
S
Site 139
S1617
I
K
L
W
E
S
M
S
T
Q
A
F
L
P
S
Site 140
T1618
K
L
W
E
S
M
S
T
Q
A
F
L
P
S
P
Site 141
S1624
S
T
Q
A
F
L
P
S
P
P
L
P
S
D
M
Site 142
S1629
L
P
S
P
P
L
P
S
D
M
L
T
Y
T
E
Site 143
S1668
A
W
K
M
T
F
K
S
P
E
Y
P
E
G
R
Site 144
Y1671
M
T
F
K
S
P
E
Y
P
E
G
R
D
I
I
Site 145
S1690
D
I
T
Y
R
I
G
S
F
G
P
Q
E
D
L
Site 146
Y1715
A
E
G
I
P
R
I
Y
V
S
A
N
S
G
A
Site 147
Y1745
W
V
D
P
E
D
P
Y
K
G
Y
R
Y
L
Y
Site 148
Y1750
D
P
Y
K
G
Y
R
Y
L
Y
L
T
P
Q
D
Site 149
Y1752
Y
K
G
Y
R
Y
L
Y
L
T
P
Q
D
Y
K
Site 150
T1754
G
Y
R
Y
L
Y
L
T
P
Q
D
Y
K
R
V
Site 151
Y1758
L
Y
L
T
P
Q
D
Y
K
R
V
S
A
L
N
Site 152
S1762
P
Q
D
Y
K
R
V
S
A
L
N
S
V
H
C
Site 153
S1766
K
R
V
S
A
L
N
S
V
H
C
E
H
V
E
Site 154
S1800
G
P
E
N
L
R
G
S
G
M
I
A
G
E
S
Site 155
T1838
L
V
R
L
G
Q
R
T
I
Q
V
E
N
S
H
Site 156
S1844
R
T
I
Q
V
E
N
S
H
L
I
L
T
G
A
Site 157
T1849
E
N
S
H
L
I
L
T
G
A
G
A
L
N
K
Site 158
Y1863
K
V
L
G
R
E
V
Y
T
S
N
N
Q
L
G
Site 159
S1865
L
G
R
E
V
Y
T
S
N
N
Q
L
G
G
I
Site 160
Y1901
T
V
L
H
W
L
S
Y
M
P
K
S
V
H
S
Site 161
S1905
W
L
S
Y
M
P
K
S
V
H
S
S
V
P
L
Site 162
S1908
Y
M
P
K
S
V
H
S
S
V
P
L
L
N
S
Site 163
S1909
M
P
K
S
V
H
S
S
V
P
L
L
N
S
K
Site 164
S1915
S
S
V
P
L
L
N
S
K
D
P
I
D
R
I
Site 165
T1928
R
I
I
E
F
V
P
T
K
T
P
Y
D
P
R
Site 166
T1930
I
E
F
V
P
T
K
T
P
Y
D
P
R
W
M
Site 167
Y1932
F
V
P
T
K
T
P
Y
D
P
R
W
M
L
A
Site 168
S1959
S
G
F
F
D
Y
G
S
F
S
E
I
M
Q
P
Site 169
S1996
E
T
R
T
V
E
L
S
I
P
A
D
P
A
N
Site 170
S2006
A
D
P
A
N
L
D
S
E
A
K
I
I
Q
Q
Site 171
T2026
F
P
D
S
A
F
K
T
Y
Q
A
I
K
D
F
Site 172
Y2057
S
G
G
M
K
D
M
Y
D
Q
V
L
K
F
G
Site 173
S2092
Q
A
E
L
R
G
G
S
W
V
V
I
D
S
S
Site 174
S2099
S
W
V
V
I
D
S
S
I
N
P
R
H
M
E
Site 175
Y2108
N
P
R
H
M
E
M
Y
A
D
R
E
S
R
G
Site 176
S2113
E
M
Y
A
D
R
E
S
R
G
S
V
L
E
P
Site 177
S2116
A
D
R
E
S
R
G
S
V
L
E
P
E
G
T
Site 178
T2123
S
V
L
E
P
E
G
T
V
E
I
K
F
R
R
Site 179
T2136
R
R
K
D
L
V
K
T
M
R
R
V
D
P
V
Site 180
Y2144
M
R
R
V
D
P
V
Y
I
H
L
A
E
R
L
Site 181
T2153
H
L
A
E
R
L
G
T
P
E
L
S
T
A
E
Site 182
S2157
R
L
G
T
P
E
L
S
T
A
E
R
K
E
L
Site 183
T2192
Q
F
A
D
L
H
D
T
P
G
R
M
Q
E
K
Site 184
Y2216
K
T
S
R
T
F
F
Y
W
R
L
R
R
L
L
Site 185
Y2262
V
E
G
T
V
K
A
Y
V
W
D
N
N
K
D
Site 186
T2279
E
W
L
E
K
Q
L
T
E
E
D
G
V
H
S
Site 187
S2286
T
E
E
D
G
V
H
S
V
I
E
E
N
I
K
Site 188
Y2299
I
K
C
I
S
R
D
Y
V
L
K
Q
I
R
S
Site 189
S2306
Y
V
L
K
Q
I
R
S
L
V
Q
A
N
P
E
Site 190
S2327
I
H
M
T
Q
H
I
S
P
T
Q
R
A
E
V
Site 191
T2329
M
T
Q
H
I
S
P
T
Q
R
A
E
V
I
R
Site 192
S2339
A
E
V
I
R
I
L
S
T
M
D
S
P
S
T
Site 193
T2340
E
V
I
R
I
L
S
T
M
D
S
P
S
T
_
Site 194
S2343
R
I
L
S
T
M
D
S
P
S
T
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation