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Updated November 2019
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Protein Info
Short Name:
NFAT4
Full Name:
Nuclear factor of activated T-cells, cytoplasmic 3
Alias:
NFAC3; NF-AT4; NFATC3; NF-ATc3; NFATx; NFC3; Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4
Type:
Transcription protein
Mass (Da):
115594
Number AA:
1075
UniProt ID:
Q12968
International Prot ID:
IPI00030369
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
P
A
P
P
P
P
G
S
R
P
A
D
L
E
P
Site 2
Y45
P
D
D
C
A
S
I
Y
I
F
N
V
D
P
P
Site 3
S54
F
N
V
D
P
P
P
S
T
L
T
T
P
L
C
Site 4
T58
P
P
P
S
T
L
T
T
P
L
C
L
P
H
H
Site 5
S69
L
P
H
H
G
L
P
S
H
S
S
V
L
S
P
Site 6
S71
H
H
G
L
P
S
H
S
S
V
L
S
P
S
F
Site 7
S72
H
G
L
P
S
H
S
S
V
L
S
P
S
F
Q
Site 8
S75
P
S
H
S
S
V
L
S
P
S
F
Q
L
Q
S
Site 9
S77
H
S
S
V
L
S
P
S
F
Q
L
Q
S
H
K
Site 10
Y86
Q
L
Q
S
H
K
N
Y
E
G
T
C
E
I
P
Site 11
T89
S
H
K
N
Y
E
G
T
C
E
I
P
E
S
K
Site 12
S95
G
T
C
E
I
P
E
S
K
Y
S
P
L
G
G
Site 13
Y97
C
E
I
P
E
S
K
Y
S
P
L
G
G
P
K
Site 14
S98
E
I
P
E
S
K
Y
S
P
L
G
G
P
K
P
Site 15
S110
P
K
P
F
E
C
P
S
I
Q
I
T
S
I
S
Site 16
T114
E
C
P
S
I
Q
I
T
S
I
S
P
N
C
H
Site 17
S117
S
I
Q
I
T
S
I
S
P
N
C
H
Q
E
L
Site 18
S145
R
E
F
L
E
R
P
S
R
D
H
L
Y
L
P
Site 19
Y150
R
P
S
R
D
H
L
Y
L
P
L
E
P
S
Y
Site 20
S156
L
Y
L
P
L
E
P
S
Y
R
E
S
S
L
S
Site 21
Y157
Y
L
P
L
E
P
S
Y
R
E
S
S
L
S
P
Site 22
S160
L
E
P
S
Y
R
E
S
S
L
S
P
S
P
A
Site 23
S161
E
P
S
Y
R
E
S
S
L
S
P
S
P
A
S
Site 24
S163
S
Y
R
E
S
S
L
S
P
S
P
A
S
S
I
Site 25
S165
R
E
S
S
L
S
P
S
P
A
S
S
I
S
S
Site 26
S168
S
L
S
P
S
P
A
S
S
I
S
S
R
S
W
Site 27
S169
L
S
P
S
P
A
S
S
I
S
S
R
S
W
F
Site 28
S171
P
S
P
A
S
S
I
S
S
R
S
W
F
S
D
Site 29
S172
S
P
A
S
S
I
S
S
R
S
W
F
S
D
A
Site 30
S174
A
S
S
I
S
S
R
S
W
F
S
D
A
S
S
Site 31
S177
I
S
S
R
S
W
F
S
D
A
S
S
C
E
S
Site 32
S180
R
S
W
F
S
D
A
S
S
C
E
S
L
S
H
Site 33
S181
S
W
F
S
D
A
S
S
C
E
S
L
S
H
I
Site 34
S184
S
D
A
S
S
C
E
S
L
S
H
I
Y
D
D
Site 35
S186
A
S
S
C
E
S
L
S
H
I
Y
D
D
V
D
Site 36
S194
H
I
Y
D
D
V
D
S
E
L
N
E
A
A
A
Site 37
T204
N
E
A
A
A
R
F
T
L
G
S
P
L
T
S
Site 38
S207
A
A
R
F
T
L
G
S
P
L
T
S
P
G
G
Site 39
T210
F
T
L
G
S
P
L
T
S
P
G
G
S
P
G
Site 40
S211
T
L
G
S
P
L
T
S
P
G
G
S
P
G
G
Site 41
S215
P
L
T
S
P
G
G
S
P
G
G
C
P
G
E
Site 42
S234
Q
Q
Y
G
L
G
H
S
L
S
P
R
Q
S
P
Site 43
S236
Y
G
L
G
H
S
L
S
P
R
Q
S
P
C
H
Site 44
S240
H
S
L
S
P
R
Q
S
P
C
H
S
P
R
S
Site 45
S244
P
R
Q
S
P
C
H
S
P
R
S
S
V
T
D
Site 46
S247
S
P
C
H
S
P
R
S
S
V
T
D
E
N
W
Site 47
S248
P
C
H
S
P
R
S
S
V
T
D
E
N
W
L
Site 48
S256
V
T
D
E
N
W
L
S
P
R
P
A
S
G
P
Site 49
S261
W
L
S
P
R
P
A
S
G
P
S
S
R
P
T
Site 50
S264
P
R
P
A
S
G
P
S
S
R
P
T
S
P
C
Site 51
S265
R
P
A
S
G
P
S
S
R
P
T
S
P
C
G
Site 52
T268
S
G
P
S
S
R
P
T
S
P
C
G
K
R
R
Site 53
S269
G
P
S
S
R
P
T
S
P
C
G
K
R
R
H
Site 54
S277
P
C
G
K
R
R
H
S
S
A
E
V
C
Y
A
Site 55
S278
C
G
K
R
R
H
S
S
A
E
V
C
Y
A
G
Site 56
S286
A
E
V
C
Y
A
G
S
L
S
P
H
H
S
P
Site 57
S288
V
C
Y
A
G
S
L
S
P
H
H
S
P
V
P
Site 58
S292
G
S
L
S
P
H
H
S
P
V
P
S
P
G
H
Site 59
S296
P
H
H
S
P
V
P
S
P
G
H
S
P
R
G
Site 60
S300
P
V
P
S
P
G
H
S
P
R
G
S
V
T
E
Site 61
S304
P
G
H
S
P
R
G
S
V
T
E
D
T
W
L
Site 62
T309
R
G
S
V
T
E
D
T
W
L
N
A
S
V
H
Site 63
S314
E
D
T
W
L
N
A
S
V
H
G
G
S
G
L
Site 64
T340
E
T
D
I
P
L
K
T
R
K
T
S
E
D
Q
Site 65
T343
I
P
L
K
T
R
K
T
S
E
D
Q
A
A
I
Site 66
S344
P
L
K
T
R
K
T
S
E
D
Q
A
A
I
L
Site 67
S359
P
G
K
L
E
L
C
S
D
D
Q
G
S
L
S
Site 68
S364
L
C
S
D
D
Q
G
S
L
S
P
A
R
E
T
Site 69
S366
S
D
D
Q
G
S
L
S
P
A
R
E
T
S
I
Site 70
T371
S
L
S
P
A
R
E
T
S
I
D
D
G
L
G
Site 71
S372
L
S
P
A
R
E
T
S
I
D
D
G
L
G
S
Site 72
S379
S
I
D
D
G
L
G
S
Q
Y
P
L
K
K
D
Site 73
Y381
D
D
G
L
G
S
Q
Y
P
L
K
K
D
S
C
Site 74
S387
Q
Y
P
L
K
K
D
S
C
G
D
Q
F
L
S
Site 75
S394
S
C
G
D
Q
F
L
S
V
P
S
P
F
T
W
Site 76
S397
D
Q
F
L
S
V
P
S
P
F
T
W
S
K
P
Site 77
T400
L
S
V
P
S
P
F
T
W
S
K
P
K
P
G
Site 78
S402
V
P
S
P
F
T
W
S
K
P
K
P
G
H
T
Site 79
T409
S
K
P
K
P
G
H
T
P
I
F
R
T
S
S
Site 80
S415
H
T
P
I
F
R
T
S
S
L
P
P
L
D
W
Site 81
S416
T
P
I
F
R
T
S
S
L
P
P
L
D
W
P
Site 82
T441
K
I
E
V
Q
P
K
T
H
H
R
A
H
Y
E
Site 83
Y447
K
T
H
H
R
A
H
Y
E
T
E
G
S
R
G
Site 84
T449
H
H
R
A
H
Y
E
T
E
G
S
R
G
A
V
Site 85
S459
S
R
G
A
V
K
A
S
T
G
G
H
P
V
V
Site 86
Y489
I
G
T
A
D
D
R
Y
L
R
P
H
A
F
Y
Site 87
Y496
Y
L
R
P
H
A
F
Y
Q
V
H
R
I
T
G
Site 88
T502
F
Y
Q
V
H
R
I
T
G
K
T
V
A
T
A
Site 89
T505
V
H
R
I
T
G
K
T
V
A
T
A
S
Q
E
Site 90
S546
G
I
L
K
L
R
N
S
D
I
E
L
R
K
G
Site 91
T562
T
D
I
G
R
K
N
T
R
V
R
L
V
F
R
Site 92
S576
R
V
H
I
P
Q
P
S
G
K
V
L
S
L
Q
Site 93
S592
A
S
I
P
V
E
C
S
Q
R
S
A
Q
E
L
Site 94
S595
P
V
E
C
S
Q
R
S
A
Q
E
L
P
H
I
Site 95
Y605
E
L
P
H
I
E
K
Y
S
I
N
S
C
S
V
Site 96
S609
I
E
K
Y
S
I
N
S
C
S
V
N
G
G
H
Site 97
T621
G
G
H
E
M
V
V
T
G
S
N
F
L
P
E
Site 98
S629
G
S
N
F
L
P
E
S
K
I
I
F
L
E
K
Site 99
Y681
A
A
V
Q
V
H
F
Y
L
C
N
G
K
R
K
Site 100
S690
C
N
G
K
R
K
K
S
Q
S
Q
R
F
T
Y
Site 101
S692
G
K
R
K
K
S
Q
S
Q
R
F
T
Y
T
P
Site 102
T696
K
S
Q
S
Q
R
F
T
Y
T
P
V
L
M
K
Site 103
Y697
S
Q
S
Q
R
F
T
Y
T
P
V
L
M
K
Q
Site 104
T698
Q
S
Q
R
F
T
Y
T
P
V
L
M
K
Q
E
Site 105
S713
H
R
E
E
I
D
L
S
S
V
P
S
L
P
V
Site 106
S714
R
E
E
I
D
L
S
S
V
P
S
L
P
V
P
Site 107
T726
P
V
P
H
P
A
Q
T
Q
R
P
S
S
D
S
Site 108
S730
P
A
Q
T
Q
R
P
S
S
D
S
G
C
S
H
Site 109
S731
A
Q
T
Q
R
P
S
S
D
S
G
C
S
H
D
Site 110
S733
T
Q
R
P
S
S
D
S
G
C
S
H
D
S
V
Site 111
S736
P
S
S
D
S
G
C
S
H
D
S
V
L
S
G
Site 112
S739
D
S
G
C
S
H
D
S
V
L
S
G
Q
R
S
Site 113
S742
C
S
H
D
S
V
L
S
G
Q
R
S
L
I
C
Site 114
S750
G
Q
R
S
L
I
C
S
I
P
Q
T
Y
A
S
Site 115
S757
S
I
P
Q
T
Y
A
S
M
V
T
S
S
H
L
Site 116
S761
T
Y
A
S
M
V
T
S
S
H
L
P
Q
L
Q
Site 117
S773
Q
L
Q
C
R
D
E
S
V
S
K
E
Q
H
M
Site 118
S775
Q
C
R
D
E
S
V
S
K
E
Q
H
M
I
P
Site 119
S783
K
E
Q
H
M
I
P
S
P
I
V
H
Q
P
F
Site 120
T793
V
H
Q
P
F
Q
V
T
P
T
P
P
V
G
S
Site 121
T795
Q
P
F
Q
V
T
P
T
P
P
V
G
S
S
Y
Site 122
S801
P
T
P
P
V
G
S
S
Y
Q
P
M
Q
T
N
Site 123
T807
S
S
Y
Q
P
M
Q
T
N
V
V
Y
N
G
P
Site 124
Y811
P
M
Q
T
N
V
V
Y
N
G
P
T
C
L
P
Site 125
S850
N
L
G
C
Q
P
L
S
S
I
P
F
H
S
S
Site 126
S851
L
G
C
Q
P
L
S
S
I
P
F
H
S
S
N
Site 127
S856
L
S
S
I
P
F
H
S
S
N
S
G
S
T
G
Site 128
S857
S
S
I
P
F
H
S
S
N
S
G
S
T
G
H
Site 129
S859
I
P
F
H
S
S
N
S
G
S
T
G
H
L
L
Site 130
S861
F
H
S
S
N
S
G
S
T
G
H
L
L
A
H
Site 131
T869
T
G
H
L
L
A
H
T
P
H
S
V
H
T
L
Site 132
Y884
P
H
L
Q
S
M
G
Y
H
C
S
N
T
G
Q
Site 133
S887
Q
S
M
G
Y
H
C
S
N
T
G
Q
R
S
L
Site 134
T889
M
G
Y
H
C
S
N
T
G
Q
R
S
L
S
S
Site 135
S893
C
S
N
T
G
Q
R
S
L
S
S
P
V
A
D
Site 136
S895
N
T
G
Q
R
S
L
S
S
P
V
A
D
Q
I
Site 137
S896
T
G
Q
R
S
L
S
S
P
V
A
D
Q
I
T
Site 138
T903
S
P
V
A
D
Q
I
T
G
Q
P
S
S
Q
L
Site 139
S908
Q
I
T
G
Q
P
S
S
Q
L
Q
P
I
T
Y
Site 140
T914
S
S
Q
L
Q
P
I
T
Y
G
P
S
H
S
G
Site 141
Y915
S
Q
L
Q
P
I
T
Y
G
P
S
H
S
G
S
Site 142
S918
Q
P
I
T
Y
G
P
S
H
S
G
S
A
T
T
Site 143
S920
I
T
Y
G
P
S
H
S
G
S
A
T
T
A
S
Site 144
S922
Y
G
P
S
H
S
G
S
A
T
T
A
S
P
A
Site 145
T924
P
S
H
S
G
S
A
T
T
A
S
P
A
A
S
Site 146
T925
S
H
S
G
S
A
T
T
A
S
P
A
A
S
H
Site 147
S927
S
G
S
A
T
T
A
S
P
A
A
S
H
P
L
Site 148
S931
T
T
A
S
P
A
A
S
H
P
L
A
S
S
P
Site 149
S936
A
A
S
H
P
L
A
S
S
P
L
S
G
P
P
Site 150
S937
A
S
H
P
L
A
S
S
P
L
S
G
P
P
S
Site 151
S940
P
L
A
S
S
P
L
S
G
P
P
S
P
Q
L
Site 152
S944
S
P
L
S
G
P
P
S
P
Q
L
Q
P
M
P
Site 153
Y952
P
Q
L
Q
P
M
P
Y
Q
S
P
S
S
G
T
Site 154
S954
L
Q
P
M
P
Y
Q
S
P
S
S
G
T
A
S
Site 155
S956
P
M
P
Y
Q
S
P
S
S
G
T
A
S
S
P
Site 156
S957
M
P
Y
Q
S
P
S
S
G
T
A
S
S
P
S
Site 157
S961
S
P
S
S
G
T
A
S
S
P
S
P
A
T
R
Site 158
S962
P
S
S
G
T
A
S
S
P
S
P
A
T
R
M
Site 159
S964
S
G
T
A
S
S
P
S
P
A
T
R
M
H
S
Site 160
T967
A
S
S
P
S
P
A
T
R
M
H
S
G
Q
H
Site 161
S971
S
P
A
T
R
M
H
S
G
Q
H
S
T
Q
A
Site 162
S975
R
M
H
S
G
Q
H
S
T
Q
A
Q
S
T
G
Site 163
T976
M
H
S
G
Q
H
S
T
Q
A
Q
S
T
G
Q
Site 164
S1002
H
S
L
C
D
P
A
S
F
P
P
D
G
A
T
Site 165
T1009
S
F
P
P
D
G
A
T
V
S
I
K
P
E
P
Site 166
S1011
P
P
D
G
A
T
V
S
I
K
P
E
P
E
D
Site 167
S1045
E
I
I
G
R
D
M
S
Q
I
S
V
S
Q
G
Site 168
S1048
G
R
D
M
S
Q
I
S
V
S
Q
G
A
G
V
Site 169
S1050
D
M
S
Q
I
S
V
S
Q
G
A
G
V
S
R
Site 170
S1063
S
R
Q
A
P
L
P
S
P
E
S
L
D
L
G
Site 171
S1066
A
P
L
P
S
P
E
S
L
D
L
G
R
S
D
Site 172
S1072
E
S
L
D
L
G
R
S
D
G
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation