KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GRIN2A
Full Name:
Glutamate [NMDA] receptor subunit epsilon-1
Alias:
Glutamate [NMDA] receptor subunit epsilon 1 precursor; Glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDAR2A; NMDAR2AGlutamate [NMDA] receptor subunit epsilon 1; NMDE1; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subtype 2A; NR2A
Type:
Channel, ligand-gated
Mass (Da):
165283
Number AA:
1464
UniProt ID:
Q12879
International Prot ID:
IPI00029768
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0017146
GO:0030054
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0004972
GO:0005509
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0045471
Phosida
TranscriptoNet
STRING
Kinexus Products
Glutamate receptor ionotropic, NMDA 2A pan-specific antibody AB-NN297-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN297-1#Glutamate receptor ionotropic, NMDA 2A pan-specific antibody AB-NN297-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN297-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
V
W
R
G
P
A
P
S
A
A
A
E
K
G
P
Site 2
T47
L
G
H
S
H
D
V
T
E
R
E
L
R
T
L
Site 3
T104
G
L
V
F
G
D
D
T
D
Q
E
A
V
A
Q
Site 4
S142
M
A
D
K
D
P
T
S
T
F
F
Q
F
G
A
Site 5
T143
A
D
K
D
P
T
S
T
F
F
Q
F
G
A
S
Site 6
S185
P
G
Y
R
E
F
I
S
F
V
K
T
T
V
D
Site 7
S209
N
V
I
T
L
D
T
S
F
E
D
A
K
T
Q
Site 8
T215
T
S
F
E
D
A
K
T
Q
V
Q
L
K
K
I
Site 9
S278
E
F
P
S
G
L
I
S
V
S
Y
D
D
W
D
Site 10
S280
P
S
G
L
I
S
V
S
Y
D
D
W
D
Y
S
Site 11
Y281
S
G
L
I
S
V
S
Y
D
D
W
D
Y
S
L
Site 12
Y286
V
S
Y
D
D
W
D
Y
S
L
E
A
R
V
R
Site 13
S287
S
Y
D
D
W
D
Y
S
L
E
A
R
V
R
D
Site 14
Y312
S
M
L
E
K
F
S
Y
I
P
E
A
K
A
S
Site 15
T333
R
P
E
V
P
M
H
T
L
H
P
F
M
V
N
Site 16
S349
T
W
D
G
K
D
L
S
F
T
E
E
G
Y
Q
Site 17
T382
V
G
K
W
E
N
H
T
L
S
L
R
H
A
V
Site 18
Y393
R
H
A
V
W
P
R
Y
K
S
F
S
D
C
E
Site 19
S395
A
V
W
P
R
Y
K
S
F
S
D
C
E
P
D
Site 20
S397
W
P
R
Y
K
S
F
S
D
C
E
P
D
D
N
Site 21
S407
E
P
D
D
N
H
L
S
I
V
T
L
E
E
A
Site 22
T426
V
E
D
I
D
P
L
T
E
T
C
V
R
N
T
Site 23
T428
D
I
D
P
L
T
E
T
C
V
R
N
T
V
P
Site 24
T433
T
E
T
C
V
R
N
T
V
P
C
R
K
F
V
Site 25
T470
I
L
K
K
L
S
R
T
V
K
F
T
Y
D
L
Site 26
Y478
V
K
F
T
Y
D
L
Y
L
V
T
N
G
K
H
Site 27
S540
I
S
V
M
V
S
R
S
N
G
T
V
S
P
S
Site 28
S545
S
R
S
N
G
T
V
S
P
S
A
F
L
E
P
Site 29
S547
S
N
G
T
V
S
P
S
A
F
L
E
P
F
S
Site 30
Y584
E
Y
F
S
P
V
G
Y
N
R
N
L
A
K
G
Site 31
S598
G
K
A
P
H
G
P
S
F
T
I
G
K
A
I
Site 32
S666
V
D
Q
V
T
G
L
S
D
K
K
F
Q
R
P
Site 33
Y676
K
F
Q
R
P
H
D
Y
S
P
P
F
R
F
G
Site 34
S677
F
Q
R
P
H
D
Y
S
P
P
F
R
F
G
T
Site 35
T684
S
P
P
F
R
F
G
T
V
P
N
G
S
T
E
Site 36
S689
F
G
T
V
P
N
G
S
T
E
R
N
I
R
N
Site 37
Y730
G
K
L
D
A
F
I
Y
D
A
A
V
L
N
Y
Site 38
Y737
Y
D
A
A
V
L
N
Y
K
A
G
R
D
E
G
Site 39
S769
G
I
A
L
Q
K
G
S
P
W
K
R
Q
I
D
Site 40
S810
E
K
N
E
V
M
S
S
Q
L
D
I
D
N
M
Site 41
S862
D
R
P
G
L
L
F
S
I
S
R
G
I
Y
S
Site 42
S882
H
I
E
E
K
K
K
S
P
D
F
N
L
T
G
Site 43
T888
K
S
P
D
F
N
L
T
G
S
Q
S
N
M
L
Site 44
S890
P
D
F
N
L
T
G
S
Q
S
N
M
L
K
L
Site 45
S892
F
N
L
T
G
S
Q
S
N
M
L
K
L
L
R
Site 46
S900
N
M
L
K
L
L
R
S
A
K
N
I
S
S
M
Site 47
S905
L
R
S
A
K
N
I
S
S
M
S
N
M
N
S
Site 48
S906
R
S
A
K
N
I
S
S
M
S
N
M
N
S
S
Site 49
S908
A
K
N
I
S
S
M
S
N
M
N
S
S
R
M
Site 50
S912
S
S
M
S
N
M
N
S
S
R
M
D
S
P
K
Site 51
S913
S
M
S
N
M
N
S
S
R
M
D
S
P
K
R
Site 52
S917
M
N
S
S
R
M
D
S
P
K
R
A
A
D
F
Site 53
S929
A
D
F
I
Q
R
G
S
L
I
M
D
M
V
S
Site 54
Y943
S
D
K
G
N
L
M
Y
S
D
N
R
S
F
Q
Site 55
S944
D
K
G
N
L
M
Y
S
D
N
R
S
F
Q
G
Site 56
S948
L
M
Y
S
D
N
R
S
F
Q
G
K
E
S
I
Site 57
T965
D
N
M
N
E
L
Q
T
F
V
A
N
R
Q
K
Site 58
Y978
Q
K
D
N
L
N
N
Y
V
F
Q
G
Q
H
P
Site 59
T987
F
Q
G
Q
H
P
L
T
L
N
E
S
N
P
N
Site 60
S991
H
P
L
T
L
N
E
S
N
P
N
T
V
E
V
Site 61
T995
L
N
E
S
N
P
N
T
V
E
V
A
V
S
T
Site 62
S1001
N
T
V
E
V
A
V
S
T
E
S
K
A
N
S
Site 63
S1004
E
V
A
V
S
T
E
S
K
A
N
S
R
P
R
Site 64
S1008
S
T
E
S
K
A
N
S
R
P
R
Q
L
W
K
Site 65
S1017
P
R
Q
L
W
K
K
S
V
D
S
I
R
Q
D
Site 66
S1020
L
W
K
K
S
V
D
S
I
R
Q
D
S
L
S
Site 67
S1025
V
D
S
I
R
Q
D
S
L
S
Q
N
P
V
S
Site 68
S1027
S
I
R
Q
D
S
L
S
Q
N
P
V
S
Q
R
Site 69
S1032
S
L
S
Q
N
P
V
S
Q
R
D
E
A
T
A
Site 70
T1038
V
S
Q
R
D
E
A
T
A
E
N
R
T
H
S
Site 71
S1045
T
A
E
N
R
T
H
S
L
K
S
P
R
Y
L
Site 72
S1048
N
R
T
H
S
L
K
S
P
R
Y
L
P
E
E
Site 73
Y1051
H
S
L
K
S
P
R
Y
L
P
E
E
M
A
H
Site 74
S1059
L
P
E
E
M
A
H
S
D
I
S
E
T
S
N
Site 75
S1062
E
M
A
H
S
D
I
S
E
T
S
N
R
A
T
Site 76
S1065
H
S
D
I
S
E
T
S
N
R
A
T
C
H
R
Site 77
T1069
S
E
T
S
N
R
A
T
C
H
R
E
P
D
N
Site 78
T1082
D
N
S
K
N
H
K
T
K
D
N
F
K
R
S
Site 79
S1089
T
K
D
N
F
K
R
S
V
A
S
K
Y
P
K
Site 80
Y1094
K
R
S
V
A
S
K
Y
P
K
D
C
S
E
V
Site 81
S1099
S
K
Y
P
K
D
C
S
E
V
E
R
T
Y
L
Site 82
T1104
D
C
S
E
V
E
R
T
Y
L
K
T
K
S
S
Site 83
Y1105
C
S
E
V
E
R
T
Y
L
K
T
K
S
S
S
Site 84
T1108
V
E
R
T
Y
L
K
T
K
S
S
S
P
R
D
Site 85
S1110
R
T
Y
L
K
T
K
S
S
S
P
R
D
K
I
Site 86
S1111
T
Y
L
K
T
K
S
S
S
P
R
D
K
I
Y
Site 87
S1112
Y
L
K
T
K
S
S
S
P
R
D
K
I
Y
T
Site 88
Y1118
S
S
P
R
D
K
I
Y
T
I
D
G
E
K
E
Site 89
T1119
S
P
R
D
K
I
Y
T
I
D
G
E
K
E
P
Site 90
Y1151
N
V
D
F
P
D
P
Y
Q
D
P
S
E
N
F
Site 91
S1155
P
D
P
Y
Q
D
P
S
E
N
F
R
K
G
D
Site 92
T1164
N
F
R
K
G
D
S
T
L
P
M
N
R
N
P
Site 93
S1179
L
H
N
E
E
G
L
S
N
N
D
Q
Y
K
L
Site 94
Y1184
G
L
S
N
N
D
Q
Y
K
L
Y
S
K
H
F
Site 95
Y1187
N
N
D
Q
Y
K
L
Y
S
K
H
F
T
L
K
Site 96
T1192
K
L
Y
S
K
H
F
T
L
K
D
K
G
S
P
Site 97
S1198
F
T
L
K
D
K
G
S
P
H
S
E
T
S
E
Site 98
S1201
K
D
K
G
S
P
H
S
E
T
S
E
R
Y
R
Site 99
S1204
G
S
P
H
S
E
T
S
E
R
Y
R
Q
N
S
Site 100
Y1207
H
S
E
T
S
E
R
Y
R
Q
N
S
T
H
C
Site 101
S1211
S
E
R
Y
R
Q
N
S
T
H
C
R
S
C
L
Site 102
T1212
E
R
Y
R
Q
N
S
T
H
C
R
S
C
L
S
Site 103
Y1224
C
L
S
N
M
P
T
Y
S
G
H
F
T
M
R
Site 104
S1225
L
S
N
M
P
T
Y
S
G
H
F
T
M
R
S
Site 105
T1229
P
T
Y
S
G
H
F
T
M
R
S
P
F
K
C
Site 106
S1232
S
G
H
F
T
M
R
S
P
F
K
C
D
A
C
Site 107
Y1246
C
L
R
M
G
N
L
Y
D
I
D
E
D
Q
M
Site 108
T1257
E
D
Q
M
L
Q
E
T
G
N
P
A
T
G
E
Site 109
Y1267
P
A
T
G
E
Q
V
Y
Q
Q
D
W
A
Q
N
Site 110
S1287
Q
K
N
K
L
R
I
S
R
Q
H
S
Y
D
N
Site 111
S1291
L
R
I
S
R
Q
H
S
Y
D
N
I
V
D
K
Site 112
Y1292
R
I
S
R
Q
H
S
Y
D
N
I
V
D
K
P
Site 113
S1305
K
P
R
E
L
D
L
S
R
P
S
R
S
I
S
Site 114
S1308
E
L
D
L
S
R
P
S
R
S
I
S
L
K
D
Site 115
S1310
D
L
S
R
P
S
R
S
I
S
L
K
D
R
E
Site 116
S1312
S
R
P
S
R
S
I
S
L
K
D
R
E
R
L
Site 117
Y1325
R
L
L
E
G
N
F
Y
G
S
L
F
S
V
P
Site 118
S1327
L
E
G
N
F
Y
G
S
L
F
S
V
P
S
S
Site 119
S1330
N
F
Y
G
S
L
F
S
V
P
S
S
K
L
S
Site 120
S1333
G
S
L
F
S
V
P
S
S
K
L
S
G
K
K
Site 121
S1334
S
L
F
S
V
P
S
S
K
L
S
G
K
K
S
Site 122
S1337
S
V
P
S
S
K
L
S
G
K
K
S
S
L
F
Site 123
S1341
S
K
L
S
G
K
K
S
S
L
F
P
Q
G
L
Site 124
S1342
K
L
S
G
K
K
S
S
L
F
P
Q
G
L
E
Site 125
S1351
F
P
Q
G
L
E
D
S
K
R
S
K
S
L
L
Site 126
S1356
E
D
S
K
R
S
K
S
L
L
P
D
H
T
S
Site 127
T1362
K
S
L
L
P
D
H
T
S
D
N
P
F
L
H
Site 128
S1363
S
L
L
P
D
H
T
S
D
N
P
F
L
H
S
Site 129
S1370
S
D
N
P
F
L
H
S
H
R
D
D
Q
R
L
Site 130
S1384
L
V
I
G
R
C
P
S
D
P
Y
K
H
S
L
Site 131
Y1387
G
R
C
P
S
D
P
Y
K
H
S
L
P
S
Q
Site 132
S1390
P
S
D
P
Y
K
H
S
L
P
S
Q
A
V
N
Site 133
S1393
P
Y
K
H
S
L
P
S
Q
A
V
N
D
S
Y
Site 134
S1399
P
S
Q
A
V
N
D
S
Y
L
R
S
S
L
R
Site 135
Y1400
S
Q
A
V
N
D
S
Y
L
R
S
S
L
R
S
Site 136
S1403
V
N
D
S
Y
L
R
S
S
L
R
S
T
A
S
Site 137
S1404
N
D
S
Y
L
R
S
S
L
R
S
T
A
S
Y
Site 138
S1407
Y
L
R
S
S
L
R
S
T
A
S
Y
C
S
R
Site 139
T1408
L
R
S
S
L
R
S
T
A
S
Y
C
S
R
D
Site 140
S1410
S
S
L
R
S
T
A
S
Y
C
S
R
D
S
R
Site 141
Y1411
S
L
R
S
T
A
S
Y
C
S
R
D
S
R
G
Site 142
S1413
R
S
T
A
S
Y
C
S
R
D
S
R
G
H
N
Site 143
S1416
A
S
Y
C
S
R
D
S
R
G
H
N
D
V
Y
Site 144
Y1423
S
R
G
H
N
D
V
Y
I
S
E
H
V
M
P
Site 145
Y1439
A
A
N
K
N
N
M
Y
S
T
P
R
V
L
N
Site 146
S1440
A
N
K
N
N
M
Y
S
T
P
R
V
L
N
S
Site 147
T1441
N
K
N
N
M
Y
S
T
P
R
V
L
N
S
C
Site 148
S1447
S
T
P
R
V
L
N
S
C
S
N
R
R
V
Y
Site 149
S1449
P
R
V
L
N
S
C
S
N
R
R
V
Y
K
K
Site 150
Y1454
S
C
S
N
R
R
V
Y
K
K
M
P
S
I
E
Site 151
S1459
R
V
Y
K
K
M
P
S
I
E
S
D
V
_
_
Site 152
S1462
K
K
M
P
S
I
E
S
D
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation