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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SREBP2
Full Name:
Sterol regulatory element-binding protein 2
Alias:
Class D basic helix-loop-helix protein 2;Sterol regulatory element-binding transcription factor 2
Type:
Transcription protein
Mass (Da):
123688
Number AA:
1141
UniProt ID:
Q12772
International Prot ID:
IPI00328793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0032937
GO:0031410
Uniprot
OncoNet
Molecular Function:
GO:0008022
GO:0003702
PhosphoSite+
KinaseNET
Biological Process:
GO:0008203
GO:0045944
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
G
G
L
E
T
M
E
T
L
T
E
L
G
D
E
Site 2
T24
T
E
L
G
D
E
L
T
L
G
D
I
D
E
M
Site 3
S47
G
E
F
P
D
L
F
S
E
Q
L
C
S
S
F
Site 4
S52
L
F
S
E
Q
L
C
S
S
F
P
G
S
G
G
Site 5
S53
F
S
E
Q
L
C
S
S
F
P
G
S
G
G
S
Site 6
S57
L
C
S
S
F
P
G
S
G
G
S
G
S
S
S
Site 7
S60
S
F
P
G
S
G
G
S
G
S
S
S
G
S
S
Site 8
S62
P
G
S
G
G
S
G
S
S
S
G
S
S
G
S
Site 9
S63
G
S
G
G
S
G
S
S
S
G
S
S
G
S
S
Site 10
S64
S
G
G
S
G
S
S
S
G
S
S
G
S
S
S
Site 11
S66
G
S
G
S
S
S
G
S
S
G
S
S
S
S
S
Site 12
S67
S
G
S
S
S
G
S
S
G
S
S
S
S
S
S
Site 13
S69
S
S
S
G
S
S
G
S
S
S
S
S
S
N
G
Site 14
S70
S
S
G
S
S
G
S
S
S
S
S
S
N
G
R
Site 15
S71
S
G
S
S
G
S
S
S
S
S
S
N
G
R
G
Site 16
S72
G
S
S
G
S
S
S
S
S
S
N
G
R
G
S
Site 17
S73
S
S
G
S
S
S
S
S
S
N
G
R
G
S
S
Site 18
S74
S
G
S
S
S
S
S
S
N
G
R
G
S
S
S
Site 19
S79
S
S
S
N
G
R
G
S
S
S
G
A
V
D
P
Site 20
S80
S
S
N
G
R
G
S
S
S
G
A
V
D
P
S
Site 21
S81
S
N
G
R
G
S
S
S
G
A
V
D
P
S
V
Site 22
S87
S
S
G
A
V
D
P
S
V
Q
R
S
F
T
Q
Site 23
S91
V
D
P
S
V
Q
R
S
F
T
Q
V
T
L
P
Site 24
T93
P
S
V
Q
R
S
F
T
Q
V
T
L
P
S
F
Site 25
T96
Q
R
S
F
T
Q
V
T
L
P
S
F
S
P
S
Site 26
S101
Q
V
T
L
P
S
F
S
P
S
A
A
S
P
Q
Site 27
S103
T
L
P
S
F
S
P
S
A
A
S
P
Q
A
P
Site 28
S106
S
F
S
P
S
A
A
S
P
Q
A
P
T
L
Q
Site 29
S117
P
T
L
Q
V
K
V
S
P
T
S
V
P
T
T
Site 30
T119
L
Q
V
K
V
S
P
T
S
V
P
T
T
P
R
Site 31
S120
Q
V
K
V
S
P
T
S
V
P
T
T
P
R
A
Site 32
T124
S
P
T
S
V
P
T
T
P
R
A
T
P
I
L
Site 33
T128
V
P
T
T
P
R
A
T
P
I
L
Q
P
R
P
Site 34
T149
Q
T
Q
L
Q
Q
Q
T
V
M
I
T
P
T
F
Site 35
T153
Q
Q
Q
T
V
M
I
T
P
T
F
S
T
T
P
Site 36
T155
Q
T
V
M
I
T
P
T
F
S
T
T
P
Q
T
Site 37
T159
I
T
P
T
F
S
T
T
P
Q
T
R
I
I
Q
Site 38
Y171
I
I
Q
Q
P
L
I
Y
Q
N
A
A
T
S
F
Site 39
S177
I
Y
Q
N
A
A
T
S
F
Q
V
L
Q
P
Q
Site 40
S191
Q
V
Q
S
L
V
T
S
S
Q
V
Q
P
V
T
Site 41
T213
V
Q
A
Q
R
V
L
T
Q
T
A
N
G
T
L
Site 42
T215
A
Q
R
V
L
T
Q
T
A
N
G
T
L
Q
T
Site 43
T256
K
T
D
S
L
V
L
T
T
L
K
T
D
G
S
Site 44
T333
P
K
E
G
E
R
R
T
T
H
N
I
I
E
K
Site 45
T334
K
E
G
E
R
R
T
T
H
N
I
I
E
K
R
Site 46
S344
I
I
E
K
R
Y
R
S
S
I
N
D
K
I
I
Site 47
S345
I
E
K
R
Y
R
S
S
I
N
D
K
I
I
E
Site 48
S367
T
D
A
K
M
H
K
S
G
V
L
R
K
A
I
Site 49
Y379
K
A
I
D
Y
I
K
Y
L
Q
Q
V
N
H
K
Site 50
S411
L
K
G
I
D
L
G
S
L
V
D
N
E
V
D
Site 51
S432
N
Q
N
V
L
L
M
S
P
P
A
S
D
S
G
Site 52
S436
L
L
M
S
P
P
A
S
D
S
G
S
Q
A
G
Site 53
S438
M
S
P
P
A
S
D
S
G
S
Q
A
G
F
S
Site 54
S440
P
P
A
S
D
S
G
S
Q
A
G
F
S
P
Y
Site 55
S445
S
G
S
Q
A
G
F
S
P
Y
S
I
D
S
E
Site 56
Y447
S
Q
A
G
F
S
P
Y
S
I
D
S
E
P
G
Site 57
S448
Q
A
G
F
S
P
Y
S
I
D
S
E
P
G
S
Site 58
S451
F
S
P
Y
S
I
D
S
E
P
G
S
P
L
L
Site 59
S455
S
I
D
S
E
P
G
S
P
L
L
D
D
A
K
Site 60
S469
K
V
K
D
E
P
D
S
P
P
V
A
L
G
M
Site 61
S515
D
S
D
Q
H
P
H
S
G
S
G
R
S
V
L
Site 62
S517
D
Q
H
P
H
S
G
S
G
R
S
V
L
S
F
Site 63
S520
P
H
S
G
S
G
R
S
V
L
S
F
E
S
G
Site 64
S523
G
S
G
R
S
V
L
S
F
E
S
G
S
G
G
Site 65
S526
R
S
V
L
S
F
E
S
G
S
G
G
W
F
D
Site 66
S568
E
P
V
I
R
P
H
S
R
S
S
V
T
F
W
Site 67
S570
V
I
R
P
H
S
R
S
S
V
T
F
W
R
H
Site 68
S571
I
R
P
H
S
R
S
S
V
T
F
W
R
H
R
Site 69
T573
P
H
S
R
S
S
V
T
F
W
R
H
R
K
Q
Site 70
S627
S
W
N
V
I
R
Y
S
L
Q
K
L
R
L
V
Site 71
T648
V
F
Q
C
R
R
A
T
P
A
T
E
A
G
F
Site 72
T651
C
R
R
A
T
P
A
T
E
A
G
F
E
D
E
Site 73
Y670
A
R
D
A
A
L
A
Y
H
R
L
H
Q
L
H
Site 74
S686
T
G
K
L
P
A
G
S
A
C
S
D
V
H
M
Site 75
S711
A
E
E
K
I
P
P
S
T
L
V
E
I
H
L
Site 76
T712
E
E
K
I
P
P
S
T
L
V
E
I
H
L
T
Site 77
T726
T
A
A
M
G
L
K
T
R
C
G
G
K
L
G
Site 78
S745
Y
F
L
S
R
A
Q
S
L
C
G
P
E
H
S
Site 79
S752
S
L
C
G
P
E
H
S
A
V
P
D
S
L
R
Site 80
S757
E
H
S
A
V
P
D
S
L
R
W
L
C
H
P
Site 81
S774
Q
K
F
F
M
E
R
S
W
S
V
K
S
A
A
Site 82
S776
F
F
M
E
R
S
W
S
V
K
S
A
A
K
E
Site 83
S779
E
R
S
W
S
V
K
S
A
A
K
E
S
L
Y
Site 84
Y786
S
A
A
K
E
S
L
Y
C
A
Q
R
N
P
A
Site 85
S831
A
G
D
Q
E
E
E
S
C
E
F
S
S
A
L
Site 86
S835
E
E
E
S
C
E
F
S
S
A
L
E
Y
L
K
Site 87
Y840
E
F
S
S
A
L
E
Y
L
K
L
L
H
S
F
Site 88
S855
V
D
S
V
G
V
M
S
P
P
L
S
R
S
S
Site 89
S859
G
V
M
S
P
P
L
S
R
S
S
V
L
K
S
Site 90
S861
M
S
P
P
L
S
R
S
S
V
L
K
S
A
L
Site 91
S862
S
P
P
L
S
R
S
S
V
L
K
S
A
L
G
Site 92
S930
A
C
R
A
M
H
A
S
L
P
G
K
A
D
G
Site 93
S941
K
A
D
G
Q
Q
S
S
F
C
H
C
E
R
A
Site 94
S954
R
A
S
G
H
L
W
S
S
L
N
V
S
G
A
Site 95
S955
A
S
G
H
L
W
S
S
L
N
V
S
G
A
T
Site 96
S959
L
W
S
S
L
N
V
S
G
A
T
S
D
P
A
Site 97
S963
L
N
V
S
G
A
T
S
D
P
A
L
N
H
V
Site 98
S994
W
Q
K
Q
A
S
A
S
Q
A
V
G
E
T
Y
Site 99
Y1001
S
Q
A
V
G
E
T
Y
H
A
S
G
A
E
L
Site 100
S1017
G
F
Q
R
D
L
G
S
L
R
R
L
A
H
S
Site 101
S1024
S
L
R
R
L
A
H
S
F
R
P
A
Y
R
K
Site 102
Y1029
A
H
S
F
R
P
A
Y
R
K
V
F
L
H
E
Site 103
S1046
V
R
L
M
A
G
A
S
P
T
R
T
H
Q
L
Site 104
T1050
A
G
A
S
P
T
R
T
H
Q
L
L
E
H
S
Site 105
S1057
T
H
Q
L
L
E
H
S
L
R
R
R
T
T
Q
Site 106
T1062
E
H
S
L
R
R
R
T
T
Q
S
T
K
H
G
Site 107
T1063
H
S
L
R
R
R
T
T
Q
S
T
K
H
G
E
Site 108
S1065
L
R
R
R
T
T
Q
S
T
K
H
G
E
V
D
Site 109
T1066
R
R
R
T
T
Q
S
T
K
H
G
E
V
D
A
Site 110
T1082
P
G
Q
R
E
R
A
T
A
I
L
L
A
C
R
Site 111
S1094
A
C
R
H
L
P
L
S
F
L
S
S
P
G
Q
Site 112
T1112
L
L
A
E
A
A
R
T
L
E
K
V
G
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation