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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NSUN2
Full Name:
tRNA (cytosine-5-)-methyltransferase NSUN2
Alias:
EC 2.1.1.-; EC 2.1.1.29; FLJ20303; MISU; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family, member 2; SAKI; TRM4; TRNA (cytosine-5-)-methyltransferase; TRNA (cytosine-5-)-methyltransferase NSUN2; TRNA methyltransferase 4; TRNA methyltransferase 4 homolog
Type:
Methyltransferase; EC 2.1.1.-; EC 2.1.1.29
Mass (Da):
86471
Number AA:
767
UniProt ID:
Q08J23
International Prot ID:
IPI00306369
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0016428
GO:0000049
PhosphoSite+
KinaseNET
Biological Process:
GO:0030488
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y38
E
A
G
W
E
G
G
Y
P
E
I
V
K
E
N
Site 2
Y51
E
N
K
L
F
E
H
Y
Y
Q
E
L
K
I
V
Site 3
Y52
N
K
L
F
E
H
Y
Y
Q
E
L
K
I
V
P
Site 4
T77
L
R
E
P
L
P
A
T
L
R
I
T
G
Y
K
Site 5
T81
L
P
A
T
L
R
I
T
G
Y
K
S
H
A
K
Site 6
Y83
A
T
L
R
I
T
G
Y
K
S
H
A
K
E
I
Site 7
S85
L
R
I
T
G
Y
K
S
H
A
K
E
I
L
H
Site 8
Y98
L
H
C
L
K
N
K
Y
F
K
E
L
E
D
L
Site 9
S119
V
E
V
P
Q
P
L
S
W
Y
P
E
E
L
A
Site 10
Y121
V
P
Q
P
L
S
W
Y
P
E
E
L
A
W
H
Site 11
S139
S
R
K
I
L
R
K
S
P
H
L
E
K
F
H
Site 12
S151
K
F
H
Q
F
L
V
S
E
T
E
S
G
N
I
Site 13
S155
F
L
V
S
E
T
E
S
G
N
I
S
R
Q
E
Site 14
S159
E
T
E
S
G
N
I
S
R
Q
E
A
V
S
M
Site 15
S165
I
S
R
Q
E
A
V
S
M
I
P
P
L
L
L
Site 16
S189
D
M
C
A
A
P
G
S
K
T
T
Q
L
I
E
Site 17
Y222
D
V
D
N
K
R
C
Y
L
L
V
H
Q
A
K
Site 18
S233
H
Q
A
K
R
L
S
S
P
C
I
M
V
V
N
Site 19
S244
M
V
V
N
H
D
A
S
S
I
P
R
L
Q
I
Site 20
S245
V
V
N
H
D
A
S
S
I
P
R
L
Q
I
D
Site 21
S272
I
L
C
D
V
P
C
S
G
D
G
T
M
R
K
Site 22
T276
V
P
C
S
G
D
G
T
M
R
K
N
I
D
V
Site 23
T304
G
L
Q
L
R
I
A
T
R
G
A
E
Q
L
A
Site 24
Y318
A
E
G
G
R
M
V
Y
S
T
C
S
L
N
P
Site 25
S319
E
G
G
R
M
V
Y
S
T
C
S
L
N
P
I
Site 26
T320
G
G
R
M
V
Y
S
T
C
S
L
N
P
I
E
Site 27
S322
R
M
V
Y
S
T
C
S
L
N
P
I
E
D
E
Site 28
S334
E
D
E
A
V
I
A
S
L
L
E
K
S
E
G
Site 29
T386
A
V
P
H
S
R
H
T
Q
I
R
P
T
M
F
Site 30
T391
R
H
T
Q
I
R
P
T
M
F
P
P
K
D
P
Site 31
S431
V
A
V
L
V
K
K
S
S
M
P
W
N
K
R
Site 32
S432
A
V
L
V
K
K
S
S
M
P
W
N
K
R
Q
Site 33
T449
L
Q
G
K
S
A
E
T
R
E
S
T
Q
L
S
Site 34
S452
K
S
A
E
T
R
E
S
T
Q
L
S
P
A
D
Site 35
T453
S
A
E
T
R
E
S
T
Q
L
S
P
A
D
L
Site 36
S456
T
R
E
S
T
Q
L
S
P
A
D
L
T
E
G
Site 37
T461
Q
L
S
P
A
D
L
T
E
G
K
P
T
D
P
Site 38
T466
D
L
T
E
G
K
P
T
D
P
S
K
L
E
S
Site 39
S469
E
G
K
P
T
D
P
S
K
L
E
S
P
S
F
Site 40
S473
T
D
P
S
K
L
E
S
P
S
F
T
G
T
G
Site 41
S475
P
S
K
L
E
S
P
S
F
T
G
T
G
D
T
Site 42
T477
K
L
E
S
P
S
F
T
G
T
G
D
T
E
I
Site 43
T479
E
S
P
S
F
T
G
T
G
D
T
E
I
A
H
Site 44
S496
E
D
L
E
N
N
G
S
K
K
D
G
V
C
G
Site 45
S507
G
V
C
G
P
P
P
S
K
K
M
K
L
F
G
Site 46
S542
K
F
Y
A
L
D
P
S
F
P
R
M
N
L
L
Site 47
T550
F
P
R
M
N
L
L
T
R
T
T
E
G
K
K
Site 48
T553
M
N
L
L
T
R
T
T
E
G
K
K
R
Q
L
Site 49
Y561
E
G
K
K
R
Q
L
Y
M
V
S
K
E
L
R
Site 50
T583
E
K
M
K
V
I
N
T
G
I
K
V
W
C
R
Site 51
S593
K
V
W
C
R
N
N
S
G
E
E
F
D
C
A
Site 52
Y609
R
L
A
Q
E
G
I
Y
T
L
Y
P
F
I
N
Site 53
Y612
Q
E
G
I
Y
T
L
Y
P
F
I
N
S
R
I
Site 54
T632
E
D
V
K
I
L
L
T
Q
E
N
P
F
F
R
Site 55
S642
N
P
F
F
R
K
L
S
S
E
T
Y
S
Q
A
Site 56
S643
P
F
F
R
K
L
S
S
E
T
Y
S
Q
A
K
Site 57
Y646
R
K
L
S
S
E
T
Y
S
Q
A
K
D
L
A
Site 58
S647
K
L
S
S
E
T
Y
S
Q
A
K
D
L
A
K
Site 59
Y661
K
G
S
I
V
L
K
Y
E
P
D
S
A
N
P
Site 60
S665
V
L
K
Y
E
P
D
S
A
N
P
D
A
L
Q
Site 61
T688
R
G
K
A
S
I
R
T
F
V
P
K
N
E
R
Site 62
Y698
P
K
N
E
R
L
H
Y
L
R
M
M
G
L
E
Site 63
S721
G
V
I
L
T
N
E
S
A
A
S
T
G
Q
P
Site 64
S724
L
T
N
E
S
A
A
S
T
G
Q
P
D
N
D
Site 65
T725
T
N
E
S
A
A
S
T
G
Q
P
D
N
D
V
Site 66
T733
G
Q
P
D
N
D
V
T
E
G
Q
R
A
G
E
Site 67
S743
Q
R
A
G
E
P
N
S
P
D
A
E
E
A
N
Site 68
S751
P
D
A
E
E
A
N
S
P
D
V
T
A
G
C
Site 69
T755
E
A
N
S
P
D
V
T
A
G
C
D
P
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation