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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rb-like 2
Full Name:
Retinoblastoma-like protein 2
Alias:
130 kDa retinoblastoma-associated protein; P130; PRB2; RB2; RBL2; RBR-2; Retinoblastoma-like 2
Type:
Transcription, coactivator/corepressor
Mass (Da):
128367
Number AA:
1139
UniProt ID:
Q08999
International Prot ID:
IPI00304028
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0016568
GO:0043550
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
S
G
G
D
Q
S
P
P
P
P
P
P
P
Site 2
S21
P
P
P
A
A
A
A
S
D
E
E
E
E
D
D
Site 3
S40
D
A
A
P
P
A
E
S
P
T
P
Q
I
Q
Q
Site 4
T42
A
P
P
A
E
S
P
T
P
Q
I
Q
Q
R
F
Site 5
S69
A
R
A
E
A
W
D
S
Y
R
S
M
S
E
S
Site 6
Y70
R
A
E
A
W
D
S
Y
R
S
M
S
E
S
Y
Site 7
S72
E
A
W
D
S
Y
R
S
M
S
E
S
Y
T
L
Site 8
S74
W
D
S
Y
R
S
M
S
E
S
Y
T
L
E
G
Site 9
S76
S
Y
R
S
M
S
E
S
Y
T
L
E
G
N
D
Site 10
T78
R
S
M
S
E
S
Y
T
L
E
G
N
D
L
H
Site 11
S98
L
Y
V
A
C
R
K
S
V
P
T
V
S
K
G
Site 12
T101
A
C
R
K
S
V
P
T
V
S
K
G
T
V
E
Site 13
S103
R
K
S
V
P
T
V
S
K
G
T
V
E
G
N
Site 14
Y111
K
G
T
V
E
G
N
Y
V
S
L
T
R
I
L
Site 15
S113
T
V
E
G
N
Y
V
S
L
T
R
I
L
K
C
Site 16
T115
E
G
N
Y
V
S
L
T
R
I
L
K
C
S
E
Site 17
T149
P
P
H
F
R
E
R
T
E
R
L
E
R
N
F
Site 18
T157
E
R
L
E
R
N
F
T
V
S
A
V
I
F
K
Site 19
Y176
I
F
Q
D
I
F
K
Y
P
Q
E
E
Q
P
R
Site 20
T196
K
Q
R
R
Q
P
C
T
V
S
E
I
F
H
F
Site 21
S219
K
G
N
F
P
M
I
S
D
D
L
V
N
S
Y
Site 22
S244
Y
G
N
A
L
Q
C
S
N
R
K
E
L
V
N
Site 23
S266
E
D
F
H
A
K
D
S
K
P
S
S
D
P
P
Site 24
S270
A
K
D
S
K
P
S
S
D
P
P
C
I
I
E
Site 25
Y301
K
E
H
F
W
K
P
Y
I
R
K
L
Y
E
K
Site 26
Y306
K
P
Y
I
R
K
L
Y
E
K
K
L
L
K
G
Site 27
T319
K
G
K
E
E
N
L
T
G
F
L
E
P
G
N
Site 28
S330
E
P
G
N
F
G
E
S
F
K
A
I
N
K
A
Site 29
Y341
I
N
K
A
Y
E
E
Y
V
L
S
V
G
N
L
Site 30
S344
A
Y
E
E
Y
V
L
S
V
G
N
L
D
E
R
Site 31
T364
D
A
E
E
E
I
G
T
L
S
R
C
L
N
A
Site 32
S366
E
E
E
I
G
T
L
S
R
C
L
N
A
G
S
Site 33
S373
S
R
C
L
N
A
G
S
G
T
E
T
A
E
R
Site 34
T377
N
A
G
S
G
T
E
T
A
E
R
V
Q
M
K
Site 35
S394
L
Q
Q
H
F
D
K
S
K
A
L
R
I
S
T
Site 36
S400
K
S
K
A
L
R
I
S
T
P
L
T
G
V
R
Site 37
T401
S
K
A
L
R
I
S
T
P
L
T
G
V
R
Y
Site 38
T404
L
R
I
S
T
P
L
T
G
V
R
Y
I
K
E
Site 39
Y408
T
P
L
T
G
V
R
Y
I
K
E
N
S
P
C
Site 40
S413
V
R
Y
I
K
E
N
S
P
C
V
T
P
V
S
Site 41
T417
K
E
N
S
P
C
V
T
P
V
S
T
A
T
H
Site 42
T421
P
C
V
T
P
V
S
T
A
T
H
S
L
S
R
Site 43
T423
V
T
P
V
S
T
A
T
H
S
L
S
R
L
H
Site 44
S425
P
V
S
T
A
T
H
S
L
S
R
L
H
T
M
Site 45
S427
S
T
A
T
H
S
L
S
R
L
H
T
M
L
T
Site 46
T431
H
S
L
S
R
L
H
T
M
L
T
G
L
R
N
Site 47
T434
S
R
L
H
T
M
L
T
G
L
R
N
A
P
S
Site 48
S441
T
G
L
R
N
A
P
S
E
K
L
E
Q
I
L
Site 49
T450
K
L
E
Q
I
L
R
T
C
S
R
D
P
T
Q
Site 50
S452
E
Q
I
L
R
T
C
S
R
D
P
T
Q
A
I
Site 51
T456
R
T
C
S
R
D
P
T
Q
A
I
A
N
R
L
Site 52
Y470
L
K
E
M
F
E
I
Y
S
Q
H
F
Q
P
D
Site 53
S505
L
Y
Y
K
V
L
E
S
V
I
E
Q
E
Q
K
Site 54
S520
R
L
G
D
M
D
L
S
G
I
L
E
Q
D
A
Site 55
S531
E
Q
D
A
F
H
R
S
L
L
A
C
C
L
E
Site 56
Y544
L
E
V
V
T
F
S
Y
K
P
P
G
N
F
P
Site 57
S603
H
L
A
W
K
P
E
S
P
L
W
E
K
I
R
Site 58
T618
D
N
E
N
R
V
P
T
C
E
E
V
M
P
P
Site 59
S639
D
E
I
C
I
A
G
S
P
L
T
P
R
R
V
Site 60
T642
C
I
A
G
S
P
L
T
P
R
R
V
T
E
V
Site 61
T647
P
L
T
P
R
R
V
T
E
V
R
A
D
T
G
Site 62
T653
V
T
E
V
R
A
D
T
G
G
L
G
R
S
I
Site 63
S659
D
T
G
G
L
G
R
S
I
T
S
P
T
T
L
Site 64
T661
G
G
L
G
R
S
I
T
S
P
T
T
L
Y
D
Site 65
S662
G
L
G
R
S
I
T
S
P
T
T
L
Y
D
R
Site 66
T664
G
R
S
I
T
S
P
T
T
L
Y
D
R
Y
S
Site 67
T665
R
S
I
T
S
P
T
T
L
Y
D
R
Y
S
S
Site 68
Y667
I
T
S
P
T
T
L
Y
D
R
Y
S
S
P
P
Site 69
Y670
P
T
T
L
Y
D
R
Y
S
S
P
P
A
S
T
Site 70
S671
T
T
L
Y
D
R
Y
S
S
P
P
A
S
T
T
Site 71
S672
T
L
Y
D
R
Y
S
S
P
P
A
S
T
T
R
Site 72
S676
R
Y
S
S
P
P
A
S
T
T
R
R
R
L
F
Site 73
T677
Y
S
S
P
P
A
S
T
T
R
R
R
L
F
V
Site 74
T678
S
S
P
P
A
S
T
T
R
R
R
L
F
V
E
Site 75
S688
R
L
F
V
E
N
D
S
P
S
D
G
G
T
P
Site 76
S690
F
V
E
N
D
S
P
S
D
G
G
T
P
G
R
Site 77
T694
D
S
P
S
D
G
G
T
P
G
R
M
P
P
Q
Site 78
S718
N
V
S
G
E
T
V
S
V
T
P
V
P
G
Q
Site 79
T720
S
G
E
T
V
S
V
T
P
V
P
G
Q
T
L
Site 80
T758
A
N
E
N
G
G
I
T
F
F
P
V
Q
V
N
Site 81
S776
Q
A
Q
A
V
T
G
S
I
Q
P
L
S
A
Q
Site 82
S788
S
A
Q
A
L
A
G
S
L
S
S
Q
Q
V
T
Site 83
S790
Q
A
L
A
G
S
L
S
S
Q
Q
V
T
G
T
Site 84
T795
S
L
S
S
Q
Q
V
T
G
T
T
L
Q
V
P
Site 85
S811
Q
V
A
I
Q
Q
I
S
P
G
G
Q
Q
Q
K
Site 86
S822
Q
Q
Q
K
Q
G
Q
S
V
T
S
S
S
N
R
Site 87
S826
Q
G
Q
S
V
T
S
S
S
N
R
P
R
K
T
Site 88
S827
G
Q
S
V
T
S
S
S
N
R
P
R
K
T
S
Site 89
T833
S
S
N
R
P
R
K
T
S
S
L
S
L
F
F
Site 90
S834
S
N
R
P
R
K
T
S
S
L
S
L
F
F
R
Site 91
S835
N
R
P
R
K
T
S
S
L
S
L
F
F
R
K
Site 92
S837
P
R
K
T
S
S
L
S
L
F
F
R
K
V
Y
Site 93
S861
L
C
A
K
L
D
I
S
D
E
L
R
K
K
I
Site 94
Y916
F
Q
N
I
M
R
C
Y
R
T
Q
P
Q
A
R
Site 95
S924
R
T
Q
P
Q
A
R
S
Q
V
Y
R
S
V
L
Site 96
S929
A
R
S
Q
V
Y
R
S
V
L
I
K
G
K
R
Site 97
S941
G
K
R
K
R
R
N
S
G
S
S
D
S
R
S
Site 98
S943
R
K
R
R
N
S
G
S
S
D
S
R
S
H
Q
Site 99
S944
K
R
R
N
S
G
S
S
D
S
R
S
H
Q
N
Site 100
S946
R
N
S
G
S
S
D
S
R
S
H
Q
N
S
P
Site 101
S948
S
G
S
S
D
S
R
S
H
Q
N
S
P
T
E
Site 102
S952
D
S
R
S
H
Q
N
S
P
T
E
L
N
K
D
Site 103
T961
T
E
L
N
K
D
R
T
S
R
D
S
S
P
V
Site 104
S962
E
L
N
K
D
R
T
S
R
D
S
S
P
V
M
Site 105
S965
K
D
R
T
S
R
D
S
S
P
V
M
R
S
S
Site 106
S966
D
R
T
S
R
D
S
S
P
V
M
R
S
S
S
Site 107
S971
D
S
S
P
V
M
R
S
S
S
T
L
P
V
P
Site 108
S972
S
S
P
V
M
R
S
S
S
T
L
P
V
P
Q
Site 109
S973
S
P
V
M
R
S
S
S
T
L
P
V
P
Q
P
Site 110
T974
P
V
M
R
S
S
S
T
L
P
V
P
Q
P
S
Site 111
S981
T
L
P
V
P
Q
P
S
S
A
P
P
T
P
T
Site 112
S982
L
P
V
P
Q
P
S
S
A
P
P
T
P
T
R
Site 113
T986
Q
P
S
S
A
P
P
T
P
T
R
L
T
G
A
Site 114
T988
S
S
A
P
P
T
P
T
R
L
T
G
A
N
S
Site 115
T991
P
P
T
P
T
R
L
T
G
A
N
S
D
M
E
Site 116
S995
T
R
L
T
G
A
N
S
D
M
E
E
E
E
R
Site 117
Y1009
R
G
D
L
I
Q
F
Y
N
N
I
Y
I
K
Q
Site 118
T1019
I
Y
I
K
Q
I
K
T
F
A
M
K
Y
S
Q
Site 119
S1025
K
T
F
A
M
K
Y
S
Q
A
N
M
D
A
P
Site 120
S1035
N
M
D
A
P
P
L
S
P
Y
P
F
V
R
T
Site 121
Y1037
D
A
P
P
L
S
P
Y
P
F
V
R
T
G
S
Site 122
T1042
S
P
Y
P
F
V
R
T
G
S
P
R
R
I
Q
Site 123
S1044
Y
P
F
V
R
T
G
S
P
R
R
I
Q
L
S
Site 124
S1051
S
P
R
R
I
Q
L
S
Q
N
H
P
V
Y
I
Site 125
Y1057
L
S
Q
N
H
P
V
Y
I
S
P
H
K
N
E
Site 126
S1059
Q
N
H
P
V
Y
I
S
P
H
K
N
E
T
M
Site 127
T1065
I
S
P
H
K
N
E
T
M
L
S
P
R
E
K
Site 128
S1068
H
K
N
E
T
M
L
S
P
R
E
K
I
F
Y
Site 129
Y1075
S
P
R
E
K
I
F
Y
Y
F
S
N
S
P
S
Site 130
Y1076
P
R
E
K
I
F
Y
Y
F
S
N
S
P
S
K
Site 131
S1078
E
K
I
F
Y
Y
F
S
N
S
P
S
K
R
L
Site 132
S1080
I
F
Y
Y
F
S
N
S
P
S
K
R
L
R
E
Site 133
S1082
Y
Y
F
S
N
S
P
S
K
R
L
R
E
I
N
Site 134
S1090
K
R
L
R
E
I
N
S
M
I
R
T
G
E
T
Site 135
T1094
E
I
N
S
M
I
R
T
G
E
T
P
T
K
K
Site 136
T1097
S
M
I
R
T
G
E
T
P
T
K
K
R
G
I
Site 137
S1110
G
I
L
L
E
D
G
S
E
S
P
A
K
R
I
Site 138
S1112
L
L
E
D
G
S
E
S
P
A
K
R
I
C
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation