PhosphoNET

           
Protein Info 
   
Short Name:  MCL1
Full Name:  Induced myeloid leukemia cell differentiation protein Mcl-1
Alias:  BCL2L3; Bcl-2-related protein EAT/mcl1; EAT/MCL-1; Mcl-1; Mcl1/EAT; Myeloid cell leukemia sequence 1; Myeloid cell leukemia sequence 1 (BCL2-related)
Type:  Apoptosis; Channel, misc.; Mitochondrial; Inhibitor protein
Mass (Da):  37337
Number AA:  350
UniProt ID:  Q07820
International Prot ID:  IPI00030356
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021  GO:0005741  GO:0005739 Uniprot OncoNet
Molecular Function:  GO:0015266  GO:0046982   PhosphoSite+ KinaseNET
Biological Process:  GO:0006916  GO:0006915  GO:0001709 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T29GAGSGGATRPGGRLL
Site 2T38PGGRLLATEKEASAR
Site 3S43LATEKEASARREIGG
Site 4S60AGAVIGGSAGASPPS
Site 5S64IGGSAGASPPSTLTP
Site 6S67SAGASPPSTLTPDSR
Site 7T68AGASPPSTLTPDSRR
Site 8T70ASPPSTLTPDSRRVA
Site 9S73PSTLTPDSRRVARPP
Site 10T92EVPDVTATPARLLFF
Site 11S121PAADAIMSPEEELDG
Site 12Y129PEEELDGYEPEPLGK
Site 13S150LLELVGESGNNTSTD
Site 14T154VGESGNNTSTDGSLP
Site 15S155GESGNNTSTDGSLPS
Site 16T156ESGNNTSTDGSLPST
Site 17S159NNTSTDGSLPSTPPP
Site 18S162STDGSLPSTPPPAEE
Site 19T163TDGSLPSTPPPAEEE
Site 20Y175EEEEDELYRQSLEII
Site 21S178EDELYRQSLEIISRY
Site 22Y185SLEIISRYLREQATG
Site 23S206MGRSGATSRKALETL
Site 24T212TSRKALETLRRVGDG
Site 25S245KNEDDVKSLSRVMIH
Site 26S247EDDVKSLSRVMIHVF
Site 27T280FVAKHLKTINQESCI
Site 28T301ITDVLVRTKRDWLVK
Site 29Y347GVGAGLAYLIR____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation