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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FMR1
Full Name:
Fragile X mental retardation 1 protein
Alias:
FMRP
Type:
RNA-binding protein
Mass (Da):
71174
Number AA:
632
UniProt ID:
Q06787
International Prot ID:
IPI00412343
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005625
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0003729
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0007417
GO:0015931
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
R
G
S
N
G
A
F
Y
K
A
F
V
K
D
V
Site 2
S27
V
K
D
V
H
E
D
S
I
T
V
A
F
E
N
Site 3
T29
D
V
H
E
D
S
I
T
V
A
F
E
N
N
W
Site 4
S62
Y
N
K
D
I
N
E
S
D
E
V
E
V
Y
S
Site 5
Y68
E
S
D
E
V
E
V
Y
S
R
A
N
E
K
E
Site 6
Y96
G
E
F
Y
V
I
E
Y
A
A
C
D
A
T
Y
Site 7
Y103
Y
A
A
C
D
A
T
Y
N
E
I
V
T
I
E
Site 8
S114
V
T
I
E
R
L
R
S
V
N
P
N
K
P
A
Site 9
T125
N
K
P
A
T
K
D
T
F
H
K
I
K
L
D
Site 10
S158
K
K
A
V
G
A
F
S
V
T
Y
D
P
E
N
Site 11
T160
A
V
G
A
F
S
V
T
Y
D
P
E
N
Y
Q
Site 12
Y161
V
G
A
F
S
V
T
Y
D
P
E
N
Y
Q
L
Site 13
S197
R
S
L
R
T
K
L
S
L
I
M
R
N
E
E
Site 14
S206
I
M
R
N
E
E
A
S
K
Q
L
E
S
S
R
Site 15
S211
E
A
S
K
Q
L
E
S
S
R
Q
L
A
S
R
Site 16
Y265
D
T
C
T
F
H
I
Y
G
E
D
Q
D
A
V
Site 17
S277
D
A
V
K
K
A
R
S
F
L
E
F
A
E
D
Site 18
S337
E
E
I
M
P
P
N
S
L
P
S
N
N
S
R
Site 19
S340
M
P
P
N
S
L
P
S
N
N
S
R
V
G
P
Site 20
S343
N
S
L
P
S
N
N
S
R
V
G
P
N
A
P
Site 21
S362
H
L
D
I
K
E
N
S
T
H
F
S
Q
P
N
Site 22
S366
K
E
N
S
T
H
F
S
Q
P
N
S
T
K
V
Site 23
S370
T
H
F
S
Q
P
N
S
T
K
V
Q
R
V
L
Site 24
S387
S
S
V
V
A
G
E
S
Q
K
P
E
L
K
A
Site 25
Y419
N
A
T
V
L
L
D
Y
H
L
N
Y
L
K
E
Site 26
Y423
L
L
D
Y
H
L
N
Y
L
K
E
V
D
Q
L
Site 27
S447
Q
L
R
Q
I
G
A
S
S
R
P
P
P
N
R
Site 28
S448
L
R
Q
I
G
A
S
S
R
P
P
P
N
R
T
Site 29
T455
S
R
P
P
P
N
R
T
D
K
E
K
S
Y
V
Site 30
S460
N
R
T
D
K
E
K
S
Y
V
T
D
D
G
Q
Site 31
Y461
R
T
D
K
E
K
S
Y
V
T
D
D
G
Q
G
Site 32
T463
D
K
E
K
S
Y
V
T
D
D
G
Q
G
M
G
Site 33
S473
G
Q
G
M
G
R
G
S
R
P
Y
R
N
R
G
Site 34
Y476
M
G
R
G
S
R
P
Y
R
N
R
G
H
G
R
Site 35
Y488
H
G
R
R
G
P
G
Y
T
S
G
T
N
S
E
Site 36
T489
G
R
R
G
P
G
Y
T
S
G
T
N
S
E
A
Site 37
S490
R
R
G
P
G
Y
T
S
G
T
N
S
E
A
S
Site 38
T492
G
P
G
Y
T
S
G
T
N
S
E
A
S
N
A
Site 39
S494
G
Y
T
S
G
T
N
S
E
A
S
N
A
S
E
Site 40
S497
S
G
T
N
S
E
A
S
N
A
S
E
T
E
S
Site 41
S500
N
S
E
A
S
N
A
S
E
T
E
S
D
H
R
Site 42
T502
E
A
S
N
A
S
E
T
E
S
D
H
R
D
E
Site 43
S504
S
N
A
S
E
T
E
S
D
H
R
D
E
L
S
Site 44
S511
S
D
H
R
D
E
L
S
D
W
S
L
A
P
T
Site 45
S514
R
D
E
L
S
D
W
S
L
A
P
T
E
E
E
Site 46
T518
S
D
W
S
L
A
P
T
E
E
E
R
E
S
F
Site 47
S524
P
T
E
E
E
R
E
S
F
L
R
R
G
D
G
Site 48
S557
F
K
G
N
D
D
H
S
R
T
D
N
R
P
R
Site 49
T573
P
R
E
A
K
G
R
T
T
D
G
S
L
Q
I
Site 50
T574
R
E
A
K
G
R
T
T
D
G
S
L
Q
I
R
Site 51
S577
K
G
R
T
T
D
G
S
L
Q
I
R
V
D
C
Site 52
T594
E
R
S
V
H
T
K
T
L
Q
N
T
S
S
E
Site 53
S599
T
K
T
L
Q
N
T
S
S
E
G
S
R
L
R
Site 54
S600
K
T
L
Q
N
T
S
S
E
G
S
R
L
R
T
Site 55
S603
Q
N
T
S
S
E
G
S
R
L
R
T
G
K
D
Site 56
T607
S
E
G
S
R
L
R
T
G
K
D
R
N
Q
K
Site 57
S620
Q
K
K
E
K
P
D
S
V
D
G
Q
Q
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation