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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EXOSC9
Full Name:
Exosome complex exonuclease RRP45
Alias:
Autoantigen PM/Scl 1; EC 3.1.13.-; EXOS9; Exosome component 9; p75 polymyositis-scleroderma overlap syndrome associated autoantigen; PM/Scl-75; PMSCL autoantigen, 75kD; PMSCL1; RRP45; Rrp45p
Type:
Enzyme - RNase. RNase PH family.
Mass (Da):
48949
Number AA:
439
UniProt ID:
Q06265
International Prot ID:
IPI00654592
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000176
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0000175
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0006364
GO:0006364
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
K
E
T
P
L
S
N
C
E
R
R
F
L
Site 2
T29
K
R
L
D
G
R
Q
T
Y
D
Y
R
N
I
R
Site 3
Y30
R
L
D
G
R
Q
T
Y
D
Y
R
N
I
R
I
Site 4
Y32
D
G
R
Q
T
Y
D
Y
R
N
I
R
I
S
F
Site 5
S65
Q
V
S
C
E
L
V
S
P
K
L
N
R
A
T
Site 6
T72
S
P
K
L
N
R
A
T
E
G
I
L
F
F
N
Site 7
S96
A
F
E
P
G
R
Q
S
D
L
L
V
K
L
N
Site 8
S113
M
E
R
C
L
R
N
S
K
C
I
D
T
E
S
Site 9
S166
H
F
R
R
P
D
V
S
V
Q
G
D
E
V
T
Site 10
T173
S
V
Q
G
D
E
V
T
L
Y
T
P
E
E
R
Site 11
Y175
Q
G
D
E
V
T
L
Y
T
P
E
E
R
D
P
Site 12
T176
G
D
E
V
T
L
Y
T
P
E
E
R
D
P
V
Site 13
S186
E
R
D
P
V
P
L
S
I
H
H
M
P
I
C
Site 14
Y204
A
F
F
Q
Q
G
T
Y
L
L
V
D
P
N
E
Site 15
T233
N
K
H
R
E
I
C
T
I
Q
S
S
G
G
I
Site 16
S251
K
D
Q
V
L
R
C
S
K
I
A
G
V
K
V
Site 17
S287
G
K
F
G
F
A
E
S
I
A
N
Q
R
I
T
Site 18
T294
S
I
A
N
Q
R
I
T
A
F
K
M
E
K
A
Site 19
T305
M
E
K
A
P
I
D
T
S
D
V
E
E
K
A
Site 20
S306
E
K
A
P
I
D
T
S
D
V
E
E
K
A
E
Site 21
S327
E
P
P
S
E
V
V
S
T
P
V
L
W
T
P
Site 22
S346
I
G
E
G
V
E
N
S
W
G
D
L
E
D
S
Site 23
S353
S
W
G
D
L
E
D
S
E
K
E
D
D
E
G
Site 24
S380
M
D
T
G
V
E
V
S
D
I
G
S
Q
D
A
Site 25
S392
Q
D
A
P
I
I
L
S
D
S
E
E
E
E
M
Site 26
S394
A
P
I
I
L
S
D
S
E
E
E
E
M
I
I
Site 27
T413
K
N
P
K
K
I
R
T
Q
T
T
S
A
K
Q
Site 28
T415
P
K
K
I
R
T
Q
T
T
S
A
K
Q
E
K
Site 29
S417
K
I
R
T
Q
T
T
S
A
K
Q
E
K
A
P
Site 30
S425
A
K
Q
E
K
A
P
S
K
K
P
V
K
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation