PhosphoNET

           
Protein Info 
   
Short Name:  PTPN11
Full Name:  Tyrosine-protein phosphatase non-receptor type 11
Alias:  BPTP3; EC 3.1.3.48; NS1; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase, non-receptor 11; PTN11; PTP1D; PTP-1D; PTP2C; PTP-2C; SHP2; SHPTP2; SH-PTP2; SH-PTP3; Syp
Type:  EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):  68436
Number AA:  597
UniProt ID:  Q06124
International Prot ID:  IPI00658023
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829     Uniprot OncoNet
Molecular Function:  GO:0004726  GO:0005515   PhosphoSite+ KinaseNET
Biological Process:  GO:0006470     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S28LTRGVDGSFLARPSK
Site 2S34GSFLARPSKSNPGDF
Site 3S36FLARPSKSNPGDFTL
Site 4T42KSNPGDFTLSVRRNG
Site 5S44NPGDFTLSVRRNGAV
Site 6T52VRRNGAVTHIKIQNT
Site 7T59THIKIQNTGDYYDLY
Site 8Y62KIQNTGDYYDLYGGE
Site 9Y63IQNTGDYYDLYGGEK
Site 10Y66TGDYYDLYGGEKFAT
Site 11T73YGGEKFATLAELVQY
Site 12Y80TLAELVQYYMEHHGQ
Site 13Y81LAELVQYYMEHHGQL
Site 14Y100GDVIELKYPLNCADP
Site 15T108PLNCADPTSERWFHG
Site 16S118RWFHGHLSGKEAEKL
Site 17T127KEAEKLLTEKGKHGS
Site 18S134TEKGKHGSFLVRESQ
Site 19S140GSFLVRESQSHPGDF
Site 20S142FLVRESQSHPGDFVL
Site 21S150HPGDFVLSVRTGDDK
Site 22T153DFVLSVRTGDDKGES
Site 23S160TGDDKGESNDGKSKV
Site 24S165GESNDGKSKVTHVMI
Site 25Y179IRCQELKYDVGGGER
Site 26S189GGGERFDSLTDLVEH
Site 27T191GERFDSLTDLVEHYK
Site 28S228INAAEIESRVRELSK
Site 29S234ESRVRELSKLAETTD
Site 30Y263QQECKLLYSRKEGQR
Site 31Y279ENKNKNRYKNILPFD
Site 32T288NILPFDHTRVVLHDG
Site 33S302GDPNEPVSDYINANI
Site 34Y304PNEPVSDYINANIIM
Site 35S321FETKCNNSKPKKSYI
Site 36S326NNSKPKKSYIATQGC
Site 37Y327NSKPKKSYIATQGCL
Site 38T330PKKSYIATQGCLQNT
Site 39T356NSRVIVMTTKEVERG
Site 40S365KEVERGKSKCVKYWP
Site 41Y370GKSKCVKYWPDEYAL
Site 42Y375VKYWPDEYALKEYGV
Site 43S391RVRNVKESAAHDYTL
Site 44Y396KESAAHDYTLRELKL
Site 45T397ESAAHDYTLRELKLS
Site 46T415QALLQGNTERTVWQY
Site 47S434WPDHGVPSDPGGVLD
Site 48T497CDIDVPKTIQMVRSQ
Site 49S503KTIQMVRSQRSGMVQ
Site 50Y515MVQTEAQYRFIYMAV
Site 51Y519EAQYRFIYMAVQHYI
Site 52S539RIEEEQKSKRKGHEY
Site 53Y546SKRKGHEYTNIKYSL
Site 54T547KRKGHEYTNIKYSLA
Site 55Y551HEYTNIKYSLADQTS
Site 56S552EYTNIKYSLADQTSG
Site 57T557KYSLADQTSGDQSPL
Site 58S558YSLADQTSGDQSPLP
Site 59S562DQTSGDQSPLPPCTP
Site 60T568QSPLPPCTPTPPCAE
Site 61T570PLPPCTPTPPCAEMR
Site 62S580CAEMREDSARVYENV
Site 63Y584REDSARVYENVGLMQ
Site 64S595GLMQQQKSFR_____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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