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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LIPE
Full Name:
Hormone-sensitive lipase
Alias:
Hormone sensitive lipase; HSL; Lipase, hormone-sensitive; LIPS
Type:
EC 3.1.1.79; Lipase
Mass (Da):
116598
Number AA:
775
UniProt ID:
Q05469
International Prot ID:
IPI00643204
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005901
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0033878
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008203
GO:0006468
GO:0042493
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
P
G
S
K
S
V
S
R
S
D
Site 2
S7
_
M
E
P
G
S
K
S
V
S
R
S
D
W
Q
Site 3
S9
E
P
G
S
K
S
V
S
R
S
D
W
Q
P
E
Site 4
S11
G
S
K
S
V
S
R
S
D
W
Q
P
E
P
H
Site 5
T23
E
P
H
Q
R
P
I
T
P
L
E
P
G
P
E
Site 6
T32
L
E
P
G
P
E
K
T
P
I
A
Q
P
E
S
Site 7
S39
T
P
I
A
Q
P
E
S
K
T
L
Q
G
S
N
Site 8
T41
I
A
Q
P
E
S
K
T
L
Q
G
S
N
T
Q
Site 9
T47
K
T
L
Q
G
S
N
T
Q
Q
K
P
A
S
N
Site 10
S53
N
T
Q
Q
K
P
A
S
N
Q
R
P
L
T
Q
Site 11
T59
A
S
N
Q
R
P
L
T
Q
Q
E
T
P
A
Q
Site 12
T63
R
P
L
T
Q
Q
E
T
P
A
Q
H
D
A
E
Site 13
S71
P
A
Q
H
D
A
E
S
Q
K
E
P
R
A
Q
Site 14
S81
E
P
R
A
Q
Q
K
S
A
S
Q
E
E
F
L
Site 15
S83
R
A
Q
Q
K
S
A
S
Q
E
E
F
L
A
P
Site 16
S98
Q
K
P
A
P
Q
Q
S
P
Y
I
Q
R
V
L
Site 17
Y100
P
A
P
Q
Q
S
P
Y
I
Q
R
V
L
L
T
Site 18
S113
L
T
Q
Q
E
A
A
S
Q
Q
G
P
G
L
G
Site 19
T156
A
Q
Q
E
A
E
S
T
P
A
A
Q
A
K
P
Site 20
S170
P
G
A
K
R
E
P
S
A
P
T
E
S
T
S
Site 21
S175
E
P
S
A
P
T
E
S
T
S
Q
E
T
P
E
Site 22
S177
S
A
P
T
E
S
T
S
Q
E
T
P
E
Q
S
Site 23
T180
T
E
S
T
S
Q
E
T
P
E
Q
S
D
K
Q
Site 24
S184
S
Q
E
T
P
E
Q
S
D
K
Q
T
T
P
V
Site 25
T188
P
E
Q
S
D
K
Q
T
T
P
V
Q
G
A
K
Site 26
T189
E
Q
S
D
K
Q
T
T
P
V
Q
G
A
K
S
Site 27
S196
T
P
V
Q
G
A
K
S
K
Q
G
S
L
T
E
Site 28
S200
G
A
K
S
K
Q
G
S
L
T
E
L
G
F
L
Site 29
T202
K
S
K
Q
G
S
L
T
E
L
G
F
L
T
K
Site 30
S214
L
T
K
L
Q
E
L
S
I
Q
R
S
A
L
E
Site 31
S218
Q
E
L
S
I
Q
R
S
A
L
E
W
K
A
L
Site 32
T230
K
A
L
S
E
W
V
T
D
S
E
S
E
S
D
Site 33
S232
L
S
E
W
V
T
D
S
E
S
E
S
D
V
G
Site 34
S234
E
W
V
T
D
S
E
S
E
S
D
V
G
S
S
Site 35
S236
V
T
D
S
E
S
E
S
D
V
G
S
S
S
D
Site 36
S240
E
S
E
S
D
V
G
S
S
S
D
T
D
S
P
Site 37
S242
E
S
D
V
G
S
S
S
D
T
D
S
P
A
T
Site 38
T244
D
V
G
S
S
S
D
T
D
S
P
A
T
M
G
Site 39
S246
G
S
S
S
D
T
D
S
P
A
T
M
G
G
M
Site 40
S266
K
L
G
F
K
G
K
S
G
Y
K
V
M
S
G
Site 41
Y268
G
F
K
G
K
S
G
Y
K
V
M
S
G
Y
S
Site 42
S272
K
S
G
Y
K
V
M
S
G
Y
S
G
T
S
P
Site 43
Y274
G
Y
K
V
M
S
G
Y
S
G
T
S
P
H
E
Site 44
S278
M
S
G
Y
S
G
T
S
P
H
E
K
T
S
A
Site 45
T283
G
T
S
P
H
E
K
T
S
A
R
N
H
R
H
Site 46
S284
T
S
P
H
E
K
T
S
A
R
N
H
R
H
Y
Site 47
Y291
S
A
R
N
H
R
H
Y
Q
D
T
A
S
R
L
Site 48
T306
I
H
N
M
D
L
R
T
M
T
Q
S
L
V
T
Site 49
S310
D
L
R
T
M
T
Q
S
L
V
T
L
A
E
D
Site 50
T313
T
M
T
Q
S
L
V
T
L
A
E
D
N
I
A
Site 51
S324
D
N
I
A
F
F
S
S
Q
G
P
G
E
T
A
Site 52
T330
S
S
Q
G
P
G
E
T
A
Q
R
L
S
G
V
Site 53
S335
G
E
T
A
Q
R
L
S
G
V
F
A
G
V
R
Site 54
T368
L
F
D
L
D
P
E
T
P
A
N
G
Y
R
S
Site 55
S375
T
P
A
N
G
Y
R
S
L
V
H
T
A
R
C
Site 56
S391
L
A
H
L
L
H
K
S
R
Y
V
A
S
N
R
Site 57
Y393
H
L
L
H
K
S
R
Y
V
A
S
N
R
R
S
Site 58
S396
H
K
S
R
Y
V
A
S
N
R
R
S
I
F
F
Site 59
S400
Y
V
A
S
N
R
R
S
I
F
F
R
T
S
H
Site 60
S406
R
S
I
F
F
R
T
S
H
N
L
A
E
L
E
Site 61
Y457
T
A
D
F
L
R
E
Y
V
T
L
H
K
G
C
Site 62
Y466
T
L
H
K
G
C
F
Y
G
R
C
L
G
F
Q
Site 63
S491
T
I
S
I
G
L
V
S
F
G
E
H
Y
K
R
Site 64
Y496
L
V
S
F
G
E
H
Y
K
R
N
E
T
G
L
Site 65
T501
E
H
Y
K
R
N
E
T
G
L
S
V
A
A
S
Site 66
S504
K
R
N
E
T
G
L
S
V
A
A
S
S
L
F
Site 67
T531
G
A
E
F
E
R
I
T
Q
N
L
D
V
H
F
Site 68
S552
I
A
E
P
M
R
R
S
V
S
E
A
A
L
A
Site 69
S553
T
E
M
E
V
L
S
S
L
A
N
M
A
S
A
Site 70
S559
S
S
L
A
N
M
A
S
A
T
V
R
V
S
R
Site 71
S565
A
S
A
T
V
R
V
S
R
L
L
S
L
P
P
Site 72
S607
P
V
L
V
R
L
I
S
Y
D
L
R
E
G
Q
Site 73
Y608
V
L
V
R
L
I
S
Y
D
L
R
E
G
Q
D
Site 74
S616
D
L
R
E
G
Q
D
S
E
E
L
S
S
L
I
Site 75
S620
G
Q
D
S
E
E
L
S
S
L
I
K
S
N
G
Site 76
S621
Q
D
S
E
E
L
S
S
L
I
K
S
N
G
Q
Site 77
S625
E
L
S
S
L
I
K
S
N
G
Q
R
S
L
E
Site 78
S630
I
K
S
N
G
Q
R
S
L
E
L
W
P
R
P
Site 79
S643
R
P
Q
Q
A
P
R
S
R
S
L
I
V
H
F
Site 80
S645
Q
Q
A
P
R
S
R
S
L
I
V
H
F
H
G
Site 81
T659
G
G
G
F
V
A
Q
T
S
R
S
H
E
P
Y
Site 82
S660
G
G
F
V
A
Q
T
S
R
S
H
E
P
Y
L
Site 83
S662
F
V
A
Q
T
S
R
S
H
E
P
Y
L
K
S
Site 84
Y666
T
S
R
S
H
E
P
Y
L
K
S
W
A
Q
E
Site 85
S669
S
H
E
P
Y
L
K
S
W
A
Q
E
L
G
A
Site 86
Y741
V
A
L
R
A
A
A
Y
G
V
R
V
P
D
G
Site 87
T792
S
A
Y
A
G
A
K
T
E
D
H
S
N
S
D
Site 88
S798
K
T
E
D
H
S
N
S
D
Q
K
A
L
G
M
Site 89
S826
D
F
R
L
G
A
S
S
W
L
N
S
F
L
E
Site 90
S830
G
A
S
S
W
L
N
S
F
L
E
L
S
G
R
Site 91
S835
L
N
S
F
L
E
L
S
G
R
K
S
Q
K
M
Site 92
S839
L
E
L
S
G
R
K
S
Q
K
M
S
E
P
I
Site 93
S843
G
R
K
S
Q
K
M
S
E
P
I
A
E
P
M
Site 94
S853
I
A
E
P
M
R
R
S
V
S
E
A
A
L
A
Site 95
S855
E
P
M
R
R
S
V
S
E
A
A
L
A
Q
P
Site 96
S870
Q
G
P
L
G
T
D
S
L
K
N
L
T
L
R
Site 97
T875
T
D
S
L
K
N
L
T
L
R
D
L
S
L
R
Site 98
S880
N
L
T
L
R
D
L
S
L
R
G
N
S
E
T
Site 99
S885
D
L
S
L
R
G
N
S
E
T
S
S
D
T
P
Site 100
T887
S
L
R
G
N
S
E
T
S
S
D
T
P
E
M
Site 101
S889
R
G
N
S
E
T
S
S
D
T
P
E
M
S
L
Site 102
T891
N
S
E
T
S
S
D
T
P
E
M
S
L
S
A
Site 103
S895
S
S
D
T
P
E
M
S
L
S
A
E
T
L
S
Site 104
S897
D
T
P
E
M
S
L
S
A
E
T
L
S
P
S
Site 105
T900
E
M
S
L
S
A
E
T
L
S
P
S
T
P
S
Site 106
S902
S
L
S
A
E
T
L
S
P
S
T
P
S
D
V
Site 107
S904
S
A
E
T
L
S
P
S
T
P
S
D
V
N
F
Site 108
T905
A
E
T
L
S
P
S
T
P
S
D
V
N
F
L
Site 109
S907
T
L
S
P
S
T
P
S
D
V
N
F
L
L
P
Site 110
S929
A
E
A
K
N
E
L
S
P
M
D
R
G
L
G
Site 111
S950
E
G
F
H
P
R
R
S
S
Q
G
A
T
Q
M
Site 112
S951
G
F
H
P
R
R
S
S
Q
G
A
T
Q
M
P
Site 113
T955
R
R
S
S
Q
G
A
T
Q
M
P
L
Y
S
S
Site 114
Y960
G
A
T
Q
M
P
L
Y
S
S
P
I
V
K
N
Site 115
S961
A
T
Q
M
P
L
Y
S
S
P
I
V
K
N
P
Site 116
S962
T
Q
M
P
L
Y
S
S
P
I
V
K
N
P
F
Site 117
S978
S
P
L
L
A
P
D
S
M
L
K
S
L
P
P
Site 118
T1015
R
N
L
G
Q
P
V
T
L
R
V
V
E
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation