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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTHR
Full Name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alias:
Parathyroid hormone 1 receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTHR1
Type:
Receptor, GPCR
Mass (Da):
66361
Number AA:
593
UniProt ID:
Q03431
International Prot ID:
IPI00010732
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005887
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004991
PhosphoSite+
KinaseNET
Biological Process:
GO:0007187
GO:0001501
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
C
P
V
L
S
S
A
Y
A
L
V
D
A
D
D
Site 2
S61
E
V
L
Q
R
P
A
S
I
M
E
S
D
K
G
Site 3
S65
R
P
A
S
I
M
E
S
D
K
G
W
T
S
A
Site 4
S71
E
S
D
K
G
W
T
S
A
S
T
S
G
K
P
Site 5
S73
D
K
G
W
T
S
A
S
T
S
G
K
P
R
K
Site 6
S75
G
W
T
S
A
S
T
S
G
K
P
R
K
D
K
Site 7
S84
K
P
R
K
D
K
A
S
G
K
L
Y
P
E
S
Site 8
Y88
D
K
A
S
G
K
L
Y
P
E
S
E
E
D
K
Site 9
S91
S
G
K
L
Y
P
E
S
E
E
D
K
E
A
P
Site 10
T99
E
E
D
K
E
A
P
T
G
S
R
Y
R
G
R
Site 11
S101
D
K
E
A
P
T
G
S
R
Y
R
G
R
P
C
Site 12
Y134
V
A
V
P
C
P
D
Y
I
Y
D
F
N
H
K
Site 13
Y136
V
P
C
P
D
Y
I
Y
D
F
N
H
K
G
H
Site 14
Y145
F
N
H
K
G
H
A
Y
R
R
C
D
R
N
G
Site 15
S153
R
R
C
D
R
N
G
S
W
E
L
V
P
G
H
Site 16
T163
L
V
P
G
H
N
R
T
W
A
N
Y
S
E
C
Site 17
Y167
H
N
R
T
W
A
N
Y
S
E
C
V
K
F
L
Site 18
T192
D
R
L
G
M
I
Y
T
V
G
Y
S
V
S
L
Site 19
T257
L
D
E
A
E
R
L
T
E
E
E
L
R
A
I
Site 20
Y320
A
F
F
S
E
K
K
Y
L
W
G
F
T
V
F
Site 21
T392
L
A
T
K
L
R
E
T
N
A
G
R
C
D
T
Site 22
T399
T
N
A
G
R
C
D
T
R
Q
Q
Y
R
K
L
Site 23
Y403
R
C
D
T
R
Q
Q
Y
R
K
L
L
K
S
T
Site 24
S473
V
Q
A
E
I
K
K
S
W
S
R
W
T
L
A
Site 25
S475
A
E
I
K
K
S
W
S
R
W
T
L
A
L
D
Site 26
T478
K
K
S
W
S
R
W
T
L
A
L
D
F
K
R
Site 27
S489
D
F
K
R
K
A
R
S
G
S
S
S
Y
S
Y
Site 28
S491
K
R
K
A
R
S
G
S
S
S
Y
S
Y
G
P
Site 29
S492
R
K
A
R
S
G
S
S
S
Y
S
Y
G
P
M
Site 30
S493
K
A
R
S
G
S
S
S
Y
S
Y
G
P
M
V
Site 31
S495
R
S
G
S
S
S
Y
S
Y
G
P
M
V
S
H
Site 32
Y496
S
G
S
S
S
Y
S
Y
G
P
M
V
S
H
T
Site 33
S501
Y
S
Y
G
P
M
V
S
H
T
S
V
T
N
V
Site 34
S504
G
P
M
V
S
H
T
S
V
T
N
V
G
P
R
Site 35
T527
P
R
L
L
P
T
A
T
T
N
G
H
P
Q
L
Site 36
T542
P
G
H
A
K
P
G
T
P
A
L
E
T
L
E
Site 37
T547
P
G
T
P
A
L
E
T
L
E
T
T
P
P
A
Site 38
S567
D
D
G
F
L
N
G
S
C
S
G
L
D
E
E
Site 39
S569
G
F
L
N
G
S
C
S
G
L
D
E
E
A
S
Site 40
S576
S
G
L
D
E
E
A
S
G
P
E
R
P
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation