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Updated November 2019
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Protein Info
Short Name:
CENPC1
Full Name:
Centromere protein C 1
Alias:
CENPC; CENP-C; Centromere autoantigen C; MIF2
Type:
Mass (Da):
106926
Number AA:
943
UniProt ID:
Q03188
International Prot ID:
IPI00304885
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003696
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
L
D
H
L
K
N
G
Y
R
R
R
F
C
R
P
Site 2
S21
R
R
R
F
C
R
P
S
R
A
R
D
I
N
T
Site 3
T28
S
R
A
R
D
I
N
T
E
Q
G
Q
N
V
L
Site 4
S46
Q
D
C
F
E
E
K
S
L
A
N
D
F
S
T
Site 5
S52
K
S
L
A
N
D
F
S
T
N
S
T
K
S
V
Site 6
T53
S
L
A
N
D
F
S
T
N
S
T
K
S
V
P
Site 7
S55
A
N
D
F
S
T
N
S
T
K
S
V
P
N
S
Site 8
T56
N
D
F
S
T
N
S
T
K
S
V
P
N
S
T
Site 9
S58
F
S
T
N
S
T
K
S
V
P
N
S
T
R
K
Site 10
S62
S
T
K
S
V
P
N
S
T
R
K
I
K
D
T
Site 11
T63
T
K
S
V
P
N
S
T
R
K
I
K
D
T
C
Site 12
T69
S
T
R
K
I
K
D
T
C
I
Q
S
P
S
K
Site 13
S73
I
K
D
T
C
I
Q
S
P
S
K
E
C
Q
K
Site 14
S75
D
T
C
I
Q
S
P
S
K
E
C
Q
K
S
H
Site 15
S81
P
S
K
E
C
Q
K
S
H
P
K
S
V
P
V
Site 16
S85
C
Q
K
S
H
P
K
S
V
P
V
S
S
K
K
Site 17
S89
H
P
K
S
V
P
V
S
S
K
K
K
E
A
S
Site 18
S90
P
K
S
V
P
V
S
S
K
K
K
E
A
S
L
Site 19
S96
S
S
K
K
K
E
A
S
L
Q
F
V
V
E
P
Site 20
T123
V
H
Q
K
I
L
A
T
D
V
S
S
K
N
T
Site 21
S126
K
I
L
A
T
D
V
S
S
K
N
T
P
D
S
Site 22
T130
T
D
V
S
S
K
N
T
P
D
S
K
K
I
S
Site 23
S133
S
S
K
N
T
P
D
S
K
K
I
S
S
R
N
Site 24
S137
T
P
D
S
K
K
I
S
S
R
N
I
N
D
H
Site 25
S146
R
N
I
N
D
H
H
S
E
A
D
E
E
F
Y
Site 26
Y153
S
E
A
D
E
E
F
Y
L
S
V
G
S
P
S
Site 27
S158
E
F
Y
L
S
V
G
S
P
S
V
L
L
D
A
Site 28
T167
S
V
L
L
D
A
K
T
S
V
S
Q
N
V
I
Site 29
S170
L
D
A
K
T
S
V
S
Q
N
V
I
P
S
S
Site 30
S177
S
Q
N
V
I
P
S
S
A
K
K
R
E
T
Y
Site 31
T183
S
S
A
K
K
R
E
T
Y
T
F
E
N
S
V
Site 32
Y184
S
A
K
K
R
E
T
Y
T
F
E
N
S
V
N
Site 33
T185
A
K
K
R
E
T
Y
T
F
E
N
S
V
N
M
Site 34
S189
E
T
Y
T
F
E
N
S
V
N
M
L
P
S
S
Site 35
S195
N
S
V
N
M
L
P
S
S
T
E
V
S
V
K
Site 36
S196
S
V
N
M
L
P
S
S
T
E
V
S
V
K
T
Site 37
S200
L
P
S
S
T
E
V
S
V
K
T
K
K
R
L
Site 38
T203
S
T
E
V
S
V
K
T
K
K
R
L
N
F
D
Site 39
S225
I
E
I
D
N
K
V
S
D
E
E
D
K
T
S
Site 40
T231
V
S
D
E
E
D
K
T
S
E
G
Q
E
R
K
Site 41
S232
S
D
E
E
D
K
T
S
E
G
Q
E
R
K
P
Site 42
S240
E
G
Q
E
R
K
P
S
G
S
S
Q
N
R
I
Site 43
S242
Q
E
R
K
P
S
G
S
S
Q
N
R
I
R
D
Site 44
S243
E
R
K
P
S
G
S
S
Q
N
R
I
R
D
S
Site 45
S250
S
Q
N
R
I
R
D
S
E
Y
E
I
Q
R
Q
Site 46
Y252
N
R
I
R
D
S
E
Y
E
I
Q
R
Q
A
K
Site 47
S261
I
Q
R
Q
A
K
K
S
F
S
T
L
F
L
E
Site 48
T264
Q
A
K
K
S
F
S
T
L
F
L
E
T
V
K
Site 49
T269
F
S
T
L
F
L
E
T
V
K
R
K
S
E
S
Site 50
S274
L
E
T
V
K
R
K
S
E
S
S
P
I
V
R
Site 51
S276
T
V
K
R
K
S
E
S
S
P
I
V
R
H
A
Site 52
S277
V
K
R
K
S
E
S
S
P
I
V
R
H
A
A
Site 53
T285
P
I
V
R
H
A
A
T
A
P
P
H
S
C
P
Site 54
S290
A
A
T
A
P
P
H
S
C
P
P
D
D
T
K
Site 55
T296
H
S
C
P
P
D
D
T
K
L
I
E
D
E
F
Site 56
S308
D
E
F
I
I
D
E
S
D
Q
S
F
A
S
R
Site 57
S311
I
I
D
E
S
D
Q
S
F
A
S
R
S
W
I
Site 58
S314
E
S
D
Q
S
F
A
S
R
S
W
I
T
I
P
Site 59
S316
D
Q
S
F
A
S
R
S
W
I
T
I
P
R
K
Site 60
S326
T
I
P
R
K
A
G
S
L
K
Q
R
T
I
S
Site 61
T331
A
G
S
L
K
Q
R
T
I
S
P
A
E
S
T
Site 62
S333
S
L
K
Q
R
T
I
S
P
A
E
S
T
A
L
Site 63
S337
R
T
I
S
P
A
E
S
T
A
L
F
Q
G
R
Site 64
S346
A
L
F
Q
G
R
K
S
R
E
K
H
H
N
I
Site 65
T357
H
H
N
I
L
P
K
T
L
A
N
D
K
H
S
Site 66
S364
T
L
A
N
D
K
H
S
H
K
P
H
P
V
E
Site 67
S373
K
P
H
P
V
E
T
S
Q
P
S
D
K
T
V
Site 68
S376
P
V
E
T
S
Q
P
S
D
K
T
V
L
D
T
Site 69
T379
T
S
Q
P
S
D
K
T
V
L
D
T
S
Y
A
Site 70
T391
S
Y
A
L
I
D
E
T
V
N
N
Y
R
S
T
Site 71
S397
E
T
V
N
N
Y
R
S
T
K
Y
E
M
Y
S
Site 72
T398
T
V
N
N
Y
R
S
T
K
Y
E
M
Y
S
K
Site 73
Y400
N
N
Y
R
S
T
K
Y
E
M
Y
S
K
N
A
Site 74
S411
S
K
N
A
E
K
P
S
R
S
K
R
T
I
K
Site 75
S413
N
A
E
K
P
S
R
S
K
R
T
I
K
Q
K
Site 76
S439
E
Q
L
D
V
G
Q
S
K
D
E
N
I
H
T
Site 77
T446
S
K
D
E
N
I
H
T
S
H
I
T
Q
D
E
Site 78
S458
Q
D
E
F
Q
R
N
S
D
R
N
M
E
E
H
Site 79
S483
K
Q
M
P
P
V
G
S
K
K
S
S
T
R
K
Site 80
S486
P
P
V
G
S
K
K
S
S
T
R
K
D
K
E
Site 81
S487
P
V
G
S
K
K
S
S
T
R
K
D
K
E
E
Site 82
S501
E
S
K
K
K
R
F
S
S
E
S
K
N
K
L
Site 83
S502
S
K
K
K
R
F
S
S
E
S
K
N
K
L
V
Site 84
S504
K
K
R
F
S
S
E
S
K
N
K
L
V
P
E
Site 85
S515
L
V
P
E
E
V
T
S
T
V
T
K
S
R
R
Site 86
T516
V
P
E
E
V
T
S
T
V
T
K
S
R
R
I
Site 87
S520
V
T
S
T
V
T
K
S
R
R
I
S
R
R
P
Site 88
S524
V
T
K
S
R
R
I
S
R
R
P
S
D
W
W
Site 89
S528
R
R
I
S
R
R
P
S
D
W
W
V
V
K
S
Site 90
S535
S
D
W
W
V
V
K
S
E
E
S
P
V
Y
S
Site 91
S538
W
V
V
K
S
E
E
S
P
V
Y
S
N
S
S
Site 92
Y541
K
S
E
E
S
P
V
Y
S
N
S
S
V
R
N
Site 93
S542
S
E
E
S
P
V
Y
S
N
S
S
V
R
N
E
Site 94
S544
E
S
P
V
Y
S
N
S
S
V
R
N
E
L
P
Site 95
S545
S
P
V
Y
S
N
S
S
V
R
N
E
L
P
M
Site 96
S556
E
L
P
M
H
H
N
S
S
R
K
S
T
K
K
Site 97
S560
H
H
N
S
S
R
K
S
T
K
K
T
N
Q
S
Site 98
T561
H
N
S
S
R
K
S
T
K
K
T
N
Q
S
S
Site 99
T564
S
R
K
S
T
K
K
T
N
Q
S
S
K
N
I
Site 100
T575
S
K
N
I
R
K
K
T
I
P
L
K
R
Q
K
Site 101
T583
I
P
L
K
R
Q
K
T
A
T
K
G
N
Q
R
Site 102
T585
L
K
R
Q
K
T
A
T
K
G
N
Q
R
V
Q
Site 103
S600
K
F
L
N
A
E
G
S
G
G
I
V
G
H
D
Site 104
S610
I
V
G
H
D
E
I
S
R
C
S
L
S
E
P
Site 105
S613
H
D
E
I
S
R
C
S
L
S
E
P
L
E
S
Site 106
S615
E
I
S
R
C
S
L
S
E
P
L
E
S
D
E
Site 107
S620
S
L
S
E
P
L
E
S
D
E
A
D
L
A
K
Site 108
S634
K
K
K
N
L
D
C
S
R
S
T
R
S
S
K
Site 109
S636
K
N
L
D
C
S
R
S
T
R
S
S
K
N
E
Site 110
T637
N
L
D
C
S
R
S
T
R
S
S
K
N
E
D
Site 111
S640
C
S
R
S
T
R
S
S
K
N
E
D
N
I
M
Site 112
Y661
L
K
P
Q
T
S
G
Y
T
C
N
I
P
T
E
Site 113
S669
T
C
N
I
P
T
E
S
N
L
D
S
G
E
H
Site 114
S673
P
T
E
S
N
L
D
S
G
E
H
K
T
S
V
Site 115
S679
D
S
G
E
H
K
T
S
V
L
E
E
S
G
P
Site 116
S684
K
T
S
V
L
E
E
S
G
P
S
R
L
N
N
Site 117
Y693
P
S
R
L
N
N
N
Y
L
M
S
G
K
N
D
Site 118
S709
D
D
E
E
V
H
G
S
S
D
D
S
K
Q
S
Site 119
S710
D
E
E
V
H
G
S
S
D
D
S
K
Q
S
K
Site 120
S713
V
H
G
S
S
D
D
S
K
Q
S
K
V
I
P
Site 121
S716
S
S
D
D
S
K
Q
S
K
V
I
P
K
N
R
Site 122
S732
H
H
K
L
V
L
P
S
N
T
P
N
V
R
R
Site 123
T734
K
L
V
L
P
S
N
T
P
N
V
R
R
T
K
Site 124
T740
N
T
P
N
V
R
R
T
K
R
T
R
L
K
P
Site 125
T743
N
V
R
R
T
K
R
T
R
L
K
P
L
E
Y
Site 126
Y750
T
R
L
K
P
L
E
Y
W
R
G
E
R
I
D
Site 127
Y758
W
R
G
E
R
I
D
Y
Q
G
R
P
S
G
G
Site 128
S763
I
D
Y
Q
G
R
P
S
G
G
F
V
I
S
G
Site 129
S773
F
V
I
S
G
V
L
S
P
D
T
I
S
S
K
Site 130
T776
S
G
V
L
S
P
D
T
I
S
S
K
R
K
A
Site 131
S779
L
S
P
D
T
I
S
S
K
R
K
A
K
E
N
Site 132
S794
I
G
K
V
N
K
K
S
N
K
K
R
I
C
L
Site 133
T808
L
D
N
D
E
R
K
T
N
L
M
V
N
L
G
Site 134
T825
L
G
D
P
L
Q
P
T
R
V
K
D
P
E
T
Site 135
T832
T
R
V
K
D
P
E
T
R
E
I
I
L
M
D
Site 136
Y847
L
V
R
P
Q
D
T
Y
Q
F
F
V
K
H
G
Site 137
Y859
K
H
G
E
L
K
V
Y
K
T
L
D
T
P
F
Site 138
T861
G
E
L
K
V
Y
K
T
L
D
T
P
F
F
S
Site 139
T864
K
V
Y
K
T
L
D
T
P
F
F
S
T
G
K
Site 140
Y908
C
T
L
H
E
T
P
Y
I
L
S
T
G
D
S
Site 141
S911
H
E
T
P
Y
I
L
S
T
G
D
S
F
Y
V
Site 142
S915
Y
I
L
S
T
G
D
S
F
Y
V
P
S
G
N
Site 143
Y917
L
S
T
G
D
S
F
Y
V
P
S
G
N
Y
Y
Site 144
Y924
Y
V
P
S
G
N
Y
Y
N
I
K
N
L
R
N
Site 145
S934
K
N
L
R
N
E
E
S
V
L
L
F
T
Q
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation