KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CREM
Full Name:
cAMP-responsive element modulator
Alias:
cAMP-responsive element modulator; cAMP-responsive element modulator, alpha isoform; CREM-alpha
Type:
Nucleus protein
Mass (Da):
37006
Number AA:
345
UniProt ID:
Q03060
International Prot ID:
IPI00337311
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008140
GO:0046983
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007275
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
S
K
C
A
R
K
K
Y
I
K
T
N
P
R
Q
Site 2
T12
A
R
K
K
Y
I
K
T
N
P
R
Q
M
T
M
Site 3
T18
K
T
N
P
R
Q
M
T
M
E
T
V
E
S
Q
Site 4
T21
P
R
Q
M
T
M
E
T
V
E
S
Q
H
D
G
Site 5
S24
M
T
M
E
T
V
E
S
Q
H
D
G
S
I
T
Site 6
S29
V
E
S
Q
H
D
G
S
I
T
A
S
L
T
E
Site 7
T31
S
Q
H
D
G
S
I
T
A
S
L
T
E
S
K
Site 8
S33
H
D
G
S
I
T
A
S
L
T
E
S
K
S
A
Site 9
T35
G
S
I
T
A
S
L
T
E
S
K
S
A
H
V
Site 10
S37
I
T
A
S
L
T
E
S
K
S
A
H
V
Q
T
Site 11
S39
A
S
L
T
E
S
K
S
A
H
V
Q
T
Q
T
Site 12
S62
A
Q
V
S
V
A
G
S
G
T
R
R
G
S
P
Site 13
T64
V
S
V
A
G
S
G
T
R
R
G
S
P
A
V
Site 14
S68
G
S
G
T
R
R
G
S
P
A
V
T
L
V
Q
Site 15
T72
R
R
G
S
P
A
V
T
L
V
Q
L
P
S
G
Site 16
S78
V
T
L
V
Q
L
P
S
G
Q
T
I
H
V
Q
Site 17
T90
H
V
Q
G
V
I
Q
T
P
Q
P
W
V
I
Q
Site 18
S99
A
I
A
E
T
D
E
S
A
E
S
E
G
V
I
Site 19
S115
A
I
A
E
T
D
E
S
A
E
S
E
G
V
I
Site 20
S118
E
T
D
E
S
A
E
S
E
G
V
I
D
S
H
Site 21
S124
E
S
E
G
V
I
D
S
H
K
R
R
E
I
L
Site 22
S132
H
K
R
R
E
I
L
S
R
R
P
S
Y
R
K
Site 23
S136
E
I
L
S
R
R
P
S
Y
R
K
I
L
N
E
Site 24
Y137
I
L
S
R
R
P
S
Y
R
K
I
L
N
E
L
Site 25
S146
K
I
L
N
E
L
S
S
D
V
P
G
V
P
K
Site 26
S159
P
K
I
E
E
E
R
S
E
E
E
G
T
P
P
Site 27
T164
E
R
S
E
E
E
G
T
P
P
S
I
A
T
M
Site 28
S167
E
E
E
G
T
P
P
S
I
A
T
M
A
V
P
Site 29
Y178
M
A
V
P
T
S
I
Y
Q
T
S
T
G
Q
Y
Site 30
T180
V
P
T
S
I
Y
Q
T
S
T
G
Q
Y
I
A
Site 31
Y185
Y
Q
T
S
T
G
Q
Y
I
A
I
A
Q
G
G
Site 32
S197
Q
G
G
T
I
Q
I
S
N
P
G
S
D
G
V
Site 33
S201
I
Q
I
S
N
P
G
S
D
G
V
Q
G
L
Q
Site 34
T213
G
L
Q
A
L
T
M
T
N
S
G
A
P
P
P
Site 35
S215
Q
A
L
T
M
T
N
S
G
A
P
P
P
G
A
Site 36
Y227
P
G
A
T
I
V
Q
Y
A
A
Q
S
A
D
G
Site 37
T235
A
A
Q
S
A
D
G
T
Q
Q
F
F
V
P
G
Site 38
S243
Q
Q
F
F
V
P
G
S
Q
V
V
V
Q
D
E
Site 39
T252
V
V
V
Q
D
E
E
T
E
L
A
P
S
H
M
Site 40
S257
E
E
T
E
L
A
P
S
H
M
A
A
A
T
G
Site 41
Y269
A
T
G
D
M
P
T
Y
Q
I
R
A
P
T
A
Site 42
T275
T
Y
Q
I
R
A
P
T
A
A
L
P
Q
G
V
Site 43
S287
Q
G
V
V
M
A
A
S
P
G
S
L
H
S
P
Site 44
S290
V
M
A
A
S
P
G
S
L
H
S
P
Q
Q
L
Site 45
S293
A
S
P
G
S
L
H
S
P
Q
Q
L
A
E
E
Site 46
Y326
C
R
R
R
K
K
E
Y
V
K
C
L
E
S
R
Site 47
T350
K
L
I
E
E
L
E
T
L
K
D
I
C
S
P
Site 48
S356
E
T
L
K
D
I
C
S
P
K
T
D
Y
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation