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Updated November 2019
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Protein Info
Short Name:
AKAP12
Full Name:
A-kinase anchor protein 12
Alias:
A kinase (PRKA) anchor protein 12; AKA12; AKAP250; A-kinase anchor protein 250 kDa; Gravin; Myasthenia gravis autoantigen; Myasthenia gravis autoantigen gravin; RP11-351K16.7-001; SSeCKS
Type:
Adapter/scaffold, anchoring protein
Mass (Da):
191483
Number AA:
1782
UniProt ID:
Q02952
International Prot ID:
IPI00237884
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005938
GO:0005856
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051018
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0006605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
G
A
G
S
S
T
E
Q
R
S
P
E
Q
Site 2
S11
G
S
S
T
E
Q
R
S
P
E
Q
P
P
E
G
Site 3
S19
P
E
Q
P
P
E
G
S
S
T
P
A
E
P
E
Site 4
S20
E
Q
P
P
E
G
S
S
T
P
A
E
P
E
P
Site 5
T21
Q
P
P
E
G
S
S
T
P
A
E
P
E
P
S
Site 6
S28
T
P
A
E
P
E
P
S
G
G
G
P
S
A
E
Site 7
T40
S
A
E
A
A
P
D
T
T
A
D
P
A
I
A
Site 8
T53
I
A
A
S
D
P
A
T
K
L
L
Q
K
N
G
Site 9
S75
V
A
E
Q
D
E
L
S
L
Q
E
G
D
L
N
Site 10
S96
N
G
Q
G
A
L
N
S
Q
E
E
E
E
V
I
Site 11
T105
E
E
E
E
V
I
V
T
E
V
G
Q
R
D
S
Site 12
S112
T
E
V
G
Q
R
D
S
E
D
V
S
E
R
D
Site 13
S116
Q
R
D
S
E
D
V
S
E
R
D
S
D
K
E
Site 14
S120
E
D
V
S
E
R
D
S
D
K
E
M
A
T
K
Site 15
S128
D
K
E
M
A
T
K
S
A
V
V
H
D
I
T
Site 16
T135
S
A
V
V
H
D
I
T
D
D
G
Q
E
E
T
Site 17
T142
T
D
D
G
Q
E
E
T
P
E
I
I
E
Q
I
Site 18
S151
E
I
I
E
Q
I
P
S
S
E
S
N
L
E
E
Site 19
S152
I
I
E
Q
I
P
S
S
E
S
N
L
E
E
L
Site 20
S165
E
L
T
Q
P
T
E
S
Q
A
N
D
I
G
F
Site 21
T190
F
T
V
K
K
D
K
T
E
K
P
D
T
V
Q
Site 22
T195
D
K
T
E
K
P
D
T
V
Q
L
L
T
V
K
Site 23
T200
P
D
T
V
Q
L
L
T
V
K
K
D
E
G
E
Site 24
S219
A
G
D
H
K
D
P
S
L
G
A
G
E
A
A
Site 25
S227
L
G
A
G
E
A
A
S
K
E
S
E
P
K
Q
Site 26
S235
K
E
S
E
P
K
Q
S
T
E
K
P
E
E
T
Site 27
T242
S
T
E
K
P
E
E
T
L
K
R
E
Q
S
H
Site 28
S248
E
T
L
K
R
E
Q
S
H
A
E
I
S
P
P
Site 29
S253
E
Q
S
H
A
E
I
S
P
P
A
E
S
G
Q
Site 30
S278
E
K
Q
E
K
E
P
S
K
S
A
E
S
P
T
Site 31
S280
Q
E
K
E
P
S
K
S
A
E
S
P
T
S
P
Site 32
S283
E
P
S
K
S
A
E
S
P
T
S
P
V
T
S
Site 33
T285
S
K
S
A
E
S
P
T
S
P
V
T
S
E
T
Site 34
S286
K
S
A
E
S
P
T
S
P
V
T
S
E
T
G
Site 35
T289
E
S
P
T
S
P
V
T
S
E
T
G
S
T
F
Site 36
S290
S
P
T
S
P
V
T
S
E
T
G
S
T
F
K
Site 37
S294
P
V
T
S
E
T
G
S
T
F
K
K
F
F
T
Site 38
T295
V
T
S
E
T
G
S
T
F
K
K
F
F
T
Q
Site 39
T311
W
A
G
W
R
K
K
T
S
F
R
K
P
K
E
Site 40
S312
A
G
W
R
K
K
T
S
F
R
K
P
K
E
D
Site 41
S324
K
E
D
E
V
E
A
S
E
K
K
K
E
Q
E
Site 42
T337
Q
E
P
E
K
V
D
T
E
E
D
G
K
A
E
Site 43
T351
E
V
A
S
E
K
L
T
A
S
E
Q
A
H
P
Site 44
S353
A
S
E
K
L
T
A
S
E
Q
A
H
P
Q
E
Site 45
S364
H
P
Q
E
P
A
E
S
A
H
E
P
R
L
S
Site 46
S371
S
A
H
E
P
R
L
S
A
E
Y
E
K
V
E
Site 47
Y374
E
P
R
L
S
A
E
Y
E
K
V
E
L
P
S
Site 48
S381
Y
E
K
V
E
L
P
S
E
E
Q
V
S
G
S
Site 49
S386
L
P
S
E
E
Q
V
S
G
S
Q
G
P
S
E
Site 50
S388
S
E
E
Q
V
S
G
S
Q
G
P
S
E
E
K
Site 51
S392
V
S
G
S
Q
G
P
S
E
E
K
P
A
P
L
Site 52
S422
V
V
A
E
V
H
V
S
T
V
E
E
R
T
E
Site 53
T433
E
R
T
E
E
Q
K
T
E
V
E
E
T
A
G
Site 54
T438
Q
K
T
E
V
E
E
T
A
G
S
V
P
A
E
Site 55
S441
E
V
E
E
T
A
G
S
V
P
A
E
E
L
V
Site 56
S472
K
L
K
E
T
C
V
S
G
E
D
P
T
Q
G
Site 57
T477
C
V
S
G
E
D
P
T
Q
G
A
D
L
S
P
Site 58
S483
P
T
Q
G
A
D
L
S
P
D
E
K
V
L
S
Site 59
S490
S
P
D
E
K
V
L
S
K
P
P
E
G
V
V
Site 60
S498
K
P
P
E
G
V
V
S
E
V
E
M
L
S
S
Site 61
S505
S
E
V
E
M
L
S
S
Q
E
R
M
K
V
Q
Site 62
S514
E
R
M
K
V
Q
G
S
P
L
K
K
L
F
T
Site 63
T521
S
P
L
K
K
L
F
T
S
T
G
L
K
K
L
Site 64
S522
P
L
K
K
L
F
T
S
T
G
L
K
K
L
S
Site 65
T523
L
K
K
L
F
T
S
T
G
L
K
K
L
S
G
Site 66
S529
S
T
G
L
K
K
L
S
G
K
K
Q
K
G
K
Site 67
S544
R
G
G
G
D
E
E
S
G
E
H
T
Q
V
P
Site 68
T548
D
E
E
S
G
E
H
T
Q
V
P
A
D
S
P
Site 69
S554
H
T
Q
V
P
A
D
S
P
D
S
Q
E
E
Q
Site 70
S557
V
P
A
D
S
P
D
S
Q
E
E
Q
K
G
E
Site 71
S565
Q
E
E
Q
K
G
E
S
S
A
S
S
P
E
E
Site 72
S566
E
E
Q
K
G
E
S
S
A
S
S
P
E
E
P
Site 73
S568
Q
K
G
E
S
S
A
S
S
P
E
E
P
E
E
Site 74
S569
K
G
E
S
S
A
S
S
P
E
E
P
E
E
I
Site 75
T597
G
E
A
E
E
G
A
T
S
D
G
E
K
K
R
Site 76
S598
E
A
E
E
G
A
T
S
D
G
E
K
K
R
E
Site 77
T608
E
K
K
R
E
G
V
T
P
W
A
S
F
K
K
Site 78
S612
E
G
V
T
P
W
A
S
F
K
K
M
V
T
P
Site 79
T618
A
S
F
K
K
M
V
T
P
K
K
R
V
R
R
Site 80
S627
K
K
R
V
R
R
P
S
E
S
D
K
E
D
E
Site 81
S629
R
V
R
R
P
S
E
S
D
K
E
D
E
L
D
Site 82
S640
D
E
L
D
K
V
K
S
A
T
L
S
S
T
E
Site 83
T642
L
D
K
V
K
S
A
T
L
S
S
T
E
S
T
Site 84
S644
K
V
K
S
A
T
L
S
S
T
E
S
T
A
S
Site 85
S645
V
K
S
A
T
L
S
S
T
E
S
T
A
S
E
Site 86
T646
K
S
A
T
L
S
S
T
E
S
T
A
S
E
M
Site 87
S648
A
T
L
S
S
T
E
S
T
A
S
E
M
Q
E
Site 88
T649
T
L
S
S
T
E
S
T
A
S
E
M
Q
E
E
Site 89
S651
S
S
T
E
S
T
A
S
E
M
Q
E
E
M
K
Site 90
S660
M
Q
E
E
M
K
G
S
V
E
E
P
K
P
E
Site 91
S676
P
K
R
K
V
D
T
S
V
S
W
E
A
L
I
Site 92
S687
E
A
L
I
C
V
G
S
S
K
K
R
A
R
R
Site 93
S696
K
K
R
A
R
R
G
S
S
S
D
E
E
G
G
Site 94
S697
K
R
A
R
R
G
S
S
S
D
E
E
G
G
P
Site 95
S698
R
A
R
R
G
S
S
S
D
E
E
G
G
P
K
Site 96
S732
T
D
G
I
L
A
G
S
Q
E
H
D
P
G
Q
Site 97
S741
E
H
D
P
G
Q
G
S
S
S
P
E
Q
A
G
Site 98
S742
H
D
P
G
Q
G
S
S
S
P
E
Q
A
G
S
Site 99
S743
D
P
G
Q
G
S
S
S
P
E
Q
A
G
S
P
Site 100
S749
S
S
P
E
Q
A
G
S
P
T
E
G
E
G
V
Site 101
T751
P
E
Q
A
G
S
P
T
E
G
E
G
V
S
T
Site 102
S757
P
T
E
G
E
G
V
S
T
W
E
S
F
K
R
Site 103
T758
T
E
G
E
G
V
S
T
W
E
S
F
K
R
L
Site 104
S761
E
G
V
S
T
W
E
S
F
K
R
L
V
T
P
Site 105
T767
E
S
F
K
R
L
V
T
P
R
K
K
S
K
S
Site 106
S772
L
V
T
P
R
K
K
S
K
S
K
L
E
E
K
Site 107
S774
T
P
R
K
K
S
K
S
K
L
E
E
K
S
E
Site 108
S780
K
S
K
L
E
E
K
S
E
D
S
I
A
G
S
Site 109
S783
L
E
E
K
S
E
D
S
I
A
G
S
G
V
E
Site 110
S787
S
E
D
S
I
A
G
S
G
V
E
H
S
T
P
Site 111
S792
A
G
S
G
V
E
H
S
T
P
D
T
E
P
G
Site 112
T793
G
S
G
V
E
H
S
T
P
D
T
E
P
G
K
Site 113
T796
V
E
H
S
T
P
D
T
E
P
G
K
E
E
S
Site 114
S803
T
E
P
G
K
E
E
S
W
V
S
I
K
K
F
Site 115
S806
G
K
E
E
S
W
V
S
I
K
K
F
I
P
G
Site 116
S841
T
G
A
N
E
D
D
S
D
V
P
A
V
V
P
Site 117
Y852
A
V
V
P
L
S
E
Y
D
A
V
E
R
E
K
Site 118
S868
E
A
Q
Q
A
Q
K
S
A
E
Q
P
E
Q
K
Site 119
S881
Q
K
A
A
T
E
V
S
K
E
L
S
E
S
Q
Site 120
S885
T
E
V
S
K
E
L
S
E
S
Q
V
H
M
M
Site 121
S887
V
S
K
E
L
S
E
S
Q
V
H
M
M
A
A
Site 122
T904
A
D
G
T
R
A
A
T
I
I
E
E
R
S
P
Site 123
S910
A
T
I
I
E
E
R
S
P
S
W
I
S
A
S
Site 124
S912
I
I
E
E
R
S
P
S
W
I
S
A
S
V
T
Site 125
S915
E
R
S
P
S
W
I
S
A
S
V
T
E
P
L
Site 126
S917
S
P
S
W
I
S
A
S
V
T
E
P
L
E
Q
Site 127
T919
S
W
I
S
A
S
V
T
E
P
L
E
Q
V
E
Site 128
T949
I
A
E
E
E
P
P
T
V
T
E
P
L
P
E
Site 129
T964
N
R
E
A
R
G
D
T
V
V
S
E
A
E
L
Site 130
T1010
V
S
A
V
S
Q
L
T
D
S
P
D
T
T
E
Site 131
S1012
A
V
S
Q
L
T
D
S
P
D
T
T
E
E
A
Site 132
T1016
L
T
D
S
P
D
T
T
E
E
A
T
P
V
Q
Site 133
T1020
P
D
T
T
E
E
A
T
P
V
Q
E
V
E
G
Site 134
T1039
I
E
E
Q
E
R
R
T
Q
E
V
L
Q
A
V
Site 135
S1054
A
E
K
V
K
E
E
S
Q
L
P
G
T
G
G
Site 136
T1059
E
E
S
Q
L
P
G
T
G
G
P
E
D
V
L
Site 137
T1116
G
K
V
V
G
Q
T
T
P
E
S
F
E
K
A
Site 138
S1119
V
G
Q
T
T
P
E
S
F
E
K
A
P
Q
V
Site 139
S1129
K
A
P
Q
V
T
E
S
I
E
S
S
E
L
V
Site 140
S1133
V
T
E
S
I
E
S
S
E
L
V
T
T
C
Q
Site 141
T1138
E
S
S
E
L
V
T
T
C
Q
A
E
T
L
A
Site 142
S1149
E
T
L
A
G
V
K
S
Q
E
M
V
M
E
Q
Site 143
S1162
E
Q
A
I
P
P
D
S
V
E
T
P
T
D
S
Site 144
T1165
I
P
P
D
S
V
E
T
P
T
D
S
E
T
D
Site 145
S1169
S
V
E
T
P
T
D
S
E
T
D
G
S
T
P
Site 146
T1171
E
T
P
T
D
S
E
T
D
G
S
T
P
V
A
Site 147
S1174
T
D
S
E
T
D
G
S
T
P
V
A
D
F
D
Site 148
T1175
D
S
E
T
D
G
S
T
P
V
A
D
F
D
A
Site 149
S1202
H
E
E
N
E
V
A
S
G
T
Q
S
G
G
T
Site 150
S1206
E
V
A
S
G
T
Q
S
G
G
T
E
A
E
A
Site 151
S1225
K
E
R
P
P
A
P
S
S
F
V
F
Q
E
E
Site 152
S1226
E
R
P
P
A
P
S
S
F
V
F
Q
E
E
T
Site 153
T1242
E
Q
S
K
M
E
D
T
L
E
H
T
D
K
E
Site 154
S1251
E
H
T
D
K
E
V
S
V
E
T
V
S
I
L
Site 155
T1254
D
K
E
V
S
V
E
T
V
S
I
L
S
K
T
Site 156
T1264
I
L
S
K
T
E
G
T
Q
E
A
D
Q
Y
A
Site 157
Y1270
G
T
Q
E
A
D
Q
Y
A
D
E
K
T
K
D
Site 158
T1275
D
Q
Y
A
D
E
K
T
K
D
V
P
F
F
E
Site 159
T1293
G
S
I
D
T
G
I
T
V
S
R
E
K
V
T
Site 160
S1295
I
D
T
G
I
T
V
S
R
E
K
V
T
E
V
Site 161
S1324
D
D
A
L
E
L
Q
S
H
A
K
S
P
P
S
Site 162
S1328
E
L
Q
S
H
A
K
S
P
P
S
P
V
E
R
Site 163
S1331
S
H
A
K
S
P
P
S
P
V
E
R
E
M
V
Site 164
T1346
V
Q
V
E
R
E
K
T
E
A
E
P
T
H
V
Site 165
T1351
E
K
T
E
A
E
P
T
H
V
N
E
E
K
L
Site 166
T1365
L
E
H
E
T
A
V
T
V
S
E
E
V
S
K
Site 167
S1367
H
E
T
A
V
T
V
S
E
E
V
S
K
Q
L
Site 168
S1390
I
D
G
A
K
E
V
S
S
L
E
G
S
P
P
Site 169
S1391
D
G
A
K
E
V
S
S
L
E
G
S
P
P
P
Site 170
S1395
E
V
S
S
L
E
G
S
P
P
P
C
L
G
Q
Site 171
T1408
G
Q
E
E
A
V
C
T
K
I
Q
V
Q
S
S
Site 172
S1415
T
K
I
Q
V
Q
S
S
E
A
S
F
T
L
T
Site 173
T1420
Q
S
S
E
A
S
F
T
L
T
A
A
A
E
E
Site 174
T1422
S
E
A
S
F
T
L
T
A
A
A
E
E
E
K
Site 175
T1443
N
I
L
E
T
G
E
T
L
E
P
A
G
A
H
Site 176
S1458
L
V
L
E
E
K
S
S
E
K
N
E
D
F
A
Site 177
T1484
P
D
C
Q
A
K
S
T
P
V
I
V
S
A
T
Site 178
S1498
T
T
K
K
G
L
S
S
D
L
E
G
E
K
T
Site 179
T1505
S
D
L
E
G
E
K
T
T
S
L
K
W
K
S
Site 180
S1507
L
E
G
E
K
T
T
S
L
K
W
K
S
D
E
Site 181
S1512
T
T
S
L
K
W
K
S
D
E
V
D
E
Q
V
Site 182
S1547
L
E
L
E
T
K
S
S
K
L
V
Q
N
I
I
Site 183
T1564
A
V
D
Q
F
V
R
T
E
E
T
A
T
E
M
Site 184
T1569
V
R
T
E
E
T
A
T
E
M
L
T
S
E
L
Site 185
S1587
A
H
V
I
K
A
D
S
Q
D
A
G
Q
E
T
Site 186
S1604
E
G
E
E
P
Q
A
S
A
Q
D
E
T
P
I
Site 187
T1609
Q
A
S
A
Q
D
E
T
P
I
T
S
A
K
E
Site 188
T1612
A
Q
D
E
T
P
I
T
S
A
K
E
E
S
E
Site 189
S1620
S
A
K
E
E
S
E
S
T
A
V
G
Q
A
H
Site 190
T1621
A
K
E
E
S
E
S
T
A
V
G
Q
A
H
S
Site 191
S1628
T
A
V
G
Q
A
H
S
D
I
S
K
D
M
S
Site 192
S1631
G
Q
A
H
S
D
I
S
K
D
M
S
E
A
S
Site 193
S1635
S
D
I
S
K
D
M
S
E
A
S
E
K
T
M
Site 194
T1643
E
A
S
E
K
T
M
T
V
E
V
E
G
S
T
Site 195
S1649
M
T
V
E
V
E
G
S
T
V
N
D
Q
Q
L
Site 196
S1663
L
E
E
V
V
L
P
S
E
E
E
G
G
G
A
Site 197
S1674
G
G
G
A
G
T
K
S
V
P
E
D
D
G
H
Site 198
S1691
L
A
E
R
I
E
K
S
L
V
E
P
K
E
D
Site 199
T1717
Q
N
S
A
L
A
D
T
D
A
S
G
G
L
T
Site 200
T1724
T
D
A
S
G
G
L
T
K
E
S
P
D
T
N
Site 201
S1727
S
G
G
L
T
K
E
S
P
D
T
N
G
P
K
Site 202
T1730
L
T
K
E
S
P
D
T
N
G
P
K
Q
K
E
Site 203
S1753
L
Q
E
G
K
V
H
S
E
S
D
K
A
I
T
Site 204
S1755
E
G
K
V
H
S
E
S
D
K
A
I
T
P
Q
Site 205
T1760
S
E
S
D
K
A
I
T
P
Q
A
Q
E
E
L
Site 206
S1774
L
Q
K
Q
E
R
E
S
A
K
S
E
L
T
E
Site 207
S1777
Q
E
R
E
S
A
K
S
E
L
T
E
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation