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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GUCY1A3
Full Name:
Guanylate cyclase soluble subunit alpha-3
Alias:
GC-SA3; GCS-alpha-1; GCS-alpha-3; GCYA3; Guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble, alpha-3 chain; Guanylate cyclase, soluble, alpha 1; GUC1A3; GUCSA3; GUCY1A1; Soluble guanylate cyclase large subunit
Type:
EC 4.6.1.2; Lyase; Nucleotide Metabolism - purine; Receptor, misc.; Guanylyl cyclase
Mass (Da):
77452
Number AA:
690
UniProt ID:
Q02108
International Prot ID:
IPI00024422
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008074
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0004383
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0006182
GO:0007263
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
P
G
Q
V
P
N
E
S
S
E
E
A
A
G
S
Site 2
S36
S
S
E
E
A
A
G
S
S
E
S
C
K
A
T
Site 3
S37
S
E
E
A
A
G
S
S
E
S
C
K
A
T
V
Site 4
T43
S
S
E
S
C
K
A
T
V
P
I
C
Q
D
I
Site 5
T64
E
S
L
P
Q
R
K
T
S
R
S
R
V
Y
L
Site 6
S65
S
L
P
Q
R
K
T
S
R
S
R
V
Y
L
H
Site 7
S67
P
Q
R
K
T
S
R
S
R
V
Y
L
H
T
L
Site 8
Y70
K
T
S
R
S
R
V
Y
L
H
T
L
A
E
S
Site 9
T73
R
S
R
V
Y
L
H
T
L
A
E
S
I
C
K
Site 10
S77
Y
L
H
T
L
A
E
S
I
C
K
L
I
F
P
Site 11
S108
K
I
K
E
S
R
K
S
L
E
R
E
D
F
E
Site 12
S135
P
V
E
V
I
K
E
S
L
G
E
E
V
F
K
Site 13
Y145
E
E
V
F
K
I
C
Y
E
E
D
E
N
I
L
Site 14
S165
T
L
K
D
F
L
N
S
F
S
T
L
L
K
Q
Site 15
S167
K
D
F
L
N
S
F
S
T
L
L
K
Q
S
S
Site 16
T168
D
F
L
N
S
F
S
T
L
L
K
Q
S
S
H
Site 17
S173
F
S
T
L
L
K
Q
S
S
H
C
Q
E
A
G
Site 18
S174
S
T
L
L
K
Q
S
S
H
C
Q
E
A
G
K
Site 19
S189
R
G
R
L
E
D
A
S
I
L
C
L
D
K
E
Site 20
Y203
E
D
D
F
L
H
V
Y
Y
F
F
P
K
R
T
Site 21
Y204
D
D
F
L
H
V
Y
Y
F
F
P
K
R
T
T
Site 22
Y252
S
E
F
V
N
Q
P
Y
L
L
Y
S
V
H
M
Site 23
S256
N
Q
P
Y
L
L
Y
S
V
H
M
K
S
T
K
Site 24
S261
L
Y
S
V
H
M
K
S
T
K
P
S
L
S
P
Site 25
S265
H
M
K
S
T
K
P
S
L
S
P
S
K
P
Q
Site 26
S267
K
S
T
K
P
S
L
S
P
S
K
P
Q
S
S
Site 27
S269
T
K
P
S
L
S
P
S
K
P
Q
S
S
L
V
Site 28
S273
L
S
P
S
K
P
Q
S
S
L
V
I
P
T
S
Site 29
S274
S
P
S
K
P
Q
S
S
L
V
I
P
T
S
L
Site 30
Y323
G
K
P
N
F
E
E
Y
F
E
I
L
T
P
K
Site 31
T328
E
E
Y
F
E
I
L
T
P
K
I
N
Q
T
F
Site 32
S356
R
V
R
R
W
D
N
S
V
K
K
S
S
R
V
Site 33
S360
W
D
N
S
V
K
K
S
S
R
V
M
D
L
K
Site 34
T394
V
D
R
L
E
D
F
T
G
R
G
L
Y
L
S
Site 35
Y399
D
F
T
G
R
G
L
Y
L
S
D
I
P
I
H
Site 36
S401
T
G
R
G
L
Y
L
S
D
I
P
I
H
N
A
Site 37
T450
L
E
E
E
K
K
K
T
V
D
L
L
C
S
I
Site 38
Y510
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
Site 39
Y523
Q
C
G
E
L
D
V
Y
K
V
E
T
I
G
D
Site 40
T544
G
L
H
K
E
S
D
T
H
A
V
Q
I
A
L
Site 41
S560
A
L
K
M
M
E
L
S
D
E
V
M
S
P
H
Site 42
S565
E
L
S
D
E
V
M
S
P
H
G
E
P
I
K
Site 43
S611
A
N
K
F
E
S
C
S
V
P
R
K
I
N
V
Site 44
S619
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
Site 45
T621
R
K
I
N
V
S
P
T
T
Y
R
L
L
K
D
Site 46
T622
K
I
N
V
S
P
T
T
Y
R
L
L
K
D
C
Site 47
Y623
I
N
V
S
P
T
T
Y
R
L
L
K
D
C
P
Site 48
T635
D
C
P
G
F
V
F
T
P
R
S
R
E
E
L
Site 49
S638
G
F
V
F
T
P
R
S
R
E
E
L
P
P
N
Site 50
S648
E
L
P
P
N
F
P
S
E
I
P
G
I
C
H
Site 51
Y660
I
C
H
F
L
D
A
Y
Q
Q
G
T
N
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation