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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCB3
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3
Alias:
1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta 3; EC 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C, beta 3 (phosphatidylinositol-specific); Phospholipase C-beta-3; PLC-beta3; PLC-beta-3
Type:
Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase
Mass (Da):
138799
Number AA:
1234
UniProt ID:
Q01970
International Prot ID:
IPI00010400
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
A
L
Q
L
E
P
P
T
V
V
E
T
L
R
R
Site 2
T21
E
P
P
T
V
V
E
T
L
R
R
G
S
K
F
Site 3
S26
V
E
T
L
R
R
G
S
K
F
I
K
W
D
E
Site 4
T35
F
I
K
W
D
E
E
T
S
S
R
N
L
V
T
Site 5
S36
I
K
W
D
E
E
T
S
S
R
N
L
V
T
L
Site 6
S37
K
W
D
E
E
T
S
S
R
N
L
V
T
L
R
Site 7
T42
T
S
S
R
N
L
V
T
L
R
V
D
P
N
G
Site 8
Y53
D
P
N
G
F
F
L
Y
W
T
G
P
N
M
E
Site 9
T63
G
P
N
M
E
V
D
T
L
D
I
S
S
I
R
Site 10
S68
V
D
T
L
D
I
S
S
I
R
D
T
R
T
G
Site 11
T72
D
I
S
S
I
R
D
T
R
T
G
R
Y
A
R
Site 12
T74
S
S
I
R
D
T
R
T
G
R
Y
A
R
L
P
Site 13
T105
R
L
E
E
K
L
M
T
V
V
S
G
P
D
P
Site 14
S108
E
K
L
M
T
V
V
S
G
P
D
P
V
N
T
Site 15
T127
F
M
A
V
Q
D
D
T
A
K
V
W
S
E
E
Site 16
S148
N
I
L
A
Q
N
A
S
R
N
T
F
L
R
K
Site 17
T151
A
Q
N
A
S
R
N
T
F
L
R
K
A
Y
T
Site 18
Y157
N
T
F
L
R
K
A
Y
T
K
L
K
L
Q
V
Site 19
T188
A
D
K
K
R
V
E
T
A
L
E
S
C
G
L
Site 20
S200
C
G
L
K
F
N
R
S
E
S
I
R
P
D
E
Site 21
S202
L
K
F
N
R
S
E
S
I
R
P
D
E
F
S
Site 22
S209
S
I
R
P
D
E
F
S
L
E
I
F
E
R
F
Site 23
Y240
I
G
A
K
G
K
P
Y
L
T
L
E
Q
L
M
Site 24
T242
A
K
G
K
P
Y
L
T
L
E
Q
L
M
D
F
Site 25
Y264
P
R
L
N
E
V
L
Y
P
P
L
R
P
S
Q
Site 26
S270
L
Y
P
P
L
R
P
S
Q
A
R
L
L
I
E
Site 27
Y279
A
R
L
L
I
E
K
Y
E
P
N
Q
Q
F
L
Site 28
S292
F
L
E
R
D
Q
M
S
M
E
G
F
S
R
Y
Site 29
Y299
S
M
E
G
F
S
R
Y
L
G
G
E
E
N
G
Site 30
S316
P
L
E
A
L
D
L
S
T
D
M
T
Q
P
L
Site 31
T317
L
E
A
L
D
L
S
T
D
M
T
Q
P
L
S
Site 32
T320
L
D
L
S
T
D
M
T
Q
P
L
S
A
Y
F
Site 33
S324
T
D
M
T
Q
P
L
S
A
Y
F
I
N
S
S
Site 34
Y326
M
T
Q
P
L
S
A
Y
F
I
N
S
S
H
N
Site 35
T334
F
I
N
S
S
H
N
T
Y
L
T
A
G
Q
L
Site 36
Y335
I
N
S
S
H
N
T
Y
L
T
A
G
Q
L
A
Site 37
T337
S
S
H
N
T
Y
L
T
A
G
Q
L
A
G
T
Site 38
S346
G
Q
L
A
G
T
S
S
V
E
M
Y
R
Q
A
Site 39
Y350
G
T
S
S
V
E
M
Y
R
Q
A
L
L
W
G
Site 40
T378
P
E
E
E
P
F
I
T
H
G
F
T
M
T
T
Site 41
T385
T
H
G
F
T
M
T
T
E
V
P
L
R
D
V
Site 42
S411
S
P
Y
P
V
I
L
S
F
E
N
H
V
D
S
Site 43
S418
S
F
E
N
H
V
D
S
A
K
Q
Q
A
K
M
Site 44
Y428
Q
Q
A
K
M
A
E
Y
C
R
S
I
F
G
D
Site 45
S455
A
P
G
V
P
L
P
S
P
Q
D
L
M
G
R
Site 46
S474
N
K
K
R
H
R
P
S
A
G
G
P
D
S
A
Site 47
S480
P
S
A
G
G
P
D
S
A
G
R
K
R
P
L
Site 48
S490
R
K
R
P
L
E
Q
S
N
S
A
L
S
E
S
Site 49
S492
R
P
L
E
Q
S
N
S
A
L
S
E
S
S
A
Site 50
S495
E
Q
S
N
S
A
L
S
E
S
S
A
A
T
E
Site 51
S497
S
N
S
A
L
S
E
S
S
A
A
T
E
P
S
Site 52
S498
N
S
A
L
S
E
S
S
A
A
T
E
P
S
S
Site 53
T501
L
S
E
S
S
A
A
T
E
P
S
S
P
Q
L
Site 54
S504
S
S
A
A
T
E
P
S
S
P
Q
L
G
S
P
Site 55
S505
S
A
A
T
E
P
S
S
P
Q
L
G
S
P
S
Site 56
S510
P
S
S
P
Q
L
G
S
P
S
S
D
S
C
P
Site 57
S512
S
P
Q
L
G
S
P
S
S
D
S
C
P
G
L
Site 58
S513
P
Q
L
G
S
P
S
S
D
S
C
P
G
L
S
Site 59
S515
L
G
S
P
S
S
D
S
C
P
G
L
S
N
G
Site 60
S520
S
D
S
C
P
G
L
S
N
G
E
E
V
G
L
Site 61
S531
E
V
G
L
E
K
P
S
L
E
P
Q
K
S
L
Site 62
S537
P
S
L
E
P
Q
K
S
L
G
D
E
G
L
N
Site 63
Y548
E
G
L
N
R
G
P
Y
V
L
G
P
A
D
R
Site 64
T568
D
E
E
E
E
E
Q
T
D
P
K
K
P
T
T
Site 65
T575
T
D
P
K
K
P
T
T
D
E
G
T
A
S
S
Site 66
S581
T
T
D
E
G
T
A
S
S
E
V
N
A
T
E
Site 67
T587
A
S
S
E
V
N
A
T
E
E
M
S
T
L
V
Site 68
T592
N
A
T
E
E
M
S
T
L
V
N
Y
I
E
P
Site 69
Y596
E
M
S
T
L
V
N
Y
I
E
P
V
K
F
K
Site 70
S604
I
E
P
V
K
F
K
S
F
E
A
A
R
K
R
Site 71
T623
E
M
S
S
F
V
E
T
K
A
M
E
Q
L
T
Site 72
T630
T
K
A
M
E
Q
L
T
K
S
P
M
E
F
V
Site 73
S632
A
M
E
Q
L
T
K
S
P
M
E
F
V
E
Y
Site 74
Y639
S
P
M
E
F
V
E
Y
N
K
Q
Q
L
S
R
Site 75
S645
E
Y
N
K
Q
Q
L
S
R
I
Y
P
K
G
T
Site 76
Y648
K
Q
Q
L
S
R
I
Y
P
K
G
T
R
V
D
Site 77
T652
S
R
I
Y
P
K
G
T
R
V
D
S
S
N
Y
Site 78
S656
P
K
G
T
R
V
D
S
S
N
Y
M
P
Q
L
Site 79
S657
K
G
T
R
V
D
S
S
N
Y
M
P
Q
L
F
Site 80
Y692
L
N
A
G
V
F
E
Y
N
G
R
S
G
Y
L
Site 81
Y698
E
Y
N
G
R
S
G
Y
L
L
K
P
E
F
M
Site 82
S711
F
M
R
R
P
D
K
S
F
D
P
F
T
E
V
Site 83
Y746
S
D
R
K
V
G
I
Y
V
E
V
D
M
F
G
Site 84
T758
M
F
G
L
P
V
D
T
R
R
K
Y
R
T
R
Site 85
Y762
P
V
D
T
R
R
K
Y
R
T
R
T
S
Q
G
Site 86
T764
D
T
R
R
K
Y
R
T
R
T
S
Q
G
N
S
Site 87
T766
R
R
K
Y
R
T
R
T
S
Q
G
N
S
F
N
Site 88
S767
R
K
Y
R
T
R
T
S
Q
G
N
S
F
N
P
Site 89
S771
T
R
T
S
Q
G
N
S
F
N
P
V
W
D
E
Site 90
S814
G
H
R
I
L
P
V
S
A
I
R
S
G
Y
H
Site 91
Y820
V
S
A
I
R
S
G
Y
H
Y
V
C
L
R
N
Site 92
Y822
A
I
R
S
G
Y
H
Y
V
C
L
R
N
E
A
Site 93
Y847
I
Y
T
E
A
S
D
Y
I
P
D
D
H
Q
D
Site 94
Y855
I
P
D
D
H
Q
D
Y
A
E
A
L
I
N
P
Site 95
S867
I
N
P
I
K
H
V
S
L
M
D
Q
R
A
R
Site 96
T895
G
Q
E
T
C
Q
D
T
Q
S
Q
Q
L
G
S
Site 97
S897
E
T
C
Q
D
T
Q
S
Q
Q
L
G
S
Q
P
Site 98
S902
T
Q
S
Q
Q
L
G
S
Q
P
S
S
N
P
T
Site 99
S905
Q
Q
L
G
S
Q
P
S
S
N
P
T
P
S
P
Site 100
S906
Q
L
G
S
Q
P
S
S
N
P
T
P
S
P
L
Site 101
T909
S
Q
P
S
S
N
P
T
P
S
P
L
D
A
S
Site 102
S911
P
S
S
N
P
T
P
S
P
L
D
A
S
P
R
Site 103
S916
T
P
S
P
L
D
A
S
P
R
R
P
P
G
P
Site 104
T924
P
R
R
P
P
G
P
T
T
S
P
A
S
T
S
Site 105
T925
R
R
P
P
G
P
T
T
S
P
A
S
T
S
L
Site 106
S926
R
P
P
G
P
T
T
S
P
A
S
T
S
L
S
Site 107
S929
G
P
T
T
S
P
A
S
T
S
L
S
S
P
G
Site 108
T930
P
T
T
S
P
A
S
T
S
L
S
S
P
G
Q
Site 109
S931
T
T
S
P
A
S
T
S
L
S
S
P
G
Q
R
Site 110
S933
S
P
A
S
T
S
L
S
S
P
G
Q
R
D
D
Site 111
S934
P
A
S
T
S
L
S
S
P
G
Q
R
D
D
L
Site 112
T987
K
H
Q
R
K
A
V
T
L
T
R
R
L
L
D
Site 113
Y1031
G
E
D
E
A
K
R
Y
Q
E
F
Q
N
R
Q
Site 114
S1105
L
D
R
K
R
H
N
S
I
S
E
A
K
M
R
Site 115
S1107
R
K
R
H
N
S
I
S
E
A
K
M
R
D
K
Site 116
T1122
H
K
K
E
A
E
L
T
E
I
N
R
R
H
I
Site 117
T1130
E
I
N
R
R
H
I
T
E
S
V
N
S
I
R
Site 118
S1132
N
R
R
H
I
T
E
S
V
N
S
I
R
R
L
Site 119
S1135
H
I
T
E
S
V
N
S
I
R
R
L
E
E
A
Site 120
S1190
L
P
Q
E
I
R
R
S
L
L
G
E
M
P
E
Site 121
S1216
S
N
G
H
A
P
G
S
S
G
H
L
S
G
A
Site 122
S1217
N
G
H
A
P
G
S
S
G
H
L
S
G
A
D
Site 123
S1221
P
G
S
S
G
H
L
S
G
A
D
S
E
S
Q
Site 124
S1225
G
H
L
S
G
A
D
S
E
S
Q
E
E
N
T
Site 125
S1227
L
S
G
A
D
S
E
S
Q
E
E
N
T
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation