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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CACNA1D
Full Name:
Voltage-dependent L-type calcium channel subunit alpha-1D
Alias:
CAC1D; CACH3; CACN4; CACNL1A2; Calcium channel, L type, alpha-1 polypeptide, isoform 2; Calcium channel, voltage-dependent, L type, alpha 1D subunit; Cav1.3; CCHL1A2; Voltage-dependent L-type calcium channel alpha-1D; Voltage-gated calcium channel alpha Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3
Type:
Channel protein, calcium
Mass (Da):
245141
Number AA:
2161
UniProt ID:
Q01668
International Prot ID:
IPI00009008
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005891
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0015270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Voltage-dependent L-type calcium channel subunit alpha-1D pan-specific antibody AB-NN226-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN226-1#Inositol polyphosphate 5-phosphatase OCRL-1 pan-specific antibody AB-NN271-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN271-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
D
H
A
N
E
A
N
Y
A
R
G
T
R
L
P
Site 2
T30
E
A
N
Y
A
R
G
T
R
L
P
L
S
G
E
Site 3
S35
R
G
T
R
L
P
L
S
G
E
G
P
T
S
Q
Site 4
T40
P
L
S
G
E
G
P
T
S
Q
P
N
S
S
K
Site 5
S41
L
S
G
E
G
P
T
S
Q
P
N
S
S
K
Q
Site 6
S45
G
P
T
S
Q
P
N
S
S
K
Q
T
V
L
S
Site 7
S46
P
T
S
Q
P
N
S
S
K
Q
T
V
L
S
W
Site 8
T49
Q
P
N
S
S
K
Q
T
V
L
S
W
Q
A
A
Site 9
S52
S
S
K
Q
T
V
L
S
W
Q
A
A
I
D
A
Site 10
T68
R
Q
A
K
A
A
Q
T
M
S
T
S
A
P
P
Site 11
S70
A
K
A
A
Q
T
M
S
T
S
A
P
P
P
V
Site 12
T71
K
A
A
Q
T
M
S
T
S
A
P
P
P
V
G
Site 13
S72
A
A
Q
T
M
S
T
S
A
P
P
P
V
G
S
Site 14
S79
S
A
P
P
P
V
G
S
L
S
Q
R
K
R
Q
Site 15
S81
P
P
P
V
G
S
L
S
Q
R
K
R
Q
Q
Y
Site 16
Y88
S
Q
R
K
R
Q
Q
Y
A
K
S
K
K
Q
G
Site 17
S91
K
R
Q
Q
Y
A
K
S
K
K
Q
G
N
S
S
Site 18
S98
S
K
K
Q
G
N
S
S
N
S
R
P
A
R
A
Site 19
S121
P
I
R
R
A
C
I
S
I
V
E
W
K
P
F
Site 20
S154
I
P
F
P
E
D
D
S
N
S
T
N
H
N
L
Site 21
S156
F
P
E
D
D
S
N
S
T
N
H
N
L
E
K
Site 22
Y192
L
L
L
H
P
N
A
Y
V
R
N
G
W
N
L
Site 23
S227
E
T
E
G
G
N
H
S
S
G
K
S
G
G
F
Site 24
S228
T
E
G
G
N
H
S
S
G
K
S
G
G
F
D
Site 25
S231
G
N
H
S
S
G
K
S
G
G
F
D
V
K
A
Site 26
S306
K
T
C
F
F
A
D
S
D
I
V
A
E
E
D
Site 27
T327
S
G
N
G
R
Q
C
T
A
N
G
T
E
C
R
Site 28
S406
N
L
V
L
G
V
L
S
G
E
F
S
K
E
R
Site 29
S410
G
V
L
S
G
E
F
S
K
E
R
E
K
A
K
Site 30
Y438
L
E
E
D
L
K
G
Y
L
D
W
I
T
Q
A
Site 31
T443
K
G
Y
L
D
W
I
T
Q
A
E
D
I
D
P
Site 32
T464
G
E
E
G
K
R
N
T
S
M
P
T
S
E
T
Site 33
S465
E
E
G
K
R
N
T
S
M
P
T
S
E
T
E
Site 34
S469
R
N
T
S
M
P
T
S
E
T
E
S
V
N
T
Site 35
S473
M
P
T
S
E
T
E
S
V
N
T
E
N
V
S
Site 36
T476
S
E
T
E
S
V
N
T
E
N
V
S
G
E
G
Site 37
S480
S
V
N
T
E
N
V
S
G
E
G
E
N
R
G
Site 38
S491
E
N
R
G
C
C
G
S
L
C
Q
A
I
S
K
Site 39
S497
G
S
L
C
Q
A
I
S
K
S
K
L
S
R
R
Site 40
S499
L
C
Q
A
I
S
K
S
K
L
S
R
R
W
R
Site 41
S502
A
I
S
K
S
K
L
S
R
R
W
R
R
W
N
Site 42
Y545
L
T
I
S
S
E
H
Y
N
Q
P
D
W
L
T
Site 43
T634
F
K
V
T
R
H
W
T
S
L
S
N
L
V
A
Site 44
S635
K
V
T
R
H
W
T
S
L
S
N
L
V
A
S
Site 45
T681
G
K
F
N
F
D
E
T
Q
T
K
R
S
T
F
Site 46
T687
E
T
Q
T
K
R
S
T
F
D
N
F
P
Q
A
Site 47
Y712
E
D
W
N
A
V
M
Y
D
G
I
M
A
Y
G
Site 48
Y718
M
Y
D
G
I
M
A
Y
G
G
P
S
S
S
G
Site 49
S760
D
N
L
A
D
A
E
S
L
N
T
A
Q
K
E
Site 50
S782
K
K
I
A
R
K
E
S
L
E
N
K
K
N
N
Site 51
S799
E
V
N
Q
I
A
N
S
D
N
K
V
T
I
D
Site 52
T804
A
N
S
D
N
K
V
T
I
D
D
Y
R
E
E
Site 53
Y808
N
K
V
T
I
D
D
Y
R
E
E
D
E
D
K
Site 54
Y818
E
D
E
D
K
D
P
Y
P
P
C
D
V
P
V
Site 55
S849
G
P
R
P
R
R
I
S
E
L
N
M
K
E
K
Site 56
S864
I
A
P
I
P
E
G
S
A
F
F
I
L
S
K
Site 57
S870
G
S
A
F
F
I
L
S
K
T
N
P
I
R
V
Site 58
S913
E
D
P
I
R
S
H
S
F
R
N
T
I
L
G
Site 59
T917
R
S
H
S
F
R
N
T
I
L
G
Y
F
D
Y
Site 60
T1045
K
G
K
F
Y
R
C
T
D
E
A
K
S
N
P
Site 61
S1050
R
C
T
D
E
A
K
S
N
P
E
E
C
R
G
Site 62
S1069
Y
K
D
G
D
V
D
S
P
V
V
R
E
R
I
Site 63
Y1108
E
G
W
P
A
L
L
Y
K
A
I
D
S
N
G
Site 64
Y1122
G
E
N
I
G
P
I
Y
N
H
R
V
E
I
S
Site 65
Y1178
N
Q
R
Q
C
V
E
Y
A
L
K
A
R
P
L
Site 66
Y1188
K
A
R
P
L
R
R
Y
I
P
K
N
P
Y
Q
Site 67
Y1194
R
Y
I
P
K
N
P
Y
Q
Y
K
F
W
Y
V
Site 68
Y1200
P
Y
Q
Y
K
F
W
Y
V
V
N
S
S
P
F
Site 69
Y1227
L
C
L
A
M
Q
H
Y
E
Q
S
K
M
F
N
Site 70
Y1264
I
A
F
K
P
K
G
Y
F
S
D
A
W
N
T
Site 71
S1287
S
I
I
D
V
A
L
S
E
A
D
P
T
E
S
Site 72
T1292
A
L
S
E
A
D
P
T
E
S
E
N
V
P
V
Site 73
T1301
S
E
N
V
P
V
P
T
A
T
P
G
N
S
E
Site 74
T1303
N
V
P
V
P
T
A
T
P
G
N
S
E
E
S
Site 75
S1307
P
T
A
T
P
G
N
S
E
E
S
N
R
I
S
Site 76
S1310
T
P
G
N
S
E
E
S
N
R
I
S
I
T
F
Site 77
S1314
S
E
E
S
N
R
I
S
I
T
F
F
R
L
F
Site 78
S1331
M
R
L
V
K
L
L
S
R
G
E
G
I
R
T
Site 79
T1338
S
R
G
E
G
I
R
T
L
L
W
T
F
I
K
Site 80
S1425
G
K
L
C
D
P
E
S
D
Y
N
P
G
E
E
Site 81
Y1427
L
C
D
P
E
S
D
Y
N
P
G
E
E
Y
T
Site 82
Y1433
D
Y
N
P
G
E
E
Y
T
C
G
S
N
F
A
Site 83
Y1469
V
I
M
D
N
F
D
Y
L
T
R
D
W
S
I
Site 84
S1475
D
Y
L
T
R
D
W
S
I
L
G
P
H
H
L
Site 85
S1490
D
E
F
K
R
I
W
S
E
Y
D
P
E
A
K
Site 86
Y1492
F
K
R
I
W
S
E
Y
D
P
E
A
K
G
R
Site 87
S1540
A
M
N
M
P
L
N
S
D
G
T
V
M
F
N
Site 88
T1549
G
T
V
M
F
N
A
T
L
F
A
L
V
R
T
Site 89
T1602
P
A
G
D
D
E
V
T
V
G
K
F
Y
A
T
Site 90
Y1615
A
T
F
L
I
Q
D
Y
F
R
K
F
K
K
R
Site 91
Y1631
E
Q
G
L
V
G
K
Y
P
A
K
N
T
T
I
Site 92
S1659
P
E
I
R
R
A
I
S
C
D
L
Q
D
D
E
Site 93
T1670
Q
D
D
E
P
E
E
T
K
R
E
E
E
D
D
Site 94
S1695
N
H
V
N
H
V
N
S
D
R
R
D
S
L
Q
Site 95
S1700
V
N
S
D
R
R
D
S
L
Q
Q
T
N
T
T
Site 96
T1704
R
R
D
S
L
Q
Q
T
N
T
T
H
R
P
L
Site 97
T1706
D
S
L
Q
Q
T
N
T
T
H
R
P
L
H
V
Site 98
T1707
S
L
Q
Q
T
N
T
T
H
R
P
L
H
V
Q
Site 99
S1717
P
L
H
V
Q
R
P
S
I
P
P
A
S
D
T
Site 100
S1722
R
P
S
I
P
P
A
S
D
T
E
K
P
L
F
Site 101
T1724
S
I
P
P
A
S
D
T
E
K
P
L
F
P
P
Site 102
S1745
H
N
H
H
N
H
N
S
I
G
K
Q
V
P
T
Site 103
T1752
S
I
G
K
Q
V
P
T
S
T
N
A
N
L
N
Site 104
S1753
I
G
K
Q
V
P
T
S
T
N
A
N
L
N
N
Site 105
S1773
A
A
H
G
K
R
P
S
I
G
N
L
E
H
V
Site 106
S1788
S
E
N
G
H
H
S
S
H
K
H
D
R
E
P
Site 107
S1799
D
R
E
P
Q
R
R
S
S
V
K
R
T
R
Y
Site 108
S1800
R
E
P
Q
R
R
S
S
V
K
R
T
R
Y
Y
Site 109
T1804
R
R
S
S
V
K
R
T
R
Y
Y
E
T
Y
I
Site 110
Y1806
S
S
V
K
R
T
R
Y
Y
E
T
Y
I
R
S
Site 111
Y1807
S
V
K
R
T
R
Y
Y
E
T
Y
I
R
S
D
Site 112
T1809
K
R
T
R
Y
Y
E
T
Y
I
R
S
D
S
G
Site 113
Y1810
R
T
R
Y
Y
E
T
Y
I
R
S
D
S
G
D
Site 114
S1813
Y
Y
E
T
Y
I
R
S
D
S
G
D
E
Q
L
Site 115
S1815
E
T
Y
I
R
S
D
S
G
D
E
Q
L
P
T
Site 116
T1822
S
G
D
E
Q
L
P
T
I
C
R
E
D
P
E
Site 117
Y1833
E
D
P
E
I
H
G
Y
F
R
D
P
H
C
L
Site 118
Y1845
H
C
L
G
E
Q
E
Y
F
S
S
E
E
C
Y
Site 119
S1847
L
G
E
Q
E
Y
F
S
S
E
E
C
Y
E
D
Site 120
S1848
G
E
Q
E
Y
F
S
S
E
E
C
Y
E
D
D
Site 121
Y1852
Y
F
S
S
E
E
C
Y
E
D
D
S
S
P
T
Site 122
S1856
E
E
C
Y
E
D
D
S
S
P
T
W
S
R
Q
Site 123
S1857
E
C
Y
E
D
D
S
S
P
T
W
S
R
Q
N
Site 124
Y1865
P
T
W
S
R
Q
N
Y
G
Y
Y
S
R
Y
P
Site 125
Y1867
W
S
R
Q
N
Y
G
Y
Y
S
R
Y
P
G
R
Site 126
Y1868
S
R
Q
N
Y
G
Y
Y
S
R
Y
P
G
R
N
Site 127
Y1871
N
Y
G
Y
Y
S
R
Y
P
G
R
N
I
D
S
Site 128
S1878
Y
P
G
R
N
I
D
S
E
R
P
R
G
Y
H
Site 129
Y1884
D
S
E
R
P
R
G
Y
H
H
P
Q
G
F
L
Site 130
S1896
G
F
L
E
D
D
D
S
P
V
C
Y
D
S
R
Site 131
Y1900
D
D
D
S
P
V
C
Y
D
S
R
R
S
P
R
Site 132
S1902
D
S
P
V
C
Y
D
S
R
R
S
P
R
R
R
Site 133
S1905
V
C
Y
D
S
R
R
S
P
R
R
R
L
L
P
Site 134
T1914
R
R
R
L
L
P
P
T
P
A
S
H
R
R
S
Site 135
S1917
L
L
P
P
T
P
A
S
H
R
R
S
S
F
N
Site 136
S1921
T
P
A
S
H
R
R
S
S
F
N
F
E
C
L
Site 137
S1922
P
A
S
H
R
R
S
S
F
N
F
E
C
L
R
Site 138
S1932
F
E
C
L
R
R
Q
S
S
Q
E
E
V
P
S
Site 139
S1933
E
C
L
R
R
Q
S
S
Q
E
E
V
P
S
S
Site 140
S1939
S
S
Q
E
E
V
P
S
S
P
I
F
P
H
R
Site 141
S1940
S
Q
E
E
V
P
S
S
P
I
F
P
H
R
T
Site 142
S1966
M
A
V
A
G
L
D
S
S
K
A
Q
K
Y
S
Site 143
S1967
A
V
A
G
L
D
S
S
K
A
Q
K
Y
S
P
Site 144
S1973
S
S
K
A
Q
K
Y
S
P
S
H
S
T
R
S
Site 145
S1975
K
A
Q
K
Y
S
P
S
H
S
T
R
S
W
A
Site 146
S1977
Q
K
Y
S
P
S
H
S
T
R
S
W
A
T
P
Site 147
S1980
S
P
S
H
S
T
R
S
W
A
T
P
P
A
T
Site 148
T1983
H
S
T
R
S
W
A
T
P
P
A
T
P
P
Y
Site 149
T1987
S
W
A
T
P
P
A
T
P
P
Y
R
D
W
T
Site 150
Y1990
T
P
P
A
T
P
P
Y
R
D
W
T
P
C
Y
Site 151
T1994
T
P
P
Y
R
D
W
T
P
C
Y
T
P
L
I
Site 152
Y1997
Y
R
D
W
T
P
C
Y
T
P
L
I
Q
V
E
Site 153
T1998
R
D
W
T
P
C
Y
T
P
L
I
Q
V
E
Q
Site 154
S2006
P
L
I
Q
V
E
Q
S
E
A
L
D
Q
V
N
Site 155
S2015
A
L
D
Q
V
N
G
S
L
P
S
L
H
R
S
Site 156
S2018
Q
V
N
G
S
L
P
S
L
H
R
S
S
W
Y
Site 157
S2022
S
L
P
S
L
H
R
S
S
W
Y
T
D
E
P
Site 158
S2023
L
P
S
L
H
R
S
S
W
Y
T
D
E
P
D
Site 159
T2026
L
H
R
S
S
W
Y
T
D
E
P
D
I
S
Y
Site 160
S2032
Y
T
D
E
P
D
I
S
Y
R
T
F
T
P
A
Site 161
Y2033
T
D
E
P
D
I
S
Y
R
T
F
T
P
A
S
Site 162
T2035
E
P
D
I
S
Y
R
T
F
T
P
A
S
L
T
Site 163
T2037
D
I
S
Y
R
T
F
T
P
A
S
L
T
V
P
Site 164
S2040
Y
R
T
F
T
P
A
S
L
T
V
P
S
S
F
Site 165
T2042
T
F
T
P
A
S
L
T
V
P
S
S
F
R
N
Site 166
S2046
A
S
L
T
V
P
S
S
F
R
N
K
N
S
D
Site 167
S2060
D
K
Q
R
S
A
D
S
L
V
E
A
V
L
I
Site 168
Y2074
I
S
E
G
L
G
R
Y
A
R
D
P
K
F
V
Site 169
T2105
E
M
E
S
A
A
S
T
L
L
N
G
N
V
R
Site 170
S2123
N
G
D
V
G
P
L
S
H
R
Q
D
Y
E
L
Site 171
Y2128
P
L
S
H
R
Q
D
Y
E
L
Q
D
F
G
P
Site 172
Y2137
L
Q
D
F
G
P
G
Y
S
D
E
E
P
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation