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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HMGCS1
Full Name:
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Alias:
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMCS1; HMG-CoA synthase; HMGCS; hydroxymethylglutaryl-CoA synthase, cytoplasmic
Type:
Lipid Metabolism - synthesis and degradation of ketone bodies; EC 2.3.3.10; Transferase; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis
Mass (Da):
57294
Number AA:
520
UniProt ID:
Q01581
International Prot ID:
IPI00008475
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0004421
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
GO:0008299
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
P
G
S
L
P
L
N
A
E
A
Site 2
S28
A
L
E
I
Y
F
P
S
Q
Y
V
D
Q
A
E
Site 3
Y30
E
I
Y
F
P
S
Q
Y
V
D
Q
A
E
L
E
Site 4
Y39
D
Q
A
E
L
E
K
Y
D
G
V
D
A
G
K
Site 5
Y47
D
G
V
D
A
G
K
Y
T
I
G
L
G
Q
A
Site 6
T60
Q
A
K
M
G
F
C
T
D
R
E
D
I
N
S
Site 7
S67
T
D
R
E
D
I
N
S
L
C
M
T
V
V
Q
Site 8
S83
L
M
E
R
N
N
L
S
Y
D
C
I
G
R
L
Site 9
Y84
M
E
R
N
N
L
S
Y
D
C
I
G
R
L
E
Site 10
T94
I
G
R
L
E
V
G
T
E
T
I
I
D
K
S
Site 11
S101
T
E
T
I
I
D
K
S
K
S
V
K
T
N
L
Site 12
S103
T
I
I
D
K
S
K
S
V
K
T
N
L
M
Q
Site 13
T118
L
F
E
E
S
G
N
T
D
I
E
G
I
D
T
Site 14
T125
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Site 15
S147
V
N
W
I
E
S
S
S
W
D
G
R
Y
A
L
Site 16
Y152
S
S
S
W
D
G
R
Y
A
L
V
V
A
G
D
Site 17
Y202
G
T
H
M
Q
H
A
Y
D
F
Y
K
P
D
M
Site 18
Y205
M
Q
H
A
Y
D
F
Y
K
P
D
M
L
S
E
Site 19
S211
F
Y
K
P
D
M
L
S
E
Y
P
I
V
D
G
Site 20
Y213
K
P
D
M
L
S
E
Y
P
I
V
D
G
K
L
Site 21
Y236
L
D
R
C
Y
S
V
Y
C
K
K
I
H
A
Q
Site 22
S293
D
Q
N
R
D
K
N
S
I
Y
S
G
L
E
A
Site 23
Y310
D
V
K
L
E
D
T
Y
F
D
R
D
V
E
K
Site 24
S323
E
K
A
F
M
K
A
S
S
E
L
F
S
Q
K
Site 25
S324
K
A
F
M
K
A
S
S
E
L
F
S
Q
K
T
Site 26
S328
K
A
S
S
E
L
F
S
Q
K
T
K
A
S
L
Site 27
T331
S
E
L
F
S
Q
K
T
K
A
S
L
L
V
S
Site 28
S334
F
S
Q
K
T
K
A
S
L
L
V
S
N
Q
N
Site 29
S338
T
K
A
S
L
L
V
S
N
Q
N
G
N
M
Y
Site 30
Y345
S
N
Q
N
G
N
M
Y
T
S
S
V
Y
G
S
Site 31
S348
N
G
N
M
Y
T
S
S
V
Y
G
S
L
A
S
Site 32
S361
A
S
V
L
A
Q
Y
S
P
Q
Q
L
A
G
K
Site 33
T389
T
L
Y
S
L
K
V
T
Q
D
A
T
P
G
S
Site 34
T393
L
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Site 35
S396
T
Q
D
A
T
P
G
S
A
L
D
K
I
T
A
Site 36
S404
A
L
D
K
I
T
A
S
L
C
D
L
K
S
R
Site 37
S410
A
S
L
C
D
L
K
S
R
L
D
S
R
T
G
Site 38
S414
D
L
K
S
R
L
D
S
R
T
G
V
A
P
D
Site 39
T416
K
S
R
L
D
S
R
T
G
V
A
P
D
V
F
Site 40
Y439
D
T
H
H
L
V
N
Y
I
P
Q
G
S
I
D
Site 41
S444
V
N
Y
I
P
Q
G
S
I
D
S
L
F
E
G
Site 42
S447
I
P
Q
G
S
I
D
S
L
F
E
G
T
W
Y
Site 43
Y454
S
L
F
E
G
T
W
Y
L
V
R
V
D
E
K
Site 44
T465
V
D
E
K
H
R
R
T
Y
A
R
R
P
T
P
Site 45
Y466
D
E
K
H
R
R
T
Y
A
R
R
P
T
P
N
Site 46
T471
R
T
Y
A
R
R
P
T
P
N
D
D
T
L
D
Site 47
T476
R
P
T
P
N
D
D
T
L
D
E
G
V
G
L
Site 48
S486
E
G
V
G
L
V
H
S
N
I
A
T
E
H
I
Site 49
T490
L
V
H
S
N
I
A
T
E
H
I
P
S
P
A
Site 50
S495
I
A
T
E
H
I
P
S
P
A
K
K
V
P
R
Site 51
S516
E
P
E
A
A
V
I
S
N
G
E
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation