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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AMPD2
Full Name:
AMP deaminase 2
Alias:
Adenosine monophosphate deaminase 2 (isoform L); AMD2; AMP deaminase 2; AMP deaminase isoform L; EC 3.5.4.6
Type:
Enzyme, hydrolase, Nucleotide Metabolism group, Purine metabolism family
Mass (Da):
100688
Number AA:
879
UniProt ID:
Q01433
International Prot ID:
IPI00745772
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003876
GO:0006163
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
GO:0006144
GO:0009168
GO:0006164
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
G
L
F
R
L
R
S
R
C
F
L
H
Q
S
Site 2
S20
S
R
C
F
L
H
Q
S
L
P
L
G
A
G
R
Site 3
S39
D
V
A
E
P
G
P
S
R
C
R
S
D
S
P
Site 4
S43
P
G
P
S
R
C
R
S
D
S
P
A
V
A
A
Site 5
S45
P
S
R
C
R
S
D
S
P
A
V
A
A
V
V
Site 6
Y58
V
V
P
A
M
A
S
Y
P
S
G
S
G
K
P
Site 7
S60
P
A
M
A
S
Y
P
S
G
S
G
K
P
K
A
Site 8
S62
M
A
S
Y
P
S
G
S
G
K
P
K
A
K
Y
Site 9
Y69
S
G
K
P
K
A
K
Y
P
F
K
K
R
A
S
Site 10
S76
Y
P
F
K
K
R
A
S
L
Q
A
S
T
A
A
Site 11
S80
K
R
A
S
L
Q
A
S
T
A
A
P
E
A
R
Site 12
S97
L
G
A
P
P
L
Q
S
A
R
S
L
P
G
P
Site 13
S100
P
P
L
Q
S
A
R
S
L
P
G
P
A
P
C
Site 14
T117
H
F
P
L
D
L
R
T
S
M
D
G
K
C
K
Site 15
S118
F
P
L
D
L
R
T
S
M
D
G
K
C
K
E
Site 16
T132
E
I
A
E
E
L
F
T
R
S
L
A
E
S
E
Site 17
S134
A
E
E
L
F
T
R
S
L
A
E
S
E
L
R
Site 18
S138
F
T
R
S
L
A
E
S
E
L
R
S
A
P
Y
Site 19
S142
L
A
E
S
E
L
R
S
A
P
Y
E
F
P
E
Site 20
Y145
S
E
L
R
S
A
P
Y
E
F
P
E
E
S
P
Site 21
S151
P
Y
E
F
P
E
E
S
P
I
E
Q
L
E
E
Site 22
S168
Q
R
L
E
R
Q
I
S
Q
D
V
K
L
E
P
Site 23
T188
A
K
Q
D
F
L
K
T
D
S
D
S
D
L
Q
Site 24
S190
Q
D
F
L
K
T
D
S
D
S
D
L
Q
L
Y
Site 25
S192
F
L
K
T
D
S
D
S
D
L
Q
L
Y
K
E
Site 26
Y197
S
D
S
D
L
Q
L
Y
K
E
Q
G
E
G
Q
Site 27
S208
G
E
G
Q
G
D
R
S
L
R
E
R
D
V
L
Site 28
T223
E
R
E
F
Q
R
V
T
I
S
G
E
E
K
C
Site 29
S225
E
F
Q
R
V
T
I
S
G
E
E
K
C
G
V
Site 30
S258
R
E
K
Y
M
A
L
S
L
Q
S
F
C
P
T
Site 31
S261
Y
M
A
L
S
L
Q
S
F
C
P
T
T
R
R
Site 32
T265
S
L
Q
S
F
C
P
T
T
R
R
Y
L
Q
Q
Site 33
T266
L
Q
S
F
C
P
T
T
R
R
Y
L
Q
Q
L
Site 34
Y269
F
C
P
T
T
R
R
Y
L
Q
Q
L
A
E
K
Site 35
T280
L
A
E
K
P
L
E
T
R
T
Y
E
Q
G
P
Site 36
Y283
K
P
L
E
T
R
T
Y
E
Q
G
P
D
T
P
Site 37
T289
T
Y
E
Q
G
P
D
T
P
V
S
A
D
A
P
Site 38
S292
Q
G
P
D
T
P
V
S
A
D
A
P
V
H
P
Site 39
Y307
P
A
L
E
Q
H
P
Y
E
H
C
E
P
S
T
Site 40
S313
P
Y
E
H
C
E
P
S
T
M
P
G
D
L
G
Site 41
T314
Y
E
H
C
E
P
S
T
M
P
G
D
L
G
L
Site 42
Y333
V
R
G
V
V
H
V
Y
T
R
R
E
P
D
E
Site 43
T334
R
G
V
V
H
V
Y
T
R
R
E
P
D
E
H
Site 44
S343
R
E
P
D
E
H
C
S
E
V
E
L
P
Y
P
Site 45
Y349
C
S
E
V
E
L
P
Y
P
D
L
Q
E
F
V
Site 46
Y376
G
P
I
K
S
F
C
Y
R
R
L
Q
Y
L
S
Site 47
Y381
F
C
Y
R
R
L
Q
Y
L
S
S
K
F
Q
M
Site 48
S384
R
R
L
Q
Y
L
S
S
K
F
Q
M
H
V
L
Site 49
Y410
K
V
P
H
R
D
F
Y
N
I
R
K
V
D
T
Site 50
T455
V
E
Q
G
R
E
Q
T
L
R
E
V
F
E
S
Site 51
S462
T
L
R
E
V
F
E
S
M
N
L
T
A
Y
D
Site 52
Y468
E
S
M
N
L
T
A
Y
D
L
S
V
D
T
L
Site 53
S471
N
L
T
A
Y
D
L
S
V
D
T
L
D
V
H
Site 54
T474
A
Y
D
L
S
V
D
T
L
D
V
H
A
D
R
Site 55
T483
D
V
H
A
D
R
N
T
F
H
R
F
D
K
F
Site 56
Y494
F
D
K
F
N
A
K
Y
N
P
I
G
E
S
V
Site 57
S500
K
Y
N
P
I
G
E
S
V
L
R
E
I
F
I
Site 58
T509
L
R
E
I
F
I
K
T
D
N
R
V
S
G
K
Site 59
Y517
D
N
R
V
S
G
K
Y
F
A
H
I
I
K
E
Site 60
S527
H
I
I
K
E
V
M
S
D
L
E
E
S
K
Y
Site 61
Y534
S
D
L
E
E
S
K
Y
Q
N
A
E
L
R
L
Site 62
S542
Q
N
A
E
L
R
L
S
I
Y
G
R
S
R
D
Site 63
Y544
A
E
L
R
L
S
I
Y
G
R
S
R
D
E
W
Site 64
Y581
V
P
R
L
F
D
V
Y
R
T
K
G
Q
L
A
Site 65
S610
E
A
T
V
H
P
A
S
H
P
E
L
H
L
F
Site 66
S626
E
H
V
D
G
F
D
S
V
D
D
E
S
K
P
Site 67
S631
F
D
S
V
D
D
E
S
K
P
E
N
H
V
F
Site 68
S642
N
H
V
F
N
L
E
S
P
L
P
E
A
W
V
Site 69
Y656
V
E
E
D
N
P
P
Y
A
Y
Y
L
Y
Y
T
Site 70
Y659
D
N
P
P
Y
A
Y
Y
L
Y
Y
T
F
A
N
Site 71
Y661
P
P
Y
A
Y
Y
L
Y
Y
T
F
A
N
M
A
Site 72
T681
R
R
Q
R
G
F
H
T
F
V
L
R
P
H
C
Site 73
S739
M
S
P
L
S
N
N
S
L
F
L
S
Y
H
R
Site 74
S743
S
N
N
S
L
F
L
S
Y
H
R
N
P
L
P
Site 75
Y752
H
R
N
P
L
P
E
Y
L
S
R
G
L
M
V
Site 76
S762
R
G
L
M
V
S
L
S
T
D
D
P
L
Q
F
Site 77
T772
D
P
L
Q
F
H
F
T
K
E
P
L
M
E
E
Site 78
S781
E
P
L
M
E
E
Y
S
I
A
T
Q
V
W
K
Site 79
S805
A
R
N
S
V
L
M
S
G
F
S
H
K
V
K
Site 80
S808
S
V
L
M
S
G
F
S
H
K
V
K
S
H
W
Site 81
Y820
S
H
W
L
G
P
N
Y
T
K
E
G
P
E
G
Site 82
T833
E
G
N
D
I
R
R
T
N
V
P
D
I
R
V
Site 83
Y842
V
P
D
I
R
V
G
Y
R
Y
E
T
L
C
Q
Site 84
Y844
D
I
R
V
G
Y
R
Y
E
T
L
C
Q
E
L
Site 85
T846
R
V
G
Y
R
Y
E
T
L
C
Q
E
L
A
L
Site 86
T865
V
Q
S
E
M
L
E
T
I
P
E
E
A
G
I
Site 87
T873
I
P
E
E
A
G
I
T
M
S
P
G
P
Q
_
Site 88
S875
E
E
A
G
I
T
M
S
P
G
P
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation