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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTBN1
Full Name:
Spectrin beta chain, brain 1
Alias:
Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1
Type:
Cytoskeletal protein
Mass (Da):
274609
Number AA:
2364
UniProt ID:
Q01082
International Prot ID:
IPI00871932
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005198
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0000060
GO:0006464
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
T
T
T
V
A
T
D
Y
D
N
I
E
I
Q
Q
Site 2
S35
D
D
W
D
N
E
N
S
S
A
R
L
F
E
R
Site 3
S36
D
W
D
N
E
N
S
S
A
R
L
F
E
R
S
Site 4
S43
S
A
R
L
F
E
R
S
R
I
K
A
L
A
D
Site 5
T59
R
E
A
V
Q
K
K
T
F
T
K
W
V
N
S
Site 6
T61
A
V
Q
K
K
T
F
T
K
W
V
N
S
H
L
Site 7
S72
N
S
H
L
A
R
V
S
C
R
I
T
D
L
Y
Site 8
T76
A
R
V
S
C
R
I
T
D
L
Y
T
D
L
R
Site 9
Y79
S
C
R
I
T
D
L
Y
T
D
L
R
D
G
R
Site 10
T80
C
R
I
T
D
L
Y
T
D
L
R
D
G
R
M
Site 11
S96
I
K
L
L
E
V
L
S
G
E
R
L
P
K
P
Site 12
T104
G
E
R
L
P
K
P
T
K
G
R
M
R
I
H
Site 13
S163
R
F
Q
I
Q
D
I
S
V
E
T
E
D
N
K
Site 14
S174
E
D
N
K
E
K
K
S
A
K
D
A
L
L
L
Site 15
S228
D
F
D
K
L
K
K
S
N
A
H
Y
N
L
Q
Site 16
Y232
L
K
K
S
N
A
H
Y
N
L
Q
N
A
F
N
Site 17
S257
L
L
D
P
E
D
I
S
V
D
H
P
D
E
K
Site 18
S265
V
D
H
P
D
E
K
S
I
I
T
Y
V
V
T
Site 19
Y269
D
E
K
S
I
I
T
Y
V
V
T
Y
Y
H
Y
Site 20
Y274
I
T
Y
V
V
T
Y
Y
H
Y
F
S
K
M
K
Site 21
Y276
Y
V
V
T
Y
Y
H
Y
F
S
K
M
K
A
L
Site 22
Y307
T
E
K
M
I
E
K
Y
E
S
L
A
S
D
L
Site 23
S309
K
M
I
E
K
Y
E
S
L
A
S
D
L
L
E
Site 24
S312
E
K
Y
E
S
L
A
S
D
L
L
E
W
I
E
Site 25
S333
N
N
R
K
F
A
N
S
L
V
G
V
Q
Q
Q
Site 26
T346
Q
Q
L
Q
A
F
N
T
Y
R
T
V
E
K
P
Site 27
Y381
R
A
N
N
Q
K
V
Y
M
P
R
E
G
K
L
Site 28
S390
P
R
E
G
K
L
I
S
D
I
N
K
A
W
E
Site 29
T436
R
K
A
A
M
R
E
T
W
L
S
E
N
Q
R
Site 30
S439
A
M
R
E
T
W
L
S
E
N
Q
R
L
V
S
Site 31
S446
S
E
N
Q
R
L
V
S
Q
D
N
F
G
F
D
Site 32
T469
K
K
H
E
A
I
E
T
D
I
A
A
Y
E
E
Site 33
Y493
R
E
L
E
A
E
N
Y
H
D
I
K
R
I
T
Site 34
T500
Y
H
D
I
K
R
I
T
A
R
K
D
N
V
I
Site 35
S553
E
M
K
V
L
V
L
S
Q
D
Y
G
K
H
L
Site 36
S590
R
V
R
G
V
N
A
S
A
Q
K
F
A
T
D
Site 37
Y620
V
A
H
M
E
F
C
Y
Q
E
L
C
Q
L
A
Site 38
S637
R
R
A
R
L
E
E
S
R
R
L
W
K
F
F
Site 39
S662
R
E
K
E
K
I
L
S
S
D
D
Y
G
K
D
Site 40
S663
E
K
E
K
I
L
S
S
D
D
Y
G
K
D
L
Site 41
Y666
K
I
L
S
S
D
D
Y
G
K
D
L
T
S
V
Site 42
T671
D
D
Y
G
K
D
L
T
S
V
M
R
L
L
S
Site 43
S672
D
Y
G
K
D
L
T
S
V
M
R
L
L
S
K
Site 44
S678
T
S
V
M
R
L
L
S
K
H
R
A
F
E
D
Site 45
S688
R
A
F
E
D
E
M
S
G
R
S
G
H
F
E
Site 46
S712
I
A
E
E
H
F
G
S
E
K
I
R
E
R
I
Site 47
Y721
K
I
R
E
R
I
I
Y
I
R
E
Q
W
A
N
Site 48
S744
K
K
R
L
E
E
A
S
L
L
H
Q
F
Q
A
Site 49
S769
D
I
L
K
I
V
S
S
S
D
V
G
H
D
E
Site 50
S770
I
L
K
I
V
S
S
S
D
V
G
H
D
E
Y
Site 51
Y777
S
D
V
G
H
D
E
Y
S
T
Q
S
L
V
K
Site 52
T779
V
G
H
D
E
Y
S
T
Q
S
L
V
K
K
H
Site 53
S781
H
D
E
Y
S
T
Q
S
L
V
K
K
H
K
D
Site 54
Y796
V
A
E
E
I
A
N
Y
R
P
T
L
D
T
L
Site 55
T799
E
I
A
N
Y
R
P
T
L
D
T
L
H
E
Q
Site 56
T802
N
Y
R
P
T
L
D
T
L
H
E
Q
A
S
A
Site 57
S808
D
T
L
H
E
Q
A
S
A
L
P
Q
E
H
A
Site 58
S817
L
P
Q
E
H
A
E
S
P
D
V
R
G
R
L
Site 59
S825
P
D
V
R
G
R
L
S
G
I
E
E
R
Y
K
Site 60
Y831
L
S
G
I
E
E
R
Y
K
E
V
A
E
L
T
Site 61
T838
Y
K
E
V
A
E
L
T
R
L
R
K
Q
A
L
Site 62
T848
R
K
Q
A
L
Q
D
T
L
A
L
Y
K
M
F
Site 63
Y852
L
Q
D
T
L
A
L
Y
K
M
F
S
E
A
D
Site 64
S893
V
I
Q
H
R
F
E
S
L
E
P
E
M
N
N
Site 65
S918
I
A
R
Q
L
M
H
S
G
H
P
S
E
K
E
Site 66
S922
L
M
H
S
G
H
P
S
E
K
E
I
K
A
Q
Site 67
S938
D
K
L
N
T
R
W
S
Q
F
R
E
L
V
D
Site 68
S953
R
K
K
D
A
L
L
S
A
L
S
I
Q
N
Y
Site 69
Y960
S
A
L
S
I
Q
N
Y
H
L
E
C
N
E
T
Site 70
S969
L
E
C
N
E
T
K
S
W
I
R
E
K
T
K
Site 71
T975
K
S
W
I
R
E
K
T
K
V
I
E
S
T
Q
Site 72
T999
M
A
L
Q
R
K
L
T
G
M
E
R
D
L
V
Site 73
S1013
V
A
I
E
A
K
L
S
D
L
Q
K
E
A
E
Site 74
S1024
K
E
A
E
K
L
E
S
E
H
P
D
Q
A
Q
Site 75
S1035
D
Q
A
Q
A
I
L
S
R
L
A
E
I
S
D
Site 76
S1041
L
S
R
L
A
E
I
S
D
V
W
E
E
M
K
Site 77
T1049
D
V
W
E
E
M
K
T
T
L
K
N
R
E
A
Site 78
T1050
V
W
E
E
M
K
T
T
L
K
N
R
E
A
S
Site 79
S1057
T
L
K
N
R
E
A
S
L
G
E
A
S
K
L
Site 80
S1076
R
D
L
D
D
F
Q
S
W
L
S
R
T
Q
T
Site 81
T1083
S
W
L
S
R
T
Q
T
A
I
A
S
E
D
M
Site 82
T1095
E
D
M
P
N
T
L
T
E
A
E
K
L
L
T
Site 83
T1102
T
E
A
E
K
L
L
T
Q
H
E
N
I
K
N
Site 84
Y1114
I
K
N
E
I
D
N
Y
E
E
D
Y
Q
K
M
Site 85
Y1118
I
D
N
Y
E
E
D
Y
Q
K
M
R
D
M
G
Site 86
Y1137
Q
G
Q
T
D
A
Q
Y
M
F
L
R
Q
R
L
Site 87
T1149
Q
R
L
Q
A
L
D
T
G
W
N
E
L
H
K
Site 88
S1166
E
N
R
Q
N
L
L
S
Q
S
H
A
Y
Q
Q
Site 89
Y1171
L
L
S
Q
S
H
A
Y
Q
Q
F
L
R
D
T
Site 90
T1178
Y
Q
Q
F
L
R
D
T
K
Q
A
E
A
F
L
Site 91
Y1190
A
F
L
N
N
Q
E
Y
V
L
A
H
T
E
M
Site 92
T1195
Q
E
Y
V
L
A
H
T
E
M
P
T
T
L
E
Site 93
T1200
A
H
T
E
M
P
T
T
L
E
G
A
E
A
A
Site 94
T1216
K
K
Q
E
D
F
M
T
T
M
D
A
N
E
E
Site 95
T1217
K
Q
E
D
F
M
T
T
M
D
A
N
E
E
K
Site 96
T1231
K
I
N
A
V
V
E
T
G
R
R
L
V
S
D
Site 97
S1237
E
T
G
R
R
L
V
S
D
G
N
I
N
S
D
Site 98
S1243
V
S
D
G
N
I
N
S
D
R
I
Q
E
K
V
Site 99
S1252
R
I
Q
E
K
V
D
S
I
D
D
R
H
R
K
Site 100
T1263
R
H
R
K
N
R
E
T
A
S
E
L
L
M
R
Site 101
S1302
M
L
T
A
Q
D
M
S
Y
D
E
A
R
N
L
Site 102
Y1303
L
T
A
Q
D
M
S
Y
D
E
A
R
N
L
H
Site 103
T1347
L
I
S
E
K
P
E
T
E
A
V
V
K
E
K
Site 104
S1367
K
M
W
E
V
L
E
S
T
T
Q
T
K
A
Q
Site 105
T1371
V
L
E
S
T
T
Q
T
K
A
Q
R
L
F
D
Site 106
S1388
K
A
E
L
F
T
Q
S
C
A
D
L
D
K
W
Site 107
S1401
K
W
L
H
G
L
E
S
Q
I
Q
S
D
D
Y
Site 108
S1405
G
L
E
S
Q
I
Q
S
D
D
Y
G
K
D
L
Site 109
Y1408
S
Q
I
Q
S
D
D
Y
G
K
D
L
T
S
V
Site 110
T1413
D
D
Y
G
K
D
L
T
S
V
N
I
L
L
K
Site 111
S1414
D
Y
G
K
D
L
T
S
V
N
I
L
L
K
K
Site 112
S1441
K
E
I
E
E
L
Q
S
Q
A
Q
A
L
S
Q
Site 113
S1447
Q
S
Q
A
Q
A
L
S
Q
E
G
K
S
T
D
Site 114
S1452
A
L
S
Q
E
G
K
S
T
D
E
V
D
S
K
Site 115
T1453
L
S
Q
E
G
K
S
T
D
E
V
D
S
K
R
Site 116
S1458
K
S
T
D
E
V
D
S
K
R
L
T
V
Q
T
Site 117
T1462
E
V
D
S
K
R
L
T
V
Q
T
K
F
M
E
Site 118
T1465
S
K
R
L
T
V
Q
T
K
F
M
E
L
L
E
Site 119
S1484
R
K
H
N
L
L
A
S
K
E
I
H
Q
F
N
Site 120
T1509
G
E
R
M
P
L
A
T
S
T
D
H
G
H
N
Site 121
T1519
D
H
G
H
N
L
Q
T
V
Q
L
L
I
K
K
Site 122
S1548
I
D
D
I
F
E
R
S
Q
N
I
V
T
D
S
Site 123
T1553
E
R
S
Q
N
I
V
T
D
S
S
S
L
S
A
Site 124
S1555
S
Q
N
I
V
T
D
S
S
S
L
S
A
E
A
Site 125
S1557
N
I
V
T
D
S
S
S
L
S
A
E
A
I
R
Site 126
S1559
V
T
D
S
S
S
L
S
A
E
A
I
R
Q
R
Site 127
T1581
W
G
L
L
I
E
E
T
E
K
R
H
R
R
L
Site 128
Y1598
A
H
R
A
Q
Q
Y
Y
F
D
A
A
E
A
E
Site 129
Y1614
W
M
S
E
Q
E
L
Y
M
M
S
E
E
K
A
Site 130
S1626
E
K
A
K
D
E
Q
S
A
V
S
M
L
K
K
Site 131
Y1644
L
E
Q
A
V
E
D
Y
A
E
T
V
H
Q
L
Site 132
T1647
A
V
E
D
Y
A
E
T
V
H
Q
L
S
K
T
Site 133
S1652
A
E
T
V
H
Q
L
S
K
T
S
R
A
L
V
Site 134
T1654
T
V
H
Q
L
S
K
T
S
R
A
L
V
A
D
Site 135
S1662
S
R
A
L
V
A
D
S
H
P
E
S
E
R
I
Site 136
S1666
V
A
D
S
H
P
E
S
E
R
I
S
M
R
Q
Site 137
S1670
H
P
E
S
E
R
I
S
M
R
Q
S
K
V
D
Site 138
S1674
E
R
I
S
M
R
Q
S
K
V
D
K
L
Y
A
Site 139
Y1680
Q
S
K
V
D
K
L
Y
A
G
L
K
D
L
A
Site 140
Y1730
S
H
E
L
G
Q
D
Y
E
H
V
T
M
L
Q
Site 141
T1734
G
Q
D
Y
E
H
V
T
M
L
Q
E
R
F
R
Site 142
T1747
F
R
E
F
A
R
D
T
G
N
I
G
Q
E
R
Site 143
T1757
I
G
Q
E
R
V
D
T
V
N
H
L
A
D
E
Site 144
S1768
L
A
D
E
L
I
N
S
G
H
S
D
A
A
T
Site 145
T1775
S
G
H
S
D
A
A
T
I
A
E
W
K
D
G
Site 146
Y1805
T
Q
I
L
A
A
S
Y
E
L
H
K
F
Y
H
Site 147
Y1811
S
Y
E
L
H
K
F
Y
H
D
A
K
E
I
F
Site 148
T1838
E
L
G
R
D
Q
N
T
V
E
T
L
Q
R
M
Site 149
T1841
R
D
Q
N
T
V
E
T
L
Q
R
M
H
T
T
Site 150
T1847
E
T
L
Q
R
M
H
T
T
F
E
H
D
I
Q
Site 151
S1895
E
V
L
E
A
W
K
S
L
L
D
A
C
E
S
Site 152
S1902
S
L
L
D
A
C
E
S
R
R
V
R
L
V
D
Site 153
T1910
R
R
V
R
L
V
D
T
G
D
K
F
R
F
F
Site 154
S1918
G
D
K
F
R
F
F
S
M
V
R
D
L
M
L
Site 155
S1944
Q
E
K
P
R
D
V
S
S
V
E
L
L
M
N
Site 156
S1945
E
K
P
R
D
V
S
S
V
E
L
L
M
N
N
Site 157
S1966
E
I
D
A
R
N
D
S
F
T
T
C
I
E
L
Site 158
T1968
D
A
R
N
D
S
F
T
T
C
I
E
L
G
K
Site 159
S1976
T
C
I
E
L
G
K
S
L
L
A
R
K
H
Y
Site 160
Y1983
S
L
L
A
R
K
H
Y
A
S
E
E
I
K
E
Site 161
S1985
L
A
R
K
H
Y
A
S
E
E
I
K
E
K
L
Site 162
S2023
I
L
E
V
H
Q
F
S
R
D
A
S
V
A
E
Site 163
S2027
H
Q
F
S
R
D
A
S
V
A
E
A
W
L
L
Site 164
Y2039
W
L
L
G
Q
E
P
Y
L
S
S
R
E
I
G
Site 165
S2041
L
G
Q
E
P
Y
L
S
S
R
E
I
G
Q
S
Site 166
S2048
S
S
R
E
I
G
Q
S
V
D
E
V
E
K
L
Site 167
S2065
R
H
E
A
F
E
K
S
A
A
T
W
D
E
R
Site 168
T2068
A
F
E
K
S
A
A
T
W
D
E
R
F
S
A
Site 169
S2074
A
T
W
D
E
R
F
S
A
L
E
R
L
T
T
Site 170
T2080
F
S
A
L
E
R
L
T
T
L
E
L
L
E
V
Site 171
T2081
S
A
L
E
R
L
T
T
L
E
L
L
E
V
R
Site 172
S2102
E
R
K
R
R
P
P
S
P
E
P
S
T
K
V
Site 173
S2106
R
P
P
S
P
E
P
S
T
K
V
S
E
E
A
Site 174
T2107
P
P
S
P
E
P
S
T
K
V
S
E
E
A
E
Site 175
S2110
P
E
P
S
T
K
V
S
E
E
A
E
S
Q
Q
Site 176
S2115
K
V
S
E
E
A
E
S
Q
Q
Q
W
D
T
S
Site 177
T2121
E
S
Q
Q
Q
W
D
T
S
K
G
E
Q
V
S
Site 178
S2122
S
Q
Q
Q
W
D
T
S
K
G
E
Q
V
S
Q
Site 179
S2128
T
S
K
G
E
Q
V
S
Q
N
G
L
P
A
E
Site 180
S2138
G
L
P
A
E
Q
G
S
P
R
M
A
E
T
V
Site 181
T2144
G
S
P
R
M
A
E
T
V
D
T
S
E
M
V
Site 182
T2147
R
M
A
E
T
V
D
T
S
E
M
V
N
G
A
Site 183
S2148
M
A
E
T
V
D
T
S
E
M
V
N
G
A
T
Site 184
T2155
S
E
M
V
N
G
A
T
E
Q
R
T
S
S
K
Site 185
T2159
N
G
A
T
E
Q
R
T
S
S
K
E
S
S
P
Site 186
S2160
G
A
T
E
Q
R
T
S
S
K
E
S
S
P
I
Site 187
S2161
A
T
E
Q
R
T
S
S
K
E
S
S
P
I
P
Site 188
S2164
Q
R
T
S
S
K
E
S
S
P
I
P
S
P
T
Site 189
S2165
R
T
S
S
K
E
S
S
P
I
P
S
P
T
S
Site 190
S2169
K
E
S
S
P
I
P
S
P
T
S
D
R
K
A
Site 191
T2171
S
S
P
I
P
S
P
T
S
D
R
K
A
K
T
Site 192
S2172
S
P
I
P
S
P
T
S
D
R
K
A
K
T
A
Site 193
T2178
T
S
D
R
K
A
K
T
A
L
P
A
Q
S
A
Site 194
T2187
L
P
A
Q
S
A
A
T
L
P
A
R
T
Q
E
Site 195
T2192
A
A
T
L
P
A
R
T
Q
E
T
P
S
A
Q
Site 196
T2195
L
P
A
R
T
Q
E
T
P
S
A
Q
M
E
G
Site 197
S2218
E
A
H
N
K
K
A
S
S
R
S
W
H
N
V
Site 198
S2221
N
K
K
A
S
S
R
S
W
H
N
V
Y
C
V
Site 199
Y2226
S
R
S
W
H
N
V
Y
C
V
I
N
N
Q
E
Site 200
Y2237
N
N
Q
E
M
G
F
Y
K
D
A
K
T
A
A
Site 201
T2242
G
F
Y
K
D
A
K
T
A
A
S
G
I
P
Y
Site 202
Y2249
T
A
A
S
G
I
P
Y
H
S
E
V
P
V
S
Site 203
S2251
A
S
G
I
P
Y
H
S
E
V
P
V
S
L
K
Site 204
S2256
Y
H
S
E
V
P
V
S
L
K
E
A
V
C
E
Site 205
Y2268
V
C
E
V
A
L
D
Y
K
K
K
K
H
V
F
Site 206
T2297
K
D
D
E
E
M
N
T
W
I
Q
A
I
S
S
Site 207
S2303
N
T
W
I
Q
A
I
S
S
A
I
S
S
D
K
Site 208
S2304
T
W
I
Q
A
I
S
S
A
I
S
S
D
K
H
Site 209
S2307
Q
A
I
S
S
A
I
S
S
D
K
H
E
V
S
Site 210
S2308
A
I
S
S
A
I
S
S
D
K
H
E
V
S
A
Site 211
S2314
S
S
D
K
H
E
V
S
A
S
T
Q
S
T
P
Site 212
S2316
D
K
H
E
V
S
A
S
T
Q
S
T
P
A
S
Site 213
T2317
K
H
E
V
S
A
S
T
Q
S
T
P
A
S
S
Site 214
S2319
E
V
S
A
S
T
Q
S
T
P
A
S
S
R
A
Site 215
T2320
V
S
A
S
T
Q
S
T
P
A
S
S
R
A
Q
Site 216
S2323
S
T
Q
S
T
P
A
S
S
R
A
Q
T
L
P
Site 217
S2324
T
Q
S
T
P
A
S
S
R
A
Q
T
L
P
T
Site 218
T2328
P
A
S
S
R
A
Q
T
L
P
T
S
V
V
T
Site 219
T2331
S
R
A
Q
T
L
P
T
S
V
V
T
I
T
S
Site 220
S2332
R
A
Q
T
L
P
T
S
V
V
T
I
T
S
E
Site 221
T2335
T
L
P
T
S
V
V
T
I
T
S
E
S
S
P
Site 222
T2337
P
T
S
V
V
T
I
T
S
E
S
S
P
G
K
Site 223
S2338
T
S
V
V
T
I
T
S
E
S
S
P
G
K
R
Site 224
S2340
V
V
T
I
T
S
E
S
S
P
G
K
R
E
K
Site 225
S2341
V
T
I
T
S
E
S
S
P
G
K
R
E
K
D
Site 226
S2358
K
D
K
E
K
R
F
S
L
F
G
K
K
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation