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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAT1A
Full Name:
S-adenosylmethionine synthase isoform type-1
Alias:
Methionine adenosyltransferase 1;Methionine adenosyltransferase I/III
Type:
Enzyme, transferase
Mass (Da):
43648
Number AA:
395
UniProt ID:
Q00266
International Prot ID:
IPI00021772
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0050897
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006520
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
E
G
V
F
M
F
T
S
E
S
V
G
E
G
H
Site 2
S24
V
F
M
F
T
S
E
S
V
G
E
G
H
P
D
Site 3
S38
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
Site 4
Y79
T
S
M
A
M
V
D
Y
Q
R
V
V
R
D
T
Site 5
Y92
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
Site 6
S95
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
Site 7
T146
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
Site 8
S170
R
M
A
D
L
R
R
S
G
L
L
P
W
L
R
Site 9
S180
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Site 10
T182
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Site 11
Y188
K
T
Q
V
T
V
Q
Y
M
Q
D
N
G
A
V
Site 12
S206
R
I
H
T
I
V
I
S
V
Q
H
N
E
D
I
Site 13
T214
V
Q
H
N
E
D
I
T
L
E
E
M
R
R
A
Site 14
Y235
R
A
V
V
P
A
K
Y
L
D
E
D
T
V
Y
Site 15
T240
A
K
Y
L
D
E
D
T
V
Y
H
L
Q
P
S
Site 16
Y242
Y
L
D
E
D
T
V
Y
H
L
Q
P
S
G
R
Site 17
T270
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
Site 18
Y271
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
Site 19
S283
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
Site 20
Y287
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
Site 21
T288
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Site 22
S293
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
Site 23
Y296
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
Site 24
Y335
L
S
I
S
I
F
T
Y
G
T
S
Q
K
T
E
Site 25
S338
S
I
F
T
Y
G
T
S
Q
K
T
E
R
E
L
Site 26
T341
T
Y
G
T
S
Q
K
T
E
R
E
L
L
D
V
Site 27
Y371
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation