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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DAB2
Full Name:
Disabled homolog 2
Alias:
Differentially expressed protein 2; Differentially-expressed protein 2; Disabled 2; Disabled 2, mitogen-responsive phosphoprotein; DOC2; DOC-2; Mitogen-responsive phosphoprotein
Type:
Adapter/scaffold protein
Mass (Da):
82448
Number AA:
770
UniProt ID:
P98082
International Prot ID:
IPI00179438
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030665
GO:0005905
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
N
E
V
E
T
S
A
T
N
G
Q
P
D
Site 2
S24
Q
A
A
P
K
A
P
S
K
K
E
K
K
K
G
Site 3
T35
K
K
K
G
P
E
K
T
D
E
Y
L
L
A
R
Site 4
Y38
G
P
E
K
T
D
E
Y
L
L
A
R
F
K
G
Site 5
Y50
F
K
G
D
G
V
K
Y
K
A
K
L
I
G
I
Site 6
S69
D
A
R
G
D
K
M
S
Q
D
S
M
M
K
L
Site 7
S72
G
D
K
M
S
Q
D
S
M
M
K
L
K
G
M
Site 8
S98
Q
R
I
W
V
N
I
S
L
S
G
I
K
I
I
Site 9
S100
I
W
V
N
I
S
L
S
G
I
K
I
I
D
E
Site 10
T109
I
K
I
I
D
E
K
T
G
V
I
E
H
E
H
Site 11
S122
E
H
P
V
N
K
I
S
F
I
A
R
D
V
T
Site 12
T129
S
F
I
A
R
D
V
T
D
N
R
A
F
G
Y
Site 13
Y136
T
D
N
R
A
F
G
Y
V
C
G
G
E
G
Q
Site 14
T151
H
Q
F
F
A
I
K
T
G
Q
Q
A
E
P
L
Site 15
Y170
K
D
L
F
Q
V
I
Y
N
V
K
K
K
E
E
Site 16
S186
K
K
K
I
E
E
A
S
K
A
V
E
N
G
S
Site 17
S193
S
K
A
V
E
N
G
S
E
A
L
M
I
L
D
Site 18
T203
L
M
I
L
D
D
Q
T
N
K
L
K
S
G
V
Site 19
S208
D
Q
T
N
K
L
K
S
G
V
D
Q
M
D
L
Site 20
S220
M
D
L
F
G
D
M
S
T
P
P
D
L
N
S
Site 21
T221
D
L
F
G
D
M
S
T
P
P
D
L
N
S
P
Site 22
S227
S
T
P
P
D
L
N
S
P
T
E
S
K
D
I
Site 23
T229
P
P
D
L
N
S
P
T
E
S
K
D
I
L
L
Site 24
S231
D
L
N
S
P
T
E
S
K
D
I
L
L
V
D
Site 25
S241
I
L
L
V
D
L
N
S
E
I
D
T
N
Q
N
Site 26
T245
D
L
N
S
E
I
D
T
N
Q
N
S
L
R
E
Site 27
S249
E
I
D
T
N
Q
N
S
L
R
E
N
P
F
L
Site 28
T257
L
R
E
N
P
F
L
T
N
G
I
T
S
C
S
Site 29
T261
P
F
L
T
N
G
I
T
S
C
S
L
P
R
P
Site 30
S264
T
N
G
I
T
S
C
S
L
P
R
P
T
P
Q
Site 31
T269
S
C
S
L
P
R
P
T
P
Q
A
S
F
L
P
Site 32
S273
P
R
P
T
P
Q
A
S
F
L
P
E
N
A
F
Site 33
T289
A
N
L
N
F
F
P
T
P
N
P
D
P
F
R
Site 34
T301
P
F
R
D
D
P
F
T
Q
P
D
Q
S
T
P
Site 35
S306
P
F
T
Q
P
D
Q
S
T
P
S
S
F
D
S
Site 36
T307
F
T
Q
P
D
Q
S
T
P
S
S
F
D
S
L
Site 37
S309
Q
P
D
Q
S
T
P
S
S
F
D
S
L
K
S
Site 38
S310
P
D
Q
S
T
P
S
S
F
D
S
L
K
S
P
Site 39
S313
S
T
P
S
S
F
D
S
L
K
S
P
D
Q
K
Site 40
S316
S
S
F
D
S
L
K
S
P
D
Q
K
K
E
N
Site 41
S324
P
D
Q
K
K
E
N
S
S
S
S
S
T
P
L
Site 42
S325
D
Q
K
K
E
N
S
S
S
S
S
T
P
L
S
Site 43
S326
Q
K
K
E
N
S
S
S
S
S
T
P
L
S
N
Site 44
S327
K
K
E
N
S
S
S
S
S
T
P
L
S
N
G
Site 45
S328
K
E
N
S
S
S
S
S
T
P
L
S
N
G
P
Site 46
T329
E
N
S
S
S
S
S
T
P
L
S
N
G
P
L
Site 47
S332
S
S
S
S
T
P
L
S
N
G
P
L
N
G
D
Site 48
Y342
P
L
N
G
D
V
D
Y
F
G
Q
Q
F
D
Q
Site 49
S351
G
Q
Q
F
D
Q
I
S
N
R
T
G
K
Q
E
Site 50
S367
Q
A
G
P
W
P
F
S
S
S
Q
T
Q
P
A
Site 51
S368
A
G
P
W
P
F
S
S
S
Q
T
Q
P
A
V
Site 52
S369
G
P
W
P
F
S
S
S
Q
T
Q
P
A
V
R
Site 53
T371
W
P
F
S
S
S
Q
T
Q
P
A
V
R
T
Q
Site 54
S382
V
R
T
Q
N
G
V
S
E
R
E
Q
N
G
F
Site 55
S390
E
R
E
Q
N
G
F
S
V
K
S
S
P
N
P
Site 56
S393
Q
N
G
F
S
V
K
S
S
P
N
P
F
V
G
Site 57
S394
N
G
F
S
V
K
S
S
P
N
P
F
V
G
S
Site 58
S401
S
P
N
P
F
V
G
S
P
P
K
G
L
S
I
Site 59
S407
G
S
P
P
K
G
L
S
I
Q
N
G
V
K
Q
Site 60
S418
G
V
K
Q
D
L
E
S
S
V
Q
S
S
P
H
Site 61
S419
V
K
Q
D
L
E
S
S
V
Q
S
S
P
H
D
Site 62
S422
D
L
E
S
S
V
Q
S
S
P
H
D
S
I
A
Site 63
S423
L
E
S
S
V
Q
S
S
P
H
D
S
I
A
I
Site 64
S427
V
Q
S
S
P
H
D
S
I
A
I
I
P
P
P
Site 65
S436
A
I
I
P
P
P
Q
S
T
K
P
G
R
G
R
Site 66
T437
I
I
P
P
P
Q
S
T
K
P
G
R
G
R
R
Site 67
T445
K
P
G
R
G
R
R
T
A
K
S
S
A
N
D
Site 68
S448
R
G
R
R
T
A
K
S
S
A
N
D
L
L
A
Site 69
S449
G
R
R
T
A
K
S
S
A
N
D
L
L
A
S
Site 70
S464
D
I
F
A
P
P
V
S
E
P
S
G
Q
A
S
Site 71
S467
A
P
P
V
S
E
P
S
G
Q
A
S
P
T
G
Site 72
S471
S
E
P
S
G
Q
A
S
P
T
G
Q
P
T
A
Site 73
T473
P
S
G
Q
A
S
P
T
G
Q
P
T
A
L
Q
Site 74
T489
N
P
L
D
L
F
K
T
S
A
P
A
P
V
G
Site 75
S518
A
G
P
W
N
T
A
S
L
V
F
N
Q
S
P
Site 76
S541
G
G
Q
P
S
G
F
S
Q
P
V
I
F
G
T
Site 77
S553
F
G
T
S
P
A
V
S
G
W
N
Q
P
S
P
Site 78
S559
V
S
G
W
N
Q
P
S
P
F
A
A
S
T
P
Site 79
S564
Q
P
S
P
F
A
A
S
T
P
P
P
V
P
V
Site 80
S585
S
V
A
P
N
A
W
S
T
T
S
P
L
G
N
Site 81
T586
V
A
P
N
A
W
S
T
T
S
P
L
G
N
P
Site 82
S588
P
N
A
W
S
T
T
S
P
L
G
N
P
F
Q
Site 83
S605
I
F
P
A
P
A
V
S
T
Q
P
P
S
M
H
Site 84
T606
F
P
A
P
A
V
S
T
Q
P
P
S
M
H
S
Site 85
S614
Q
P
P
S
M
H
S
S
L
L
V
T
P
P
Q
Site 86
T618
M
H
S
S
L
L
V
T
P
P
Q
P
P
P
R
Site 87
S633
A
G
P
P
K
D
I
S
S
D
A
F
T
A
L
Site 88
S634
G
P
P
K
D
I
S
S
D
A
F
T
A
L
D
Site 89
T638
D
I
S
S
D
A
F
T
A
L
D
P
L
G
D
Site 90
T674
P
A
R
K
G
E
Q
T
S
S
G
T
L
S
A
Site 91
S676
R
K
G
E
Q
T
S
S
G
T
L
S
A
F
A
Site 92
T678
G
E
Q
T
S
S
G
T
L
S
A
F
A
S
Y
Site 93
S680
Q
T
S
S
G
T
L
S
A
F
A
S
Y
F
N
Site 94
S684
G
T
L
S
A
F
A
S
Y
F
N
S
K
V
G
Site 95
Y685
T
L
S
A
F
A
S
Y
F
N
S
K
V
G
I
Site 96
S688
A
F
A
S
Y
F
N
S
K
V
G
I
P
Q
E
Site 97
S723
K
P
A
P
R
Q
V
S
L
P
V
T
K
S
T
Site 98
T727
R
Q
V
S
L
P
V
T
K
S
T
D
N
A
F
Site 99
S729
V
S
L
P
V
T
K
S
T
D
N
A
F
E
N
Site 100
T730
S
L
P
V
T
K
S
T
D
N
A
F
E
N
P
Site 101
S742
E
N
P
F
F
K
D
S
F
G
S
S
Q
A
S
Site 102
S745
F
F
K
D
S
F
G
S
S
Q
A
S
V
A
S
Site 103
S746
F
K
D
S
F
G
S
S
Q
A
S
V
A
S
S
Site 104
S749
S
F
G
S
S
Q
A
S
V
A
S
S
Q
P
V
Site 105
S752
S
S
Q
A
S
V
A
S
S
Q
P
V
S
S
E
Site 106
S753
S
Q
A
S
V
A
S
S
Q
P
V
S
S
E
M
Site 107
S757
V
A
S
S
Q
P
V
S
S
E
M
Y
R
D
P
Site 108
S758
A
S
S
Q
P
V
S
S
E
M
Y
R
D
P
F
Site 109
Y761
Q
P
V
S
S
E
M
Y
R
D
P
F
G
N
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation