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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SRPK2
Full Name:
Serine/threonine-protein kinase SRPK2
Alias:
EC 2.7.11.1; Serine/arginine-rich protein-specific kinase 2; Serine/threonine-protein kinase SRPK2; SFRS protein kinase 2; SFRSK2; SR-protein-specific kinase 2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; SRPK family
Mass (Da):
77543
Number AA:
688
UniProt ID:
P78362
International Prot ID:
IPI00333420
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0006468
GO:0007243
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/arginine-rich protein-specific kinase 2; Serine kinase SRPK2 pan-specific antibody AB-NK296-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK296-1#Serine/arginine-rich protein-specific kinase 2 / Serine kinase SRPK2 (G343-K361, human) peptide - Powder PE-01BFI85T#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFI85T#Serine/arginine-rich protein-specific kinase 2 / Serine kinase SRPK2 (D316-E322, human) pY319 phosphopeptide - Powder PE-04APS90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APS90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
V
N
S
E
K
S
S
S
S
E
Site 2
S8
M
S
V
N
S
E
K
S
S
S
S
E
R
P
E
Site 3
S9
S
V
N
S
E
K
S
S
S
S
E
R
P
E
P
Site 4
S10
V
N
S
E
K
S
S
S
S
E
R
P
E
P
Q
Site 5
S11
N
S
E
K
S
S
S
S
E
R
P
E
P
Q
Q
Site 6
T41
P
P
P
L
P
D
P
T
P
P
E
P
E
E
E
Site 7
S52
P
E
E
E
I
L
G
S
D
D
E
E
Q
E
D
Site 8
Y63
E
Q
E
D
P
A
D
Y
C
K
G
G
Y
H
P
Site 9
Y68
A
D
Y
C
K
G
G
Y
H
P
V
K
I
G
D
Site 10
Y81
G
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
Site 11
S114
V
A
M
K
V
V
K
S
A
Q
H
Y
T
E
T
Site 12
Y118
V
V
K
S
A
Q
H
Y
T
E
T
A
L
D
E
Site 13
S135
L
L
K
C
V
R
E
S
D
P
S
D
P
N
K
Site 14
S138
C
V
R
E
S
D
P
S
D
P
N
K
D
M
V
Site 15
Y182
K
W
I
I
K
S
N
Y
Q
G
L
P
V
R
C
Site 16
Y203
Q
V
L
Q
G
L
D
Y
L
H
S
K
C
K
I
Site 17
S248
K
A
G
A
P
P
P
S
G
S
A
V
S
T
A
Site 18
S250
G
A
P
P
P
S
G
S
A
V
S
T
A
P
Q
Site 19
S253
P
P
S
G
S
A
V
S
T
A
P
Q
Q
K
P
Site 20
T254
P
S
G
S
A
V
S
T
A
P
Q
Q
K
P
I
Site 21
S265
Q
K
P
I
G
K
I
S
K
N
K
K
K
K
L
Site 22
T307
K
I
I
E
E
N
I
T
S
A
A
P
S
N
D
Site 23
S308
I
I
E
E
N
I
T
S
A
A
P
S
N
D
Q
Site 24
S312
N
I
T
S
A
A
P
S
N
D
Q
D
G
E
Y
Site 25
Y319
S
N
D
Q
D
G
E
Y
C
P
E
V
K
L
K
Serine/arginine-rich protein-specific kinase 2 / Serine kinase SRPK2 (D316-E322, human) pY319 phosphopeptide - Powder PE-04APS90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APS90
Site 26
T376
E
L
A
N
I
D
P
T
W
I
E
S
P
K
T
Site 27
S380
I
D
P
T
W
I
E
S
P
K
T
N
G
H
I
Site 28
T383
T
W
I
E
S
P
K
T
N
G
H
I
E
N
G
Site 29
S393
H
I
E
N
G
P
F
S
L
E
Q
Q
L
D
D
Site 30
Y414
D
C
P
N
P
E
E
Y
N
L
D
E
P
N
A
Site 31
S423
L
D
E
P
N
A
E
S
D
Y
T
Y
S
S
S
Site 32
Y425
E
P
N
A
E
S
D
Y
T
Y
S
S
S
Y
E
Site 33
T426
P
N
A
E
S
D
Y
T
Y
S
S
S
Y
E
Q
Site 34
Y427
N
A
E
S
D
Y
T
Y
S
S
S
Y
E
Q
F
Site 35
S429
E
S
D
Y
T
Y
S
S
S
Y
E
Q
F
N
G
Site 36
S430
S
D
Y
T
Y
S
S
S
Y
E
Q
F
N
G
E
Site 37
Y431
D
Y
T
Y
S
S
S
Y
E
Q
F
N
G
E
L
Site 38
S448
G
R
H
K
I
P
E
S
Q
F
P
E
F
S
T
Site 39
S454
E
S
Q
F
P
E
F
S
T
S
L
F
S
G
S
Site 40
T455
S
Q
F
P
E
F
S
T
S
L
F
S
G
S
L
Site 41
S456
Q
F
P
E
F
S
T
S
L
F
S
G
S
L
E
Site 42
S472
V
A
C
G
S
V
L
S
E
G
S
P
L
T
E
Site 43
S475
G
S
V
L
S
E
G
S
P
L
T
E
Q
E
E
Site 44
T478
L
S
E
G
S
P
L
T
E
Q
E
E
S
S
P
Site 45
S483
P
L
T
E
Q
E
E
S
S
P
S
H
D
R
S
Site 46
S484
L
T
E
Q
E
E
S
S
P
S
H
D
R
S
R
Site 47
S486
E
Q
E
E
S
S
P
S
H
D
R
S
R
T
V
Site 48
S490
S
S
P
S
H
D
R
S
R
T
V
S
A
S
S
Site 49
T492
P
S
H
D
R
S
R
T
V
S
A
S
S
T
G
Site 50
S494
H
D
R
S
R
T
V
S
A
S
S
T
G
D
L
Site 51
S496
R
S
R
T
V
S
A
S
S
T
G
D
L
P
K
Site 52
S497
S
R
T
V
S
A
S
S
T
G
D
L
P
K
A
Site 53
T498
R
T
V
S
A
S
S
T
G
D
L
P
K
A
K
Site 54
T506
G
D
L
P
K
A
K
T
R
A
A
D
L
L
V
Site 55
T547
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
Site 56
Y550
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
Site 57
S552
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
A
Site 58
Y582
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
Site 59
S588
D
Y
L
F
E
P
H
S
G
E
D
Y
S
R
D
Site 60
Y592
E
P
H
S
G
E
D
Y
S
R
D
E
D
H
I
Site 61
S593
P
H
S
G
E
D
Y
S
R
D
E
D
H
I
A
Site 62
S616
I
P
R
H
F
A
L
S
G
K
Y
S
R
E
F
Site 63
Y619
H
F
A
L
S
G
K
Y
S
R
E
F
F
N
R
Site 64
S620
F
A
L
S
G
K
Y
S
R
E
F
F
N
R
R
Site 65
T634
R
G
E
L
R
H
I
T
K
L
K
P
W
S
L
Site 66
Y649
F
D
V
L
V
E
K
Y
G
W
P
H
E
D
A
Site 67
S676
M
V
P
E
K
R
A
S
A
G
C
L
C
R
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation