KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PIP4K2B
Full Name:
Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
Alias:
Diphosphoinositide kinase 2-beta; EC 2.7.1.149; EC 2.7.1.68; Phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI42B; PIP5KIIB; PIP5KIIbeta; PIP5KII-beta
Type:
Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.68; EC 2.7.1.149
Mass (Da):
47378
Number AA:
416
UniProt ID:
P78356
International Prot ID:
IPI00216470
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0016308
GO:0016309
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
GO:0007166
GO:0046488
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
A
V
A
V
A
P
L
S
A
S
K
T
K
T
K
Site 2
S19
A
V
A
P
L
S
A
S
K
T
K
T
K
K
K
Site 3
T21
A
P
L
S
A
S
K
T
K
T
K
K
K
H
F
Site 4
T23
L
S
A
S
K
T
K
T
K
K
K
H
F
V
C
Site 5
S58
N
H
T
I
N
E
L
S
N
V
P
V
P
V
M
Site 6
S91
F
N
K
E
N
L
P
S
R
F
K
F
K
E
Y
Site 7
Y98
S
R
F
K
F
K
E
Y
C
P
M
V
F
R
N
Site 8
Y117
F
G
I
D
D
Q
D
Y
Q
N
S
V
T
R
S
Site 9
S120
D
D
Q
D
Y
Q
N
S
V
T
R
S
A
P
I
Site 10
S124
Y
Q
N
S
V
T
R
S
A
P
I
N
S
D
S
Site 11
S129
T
R
S
A
P
I
N
S
D
S
Q
G
R
C
G
Site 12
S131
S
A
P
I
N
S
D
S
Q
G
R
C
G
T
R
Site 13
T137
D
S
Q
G
R
C
G
T
R
F
L
T
T
Y
D
Site 14
T141
R
C
G
T
R
F
L
T
T
Y
D
R
R
F
V
Site 15
Y143
G
T
R
F
L
T
T
Y
D
R
R
F
V
I
K
Site 16
T151
D
R
R
F
V
I
K
T
V
S
S
E
D
V
A
Site 17
Y167
M
H
N
I
L
K
K
Y
H
Q
F
I
V
E
C
Site 18
T196
L
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
Site 19
Y197
T
V
D
G
V
E
T
Y
M
V
V
T
R
N
V
Site 20
S206
V
V
T
R
N
V
F
S
H
R
L
T
V
H
R
Site 21
T210
N
V
F
S
H
R
L
T
V
H
R
K
Y
D
L
Site 22
Y215
R
L
T
V
H
R
K
Y
D
L
K
G
S
T
V
Site 23
S220
R
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
Site 24
T221
K
Y
D
L
K
G
S
T
V
A
R
E
A
S
D
Site 25
S227
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
Site 26
T237
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
Site 27
S256
K
L
H
V
G
E
E
S
K
K
N
F
L
E
K
Site 28
S319
V
G
G
N
L
L
C
S
Y
G
T
P
P
D
S
Site 29
Y320
G
G
N
L
L
C
S
Y
G
T
P
P
D
S
P
Site 30
T322
N
L
L
C
S
Y
G
T
P
P
D
S
P
G
N
Site 31
S326
S
Y
G
T
P
P
D
S
P
G
N
L
L
S
F
Site 32
S332
D
S
P
G
N
L
L
S
F
P
R
F
F
G
P
Site 33
S345
G
P
G
E
F
D
P
S
V
D
V
Y
A
M
K
Site 34
Y349
F
D
P
S
V
D
V
Y
A
M
K
S
H
E
S
Site 35
S353
V
D
V
Y
A
M
K
S
H
E
S
S
P
K
K
Site 36
S356
Y
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
Site 37
S357
A
M
K
S
H
E
S
S
P
K
K
E
V
Y
F
Site 38
Y363
S
S
P
K
K
E
V
Y
F
M
A
I
I
D
I
Site 39
T372
M
A
I
I
D
I
L
T
P
Y
D
T
K
K
K
Site 40
Y374
I
I
D
I
L
T
P
Y
D
T
K
K
K
A
A
Site 41
T376
D
I
L
T
P
Y
D
T
K
K
K
A
A
H
A
Site 42
T386
K
A
A
H
A
A
K
T
V
K
H
G
A
G
A
Site 43
S396
H
G
A
G
A
E
I
S
T
V
N
P
E
Q
Y
Site 44
T397
G
A
G
A
E
I
S
T
V
N
P
E
Q
Y
S
Site 45
Y403
S
T
V
N
P
E
Q
Y
S
K
R
F
N
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation