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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EEF1A1
Full Name:
Elongation factor 1-alpha 1
Alias:
EEF1A; EF11; EF1A; EF1A1; EF-1-alpha-1; EF-Tu; Elongation factor 1 A-1; Elongation factor 1-alpha 1; Elongation factor Tu; Eukaryotic translation elongation factor 1 alpha 1; LENG7
Type:
Translation protein, initiation complex
Mass (Da):
50141
Number AA:
462
UniProt ID:
P68104
International Prot ID:
IPI00396485
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005853
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006414
Phosida
TranscriptoNet
STRING
Kinexus Products
Eukaryotic elongation factor 1-alpha 1 Y141 phosphosite-specific antibody AB-PN509#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN509#Eukaryotic elongation factor 1-alpha 1 (L138-G144, human) pY141 phosphopeptide - Powder PE-04ACQ90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACQ90#Eukaryotic elongation factor 1-alpha 1 (M155-K165, human) pT158+pS162 phosphopeptide - Powder PE-04AQZ85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQZ85#Eukaryotic elongation factor 1-alpha 1 (H26-G32, human) pY29 phosphopeptide - Powder PE-04ATE00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATE00
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
G
K
E
K
T
H
I
N
I
V
V
I
Site 2
S18
V
V
I
G
H
V
D
S
G
K
S
T
T
T
G
Site 3
S21
G
H
V
D
S
G
K
S
T
T
T
G
H
L
I
Site 4
T22
H
V
D
S
G
K
S
T
T
T
G
H
L
I
Y
Site 5
T23
V
D
S
G
K
S
T
T
T
G
H
L
I
Y
K
Site 6
T24
D
S
G
K
S
T
T
T
G
H
L
I
Y
K
C
Site 7
Y29
T
T
T
G
H
L
I
Y
K
C
G
G
I
D
K
Eukaryotic elongation factor 1-alpha 1 (H26-G32, human) pY29 phosphopeptide - Powder PE-04ATE00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ATE00
Site 8
T38
C
G
G
I
D
K
R
T
I
E
K
F
E
K
E
Site 9
Y56
M
G
K
G
S
F
K
Y
A
W
V
L
D
K
L
Site 10
T72
A
E
R
E
R
G
I
T
I
D
I
S
L
W
K
Site 11
S76
R
G
I
T
I
D
I
S
L
W
K
F
E
T
S
Site 12
T82
I
S
L
W
K
F
E
T
S
K
Y
Y
V
T
I
Site 13
Y85
W
K
F
E
T
S
K
Y
Y
V
T
I
I
D
A
Site 14
Y86
K
F
E
T
S
K
Y
Y
V
T
I
I
D
A
P
Site 15
T88
E
T
S
K
Y
Y
V
T
I
I
D
A
P
G
H
Site 16
T106
I
K
N
M
I
T
G
T
S
Q
A
D
C
A
V
Site 17
S128
G
E
F
E
A
G
I
S
K
N
G
Q
T
R
E
Site 18
T133
G
I
S
K
N
G
Q
T
R
E
H
A
L
L
A
Site 19
Y141
R
E
H
A
L
L
A
Y
T
L
G
V
K
Q
L
Eukaryotic elongation factor 1-alpha 1 Y141 phosphosite-specific antibody AB-PN509#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN509#Eukaryotic elongation factor 1-alpha 1 (L138-G144, human) pY141 phosphopeptide - Powder PE-04ACQ90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACQ90
Site 20
T142
E
H
A
L
L
A
Y
T
L
G
V
K
Q
L
I
Site 21
S157
V
G
V
N
K
M
D
S
T
E
P
P
Y
S
Q
Site 22
T158
G
V
N
K
M
D
S
T
E
P
P
Y
S
Q
K
Eukaryotic elongation factor 1-alpha 1 (M155-K165, human) pT158+pS162 phosphopeptide - Powder PE-04AQZ85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQZ85
Site 23
Y162
M
D
S
T
E
P
P
Y
S
Q
K
R
Y
E
E
Site 24
S163
D
S
T
E
P
P
Y
S
Q
K
R
Y
E
E
I
Site 25
Y167
P
P
Y
S
Q
K
R
Y
E
E
I
V
K
E
V
Site 26
T176
E
I
V
K
E
V
S
T
Y
I
K
K
I
G
Y
Site 27
Y177
I
V
K
E
V
S
T
Y
I
K
K
I
G
Y
N
Site 28
T227
D
G
N
A
S
G
T
T
L
L
E
A
L
D
C
Site 29
T239
L
D
C
I
L
P
P
T
R
P
T
D
K
P
L
Site 30
T242
I
L
P
P
T
R
P
T
D
K
P
L
R
L
P
Site 31
Y254
R
L
P
L
Q
D
V
Y
K
I
G
G
I
G
T
Site 32
T261
Y
K
I
G
G
I
G
T
V
P
V
G
R
V
E
Site 33
T269
V
P
V
G
R
V
E
T
G
V
L
K
P
G
M
Site 34
T286
T
F
A
P
V
N
V
T
T
E
V
K
S
V
E
Site 35
T287
F
A
P
V
N
V
T
T
E
V
K
S
V
E
M
Site 36
S291
N
V
T
T
E
V
K
S
V
E
M
H
H
E
A
Site 37
S300
E
M
H
H
E
A
L
S
E
A
L
P
G
D
N
Site 38
S316
G
F
N
V
K
N
V
S
V
K
D
V
R
R
G
Site 39
S329
R
G
N
V
A
G
D
S
K
N
D
P
P
M
E
Site 40
Y357
P
G
Q
I
S
A
G
Y
A
P
V
L
D
C
H
Site 41
S383
K
E
K
I
D
R
R
S
G
K
K
L
E
D
G
Site 42
S396
D
G
P
K
F
L
K
S
G
D
A
A
I
V
D
Site 43
S414
G
K
P
M
C
V
E
S
F
S
D
Y
P
P
L
Site 44
S416
P
M
C
V
E
S
F
S
D
Y
P
P
L
G
R
Site 45
Y418
C
V
E
S
F
S
D
Y
P
P
L
G
R
F
A
Site 46
T432
A
V
R
D
M
R
Q
T
V
A
V
G
V
I
K
Site 47
S454
G
A
G
K
V
T
K
S
A
Q
K
A
Q
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation