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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACTG2
Full Name:
Actin, gamma-enteric smooth muscle
Alias:
ACT; ACTA3; ACTE; ACTH; Actin, gamma 2; Actin, gamma 2, Smooth muscle, enteric; Actin, Gamma-enteric smooth muscle; ACTL3; ACTSG; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin
Type:
Cytoskeletal protein
Mass (Da):
41877
Number AA:
376
UniProt ID:
P63267
International Prot ID:
IPI00025416
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
A
P
R
A
V
F
P
S
I
V
G
R
P
R
H
Site 2
S53
V
G
M
G
Q
K
D
S
Y
V
G
D
E
A
Q
Site 3
Y54
G
M
G
Q
K
D
S
Y
V
G
D
E
A
Q
S
Site 4
S61
Y
V
G
D
E
A
Q
S
K
R
G
I
L
T
L
Site 5
T67
Q
S
K
R
G
I
L
T
L
K
Y
P
I
E
H
Site 6
Y70
R
G
I
L
T
L
K
Y
P
I
E
H
G
I
I
Site 7
T78
P
I
E
H
G
I
I
T
N
W
D
D
M
E
K
Site 8
Y92
K
I
W
H
H
S
F
Y
N
E
L
R
V
A
P
Site 9
T104
V
A
P
E
E
H
P
T
L
L
T
E
A
P
L
Site 10
T107
E
E
H
P
T
L
L
T
E
A
P
L
N
P
K
Site 11
T127
M
T
Q
I
M
F
E
T
F
N
V
P
A
M
Y
Site 12
Y144
I
Q
A
V
L
S
L
Y
A
S
G
R
T
T
G
Site 13
S156
T
T
G
I
V
L
D
S
G
D
G
V
T
H
N
Site 14
Y167
V
T
H
N
V
P
I
Y
E
G
Y
A
L
P
H
Site 15
Y170
N
V
P
I
Y
E
G
Y
A
L
P
H
A
I
M
Site 16
T187
D
L
A
G
R
D
L
T
D
Y
L
M
K
I
L
Site 17
Y189
A
G
R
D
L
T
D
Y
L
M
K
I
L
T
E
Site 18
T195
D
Y
L
M
K
I
L
T
E
R
G
Y
S
F
V
Site 19
Y199
K
I
L
T
E
R
G
Y
S
F
V
T
T
A
E
Site 20
S200
I
L
T
E
R
G
Y
S
F
V
T
T
A
E
R
Site 21
T204
R
G
Y
S
F
V
T
T
A
E
R
E
I
V
R
Site 22
Y219
D
I
K
E
K
L
C
Y
V
A
L
D
F
E
N
Site 23
T230
D
F
E
N
E
M
A
T
A
A
S
S
S
S
L
Site 24
S234
E
M
A
T
A
A
S
S
S
S
L
E
K
S
Y
Site 25
S236
A
T
A
A
S
S
S
S
L
E
K
S
Y
E
L
Site 26
S240
S
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
Site 27
Y241
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Site 28
T250
L
P
D
G
Q
V
I
T
I
G
N
E
R
F
R
Site 29
T261
E
R
F
R
C
P
E
T
L
F
Q
P
S
F
I
Site 30
S266
P
E
T
L
F
Q
P
S
F
I
G
M
E
S
A
Site 31
T278
E
S
A
G
I
H
E
T
T
Y
N
S
I
M
K
Site 32
T279
S
A
G
I
H
E
T
T
Y
N
S
I
M
K
C
Site 33
Y280
A
G
I
H
E
T
T
Y
N
S
I
M
K
C
D
Site 34
S282
I
H
E
T
T
Y
N
S
I
M
K
C
D
I
D
Site 35
Y295
I
D
I
R
K
D
L
Y
A
N
N
V
L
S
G
Site 36
T304
N
N
V
L
S
G
G
T
T
M
Y
P
G
I
A
Site 37
T305
N
V
L
S
G
G
T
T
M
Y
P
G
I
A
D
Site 38
Y307
L
S
G
G
T
T
M
Y
P
G
I
A
D
R
M
Site 39
T319
D
R
M
Q
K
E
I
T
A
L
A
P
S
T
M
Site 40
S324
E
I
T
A
L
A
P
S
T
M
K
I
K
I
I
Site 41
T325
I
T
A
L
A
P
S
T
M
K
I
K
I
I
A
Site 42
Y338
I
A
P
P
E
R
K
Y
S
V
W
I
G
G
S
Site 43
S339
A
P
P
E
R
K
Y
S
V
W
I
G
G
S
I
Site 44
Y363
M
W
I
S
K
P
E
Y
D
E
A
G
P
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation