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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STXBP1
Full Name:
Syntaxin-binding protein 1
Alias:
HUNC18; Munc18-1; N- Sec1; N-Sec1; P67; RbSec1; STB1; STXB1; Syntaxin binding protein 1; UNC18; Unc-18 homolog; Unc-18-1; UNC18A; Unc-18A
Type:
Vesicle protein
Mass (Da):
67569
Number AA:
594
UniProt ID:
P61764
International Prot ID:
IPI00084828
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005739
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0017075
GO:0030347
PhosphoSite+
KinaseNET
Biological Process:
GO:0007412
GO:0032229
GO:0070527
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S70
K
R
R
E
P
L
P
S
L
E
A
V
Y
L
I
Site 2
S83
L
I
T
P
S
E
K
S
V
H
S
L
I
S
D
Site 3
S86
P
S
E
K
S
V
H
S
L
I
S
D
F
K
D
Site 4
S89
K
S
V
H
S
L
I
S
D
F
K
D
P
P
T
Site 5
T96
S
D
F
K
D
P
P
T
A
K
Y
R
A
A
H
Site 6
Y99
K
D
P
P
T
A
K
Y
R
A
A
H
V
F
F
Site 7
T107
R
A
A
H
V
F
F
T
D
S
C
P
D
A
L
Site 8
S142
I
A
F
L
P
Y
E
S
Q
V
Y
S
L
D
S
Site 9
Y145
L
P
Y
E
S
Q
V
Y
S
L
D
S
A
D
S
Site 10
S146
P
Y
E
S
Q
V
Y
S
L
D
S
A
D
S
F
Site 11
S149
S
Q
V
Y
S
L
D
S
A
D
S
F
Q
S
F
Site 12
S152
Y
S
L
D
S
A
D
S
F
Q
S
F
Y
S
P
Site 13
S155
D
S
A
D
S
F
Q
S
F
Y
S
P
H
K
A
Site 14
S158
D
S
F
Q
S
F
Y
S
P
H
K
A
Q
M
K
Site 15
Y186
L
C
A
T
L
K
E
Y
P
A
V
R
Y
R
G
Site 16
Y195
A
V
R
Y
R
G
E
Y
K
D
N
A
L
L
A
Site 17
Y212
I
Q
D
K
L
D
A
Y
K
A
D
D
P
T
M
Site 18
T218
A
Y
K
A
D
D
P
T
M
G
E
G
P
D
K
Site 19
S228
E
G
P
D
K
A
R
S
Q
L
L
I
L
D
R
Site 20
S240
L
D
R
G
F
D
P
S
S
P
V
L
H
E
L
Site 21
S241
D
R
G
F
D
P
S
S
P
V
L
H
E
L
T
Site 22
T248
S
P
V
L
H
E
L
T
F
Q
A
M
S
Y
D
Site 23
Y264
L
P
I
E
N
D
V
Y
K
Y
E
T
S
G
I
Site 24
Y266
I
E
N
D
V
Y
K
Y
E
T
S
G
I
G
E
Site 25
S300
H
K
H
I
A
E
V
S
Q
E
V
T
R
S
L
Site 26
T304
A
E
V
S
Q
E
V
T
R
S
L
K
D
F
S
Site 27
S306
V
S
Q
E
V
T
R
S
L
K
D
F
S
S
S
Site 28
S312
R
S
L
K
D
F
S
S
S
K
R
M
N
T
G
Site 29
S313
S
L
K
D
F
S
S
S
K
R
M
N
T
G
E
Site 30
T318
S
S
S
K
R
M
N
T
G
E
K
T
T
M
R
Site 31
T322
R
M
N
T
G
E
K
T
T
M
R
D
L
S
Q
Site 32
S328
K
T
T
M
R
D
L
S
Q
M
L
K
K
M
P
Site 33
Y337
M
L
K
K
M
P
Q
Y
Q
K
E
L
S
K
Y
Site 34
S342
P
Q
Y
Q
K
E
L
S
K
Y
S
T
H
L
H
Site 35
Y344
Y
Q
K
E
L
S
K
Y
S
T
H
L
H
L
A
Site 36
S345
Q
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
Site 37
T346
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Site 38
T441
P
E
D
S
E
I
I
T
N
M
A
H
L
G
V
Site 39
S454
G
V
P
I
V
T
D
S
T
L
R
R
R
S
K
Site 40
T455
V
P
I
V
T
D
S
T
L
R
R
R
S
K
P
Site 41
S460
D
S
T
L
R
R
R
S
K
P
E
R
K
E
R
Site 42
S469
P
E
R
K
E
R
I
S
E
Q
T
Y
Q
L
S
Site 43
T472
K
E
R
I
S
E
Q
T
Y
Q
L
S
R
W
T
Site 44
Y473
E
R
I
S
E
Q
T
Y
Q
L
S
R
W
T
P
Site 45
S476
S
E
Q
T
Y
Q
L
S
R
W
T
P
I
I
K
Site 46
T479
T
Y
Q
L
S
R
W
T
P
I
I
K
D
I
M
Site 47
T489
I
K
D
I
M
E
D
T
I
E
D
K
L
D
T
Site 48
Y499
D
K
L
D
T
K
H
Y
P
Y
I
S
T
R
S
Site 49
Y501
L
D
T
K
H
Y
P
Y
I
S
T
R
S
S
A
Site 50
S503
T
K
H
Y
P
Y
I
S
T
R
S
S
A
S
F
Site 51
T504
K
H
Y
P
Y
I
S
T
R
S
S
A
S
F
S
Site 52
S506
Y
P
Y
I
S
T
R
S
S
A
S
F
S
T
T
Site 53
S507
P
Y
I
S
T
R
S
S
A
S
F
S
T
T
A
Site 54
S509
I
S
T
R
S
S
A
S
F
S
T
T
A
V
S
Site 55
S511
T
R
S
S
A
S
F
S
T
T
A
V
S
A
R
Site 56
T512
R
S
S
A
S
F
S
T
T
A
V
S
A
R
Y
Site 57
T513
S
S
A
S
F
S
T
T
A
V
S
A
R
Y
G
Site 58
S533
K
A
P
G
E
Y
R
S
G
P
R
L
I
I
F
Site 59
Y554
L
N
E
M
R
C
A
Y
E
V
T
Q
A
N
G
Site 60
T574
I
G
S
T
H
I
L
T
P
Q
K
L
L
D
T
Site 61
T581
T
P
Q
K
L
L
D
T
L
K
K
L
N
K
T
Site 62
T588
T
L
K
K
L
N
K
T
D
E
E
I
S
S
_
Site 63
S593
N
K
T
D
E
E
I
S
S
_
_
_
_
_
_
Site 64
S594
K
T
D
E
E
I
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation