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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACTR3
Full Name:
Actin-related protein 3
Alias:
Actin-2; Actin-like protein 3
Type:
Cytoskeletal protein
Mass (Da):
47371
Number AA:
418
UniProt ID:
P61158
International Prot ID:
IPI00028091
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005885
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0006928
GO:0030833
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
V
V
D
C
G
T
G
Y
T
K
L
G
Y
A
G
Site 2
Y21
T
G
Y
T
K
L
G
Y
A
G
N
T
E
P
Q
Site 3
S33
E
P
Q
F
I
I
P
S
C
I
A
I
K
E
S
Site 4
T71
D
E
A
I
E
K
P
T
Y
A
T
K
W
P
I
Site 5
Y72
E
A
I
E
K
P
T
Y
A
T
K
W
P
I
R
Site 6
T74
I
E
K
P
T
Y
A
T
K
W
P
I
R
H
G
Site 7
Y100
M
E
Q
V
I
F
K
Y
L
R
A
E
P
E
D
Site 8
Y109
R
A
E
P
E
D
H
Y
F
L
L
T
E
P
P
Site 9
T113
E
D
H
Y
F
L
L
T
E
P
P
L
N
T
P
Site 10
T119
L
T
E
P
P
L
N
T
P
E
N
R
E
Y
T
Site 11
Y125
N
T
P
E
N
R
E
Y
T
A
E
I
M
F
E
Site 12
T126
T
P
E
N
R
E
Y
T
A
E
I
M
F
E
S
Site 13
T154
L
A
L
A
A
S
W
T
S
R
Q
V
G
E
R
Site 14
T162
S
R
Q
V
G
E
R
T
L
T
G
T
V
I
D
Site 15
T164
Q
V
G
E
R
T
L
T
G
T
V
I
D
S
G
Site 16
T166
G
E
R
T
L
T
G
T
V
I
D
S
G
D
G
Site 17
T175
I
D
S
G
D
G
V
T
H
V
I
P
V
A
E
Site 18
Y184
V
I
P
V
A
E
G
Y
V
I
G
S
C
I
K
Site 19
T201
P
I
A
G
R
D
I
T
Y
F
I
Q
Q
L
L
Site 20
Y202
I
A
G
R
D
I
T
Y
F
I
Q
Q
L
L
R
Site 21
S220
V
G
I
P
P
E
Q
S
L
E
T
A
K
A
V
Site 22
Y231
A
K
A
V
K
E
R
Y
S
Y
V
C
P
D
L
Site 23
S232
K
A
V
K
E
R
Y
S
Y
V
C
P
D
L
V
Site 24
Y233
A
V
K
E
R
Y
S
Y
V
C
P
D
L
V
K
Site 25
Y245
L
V
K
E
F
N
K
Y
D
T
D
G
S
K
W
Site 26
T247
K
E
F
N
K
Y
D
T
D
G
S
K
W
I
K
Site 27
Y256
G
S
K
W
I
K
Q
Y
T
G
I
N
A
I
S
Site 28
T257
S
K
W
I
K
Q
Y
T
G
I
N
A
I
S
K
Site 29
Y273
E
F
S
I
D
V
G
Y
E
R
F
L
G
P
E
Site 30
T293
E
F
A
N
P
D
F
T
Q
P
I
S
E
V
V
Site 31
Y316
I
D
V
R
R
P
L
Y
K
N
I
V
L
S
G
Site 32
T326
I
V
L
S
G
G
S
T
M
F
R
D
F
G
R
Site 33
T342
L
Q
R
D
L
K
R
T
V
D
A
R
L
K
L
Site 34
S350
V
D
A
R
L
K
L
S
E
E
L
S
G
G
R
Site 35
S354
L
K
L
S
E
E
L
S
G
G
R
L
K
P
K
Site 36
Y400
V
C
H
T
K
K
D
Y
E
E
I
G
P
S
I
Site 37
S418
N
P
V
F
G
V
M
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation