PhosphoNET

           
Protein Info 
   
Short Name:  TIRAP
Full Name:  Toll/interleukin-1 receptor domain-containing adapter protein
Alias:  Adaptor protein Wyatt; MAL; MyD88 adapter-like; MyD88 adapter-like protein; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll-interleukin 1 receptor domain-containing adapter protein; wyatt
Type:  Adapter/scaffold protein
Mass (Da):  23883
Number AA:  221
UniProt ID:  P58753
International Prot ID:  IPI00718966
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0031224  GO:0005886 Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0004888   PhosphoSite+ KinaseNET
Biological Process:  GO:0007249  GO:0006954  GO:0045087 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T5___MASSTSLPAPGS
Site 2S6__MASSTSLPAPGSR
Site 3S12TSLPAPGSRPKKPLG
Site 4T28MADWFRQTLLKKPKK
Site 5S39KPKKRPNSPESTSSD
Site 6S42KRPNSPESTSSDASQ
Site 7T43RPNSPESTSSDASQP
Site 8S44PNSPESTSSDASQPT
Site 9S45NSPESTSSDASQPTS
Site 10S48ESTSSDASQPTSQDS
Site 11T51SSDASQPTSQDSPLP
Site 12S52SDASQPTSQDSPLPP
Site 13S55SQPTSQDSPLPPSLS
Site 14S60QDSPLPPSLSSVTSP
Site 15S62SPLPPSLSSVTSPSL
Site 16S63PLPPSLSSVTSPSLP
Site 17S66PSLSSVTSPSLPPTH
Site 18S68LSSVTSPSLPPTHAS
Site 19T72TSPSLPPTHASDSGS
Site 20S75SLPPTHASDSGSSRW
Site 21S77PPTHASDSGSSRWSK
Site 22S79THASDSGSSRWSKDY
Site 23S83DSGSSRWSKDYDVCV
Site 24Y86SSRWSKDYDVCVCHS
Site 25Y106AAQDLVSYLEGSTAS
Site 26Y159LQDPWCKYQMLQALT
Site 27T166YQMLQALTEAPGAEG
Site 28Y187SGLSRAAYPPELRFM
Site 29Y195PPELRFMYYVDGRGP
Site 30Y196PELRFMYYVDGRGPD
Site 31Y216VKEAVMRYLQTLS__
Site 32T219AVMRYLQTLS_____
Site 33S221MRYLQTLS_______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation