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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MLLT4
Full Name:
Afadin
Alias:
AF6; AF-6; AFAD; ALL1 fused gene from chromosome 6 protein; Myeloid/lymphoid or mixed-lineage leukemia (trithorax) translocated to, 4
Type:
Cell adhesion protein
Mass (Da):
206804
Number AA:
1824
UniProt ID:
P55196
International Prot ID:
IPI00398718
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005912
GO:0005911
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007267
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
R
L
D
L
F
E
I
S
Q
P
T
E
D
L
E
Site 2
Y46
F
H
G
V
M
R
F
Y
F
Q
D
K
A
A
G
Site 3
S63
A
T
K
C
I
R
V
S
S
T
A
T
T
Q
D
Site 4
S64
T
K
C
I
R
V
S
S
T
A
T
T
Q
D
V
Site 5
T68
R
V
S
S
T
A
T
T
Q
D
V
I
E
T
L
Site 6
S87
R
P
D
M
R
M
L
S
S
P
K
Y
S
L
Y
Site 7
S88
P
D
M
R
M
L
S
S
P
K
Y
S
L
Y
E
Site 8
Y91
R
M
L
S
S
P
K
Y
S
L
Y
E
V
H
V
Site 9
S92
M
L
S
S
P
K
Y
S
L
Y
E
V
H
V
S
Site 10
Y94
S
S
P
K
Y
S
L
Y
E
V
H
V
S
G
E
Site 11
S99
S
L
Y
E
V
H
V
S
G
E
R
R
L
D
I
Site 12
S239
R
M
Q
E
F
R
S
S
D
G
R
P
D
S
G
Site 13
Y385
L
P
P
E
K
L
P
Y
L
V
E
L
S
P
D
Site 14
S390
L
P
Y
L
V
E
L
S
P
D
G
S
D
S
R
Site 15
S394
V
E
L
S
P
D
G
S
D
S
R
D
K
P
K
Site 16
S396
L
S
P
D
G
S
D
S
R
D
K
P
K
L
Y
Site 17
S549
D
R
V
S
S
A
S
S
T
A
E
R
G
M
V
Site 18
S595
S
I
E
F
R
E
S
S
E
D
S
F
L
S
A
Site 19
S610
I
I
N
Y
T
N
S
S
T
V
H
F
K
L
S
Site 20
S1126
T
Q
N
G
S
P
E
S
P
Q
L
P
W
A
E
Site 21
S1135
Q
L
P
W
A
E
Y
S
E
P
K
K
L
P
G
Site 22
S1182
G
T
T
A
K
I
T
S
V
S
T
G
N
L
C
Site 23
T1194
N
L
C
T
E
E
Q
T
P
P
P
R
P
E
A
Site 24
S1300
S
S
L
D
S
S
T
S
S
Q
E
H
L
N
H
Site 25
S1309
Q
E
H
L
N
H
S
S
K
S
V
T
P
A
S
Site 26
S1311
H
L
N
H
S
S
K
S
V
T
P
A
S
T
L
Site 27
T1345
A
V
S
Q
P
I
R
T
D
L
P
P
P
P
P
Site 28
S1537
P
D
R
S
A
E
E
S
D
R
L
R
K
L
M
Site 29
S1696
P
P
P
Q
R
N
A
S
Y
L
K
T
Q
V
L
Site 30
S1726
E
E
E
E
E
D
C
S
L
A
G
Q
D
K
Y
Site 31
S1734
L
A
G
Q
D
K
Y
S
S
T
R
K
S
H
G
Site 32
S1735
A
G
Q
D
K
Y
S
S
T
R
K
S
H
G
D
Site 33
S1739
K
Y
S
S
T
R
K
S
H
G
D
L
L
P
A
Site 34
S1761
P
C
Q
P
R
P
A
S
D
G
V
F
L
S
N
Site 35
S1767
A
S
D
G
V
F
L
S
N
S
F
Q
P
P
S
Site 36
S1769
D
G
V
F
L
S
N
S
F
Q
P
P
S
A
K
Site 37
S1774
S
N
S
F
Q
P
P
S
A
K
A
N
S
T
A
Site 38
S1779
P
P
S
A
K
A
N
S
T
A
H
K
K
G
Q
Site 39
S1794
P
L
P
P
P
K
K
S
S
S
Y
H
P
S
H
Site 40
S1795
L
P
P
P
K
K
S
S
S
Y
H
P
S
H
C
Site 41
S1796
P
P
P
K
K
S
S
S
Y
H
P
S
H
C
K
Site 42
S1800
K
S
S
S
Y
H
P
S
H
C
K
G
R
G
K
Site 43
T1810
K
G
R
G
K
R
V
T
N
Q
L
S
L
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation