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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
eIF5
Full Name:
Eukaryotic translation initiation factor 5
Alias:
IF5
Type:
Protein synthesis protein, translation
Mass (Da):
49223
Number AA:
431
UniProt ID:
P55010
International Prot ID:
IPI00022648
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005829
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006446
GO:0006413
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
V
N
V
N
R
S
V
S
D
Q
F
Y
R
Site 2
S10
V
N
V
N
R
S
V
S
D
Q
F
Y
R
Y
K
Site 3
Y14
R
S
V
S
D
Q
F
Y
R
Y
K
M
P
R
L
Site 4
Y16
V
S
D
Q
F
Y
R
Y
K
M
P
R
L
I
A
Site 5
T51
K
A
L
N
R
P
P
T
Y
P
T
K
Y
F
G
Site 6
Y52
A
L
N
R
P
P
T
Y
P
T
K
Y
F
G
C
Site 7
Y56
P
P
T
Y
P
T
K
Y
F
G
C
E
L
G
A
Site 8
Y74
F
D
V
K
N
D
R
Y
I
V
N
G
S
H
E
Site 9
T107
P
E
C
E
N
P
E
T
D
L
H
V
N
P
K
Site 10
T139
D
T
H
H
K
L
C
T
F
I
L
K
N
P
P
Site 11
S149
L
K
N
P
P
E
N
S
D
S
G
T
G
K
K
Site 12
S151
N
P
P
E
N
S
D
S
G
T
G
K
K
E
K
Site 13
T153
P
E
N
S
D
S
G
T
G
K
K
E
K
E
K
Site 14
S172
G
K
D
K
E
N
G
S
V
S
S
S
E
T
P
Site 15
S174
D
K
E
N
G
S
V
S
S
S
E
T
P
P
P
Site 16
S175
K
E
N
G
S
V
S
S
S
E
T
P
P
P
P
Site 17
S176
E
N
G
S
V
S
S
S
E
T
P
P
P
P
P
Site 18
T178
G
S
V
S
S
S
E
T
P
P
P
P
P
P
P
Site 19
T207
D
D
D
W
G
E
D
T
T
E
E
A
Q
R
R
Site 20
T208
D
D
W
G
E
D
T
T
E
E
A
Q
R
R
R
Site 21
S220
R
R
R
M
D
E
I
S
D
H
A
K
V
L
T
Site 22
T227
S
D
H
A
K
V
L
T
L
S
D
D
L
E
R
Site 23
S229
H
A
K
V
L
T
L
S
D
D
L
E
R
T
I
Site 24
S258
K
E
E
G
V
I
D
S
S
D
K
E
I
V
A
Site 25
S259
E
E
G
V
I
D
S
S
D
K
E
I
V
A
E
Site 26
Y296
I
R
E
Q
I
K
K
Y
R
R
H
F
L
R
F
Site 27
Y313
N
N
K
K
A
Q
R
Y
L
L
H
G
L
E
C
Site 28
Y341
P
H
I
L
K
E
M
Y
D
A
D
L
L
E
E
Site 29
S353
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Site 30
S355
E
E
V
I
I
S
W
S
E
K
A
S
K
K
Y
Site 31
S359
I
S
W
S
E
K
A
S
K
K
Y
V
S
K
E
Site 32
Y362
S
E
K
A
S
K
K
Y
V
S
K
E
L
A
K
Site 33
S389
L
K
E
A
E
E
E
S
S
G
G
E
E
E
D
Site 34
S390
K
E
A
E
E
E
S
S
G
G
E
E
E
D
E
Site 35
Y405
D
E
N
I
E
V
V
Y
S
K
A
A
S
V
P
Site 36
S406
E
N
I
E
V
V
Y
S
K
A
A
S
V
P
K
Site 37
S410
V
V
Y
S
K
A
A
S
V
P
K
V
E
T
V
Site 38
S419
P
K
V
E
T
V
K
S
D
N
K
D
D
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation