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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE1A
Full Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Alias:
61 kDa Cam-PDE;hCam-1
Type:
Phosphodiesterase, cyclic nucleotide
Mass (Da):
61121
Number AA:
534
UniProt ID:
P54750
International Prot ID:
IPI00008282
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0004117
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
E
I
E
E
L
E
N
T
T
F
K
Y
L
T
G
Site 2
Y18
L
E
N
T
T
F
K
Y
L
T
G
E
Q
T
E
Site 3
T71
E
A
V
Y
I
D
E
T
R
R
L
L
D
T
E
Site 4
T77
E
T
R
R
L
L
D
T
E
D
E
L
S
D
I
Site 5
S82
L
D
T
E
D
E
L
S
D
I
Q
T
D
S
V
Site 6
T86
D
E
L
S
D
I
Q
T
D
S
V
P
S
E
V
Site 7
S88
L
S
D
I
Q
T
D
S
V
P
S
E
V
R
D
Site 8
S99
E
V
R
D
W
L
A
S
T
F
T
R
K
M
G
Site 9
T100
V
R
D
W
L
A
S
T
F
T
R
K
M
G
M
Site 10
S120
E
E
K
P
K
F
R
S
I
V
H
A
V
Q
A
Site 11
Y135
G
I
F
V
E
R
M
Y
R
K
T
Y
H
M
V
Site 12
T138
V
E
R
M
Y
R
K
T
Y
H
M
V
G
L
A
Site 13
Y139
E
R
M
Y
R
K
T
Y
H
M
V
G
L
A
Y
Site 14
S171
V
F
A
L
N
E
A
S
G
E
H
S
L
K
F
Site 15
S175
N
E
A
S
G
E
H
S
L
K
F
M
I
Y
E
Site 16
Y181
H
S
L
K
F
M
I
Y
E
L
F
T
R
Y
D
Site 17
T185
F
M
I
Y
E
L
F
T
R
Y
D
L
I
N
R
Site 18
S212
E
A
L
E
V
G
Y
S
K
Y
K
N
P
Y
H
Site 19
Y214
L
E
V
G
Y
S
K
Y
K
N
P
Y
H
N
L
Site 20
Y261
F
A
A
A
I
H
D
Y
E
H
T
G
T
T
N
Site 21
Y282
R
S
D
V
A
I
L
Y
N
D
R
S
V
L
E
Site 22
S286
A
I
L
Y
N
D
R
S
V
L
E
N
H
H
V
Site 23
S345
Q
I
K
N
I
R
N
S
L
Q
Q
P
E
G
I
Site 24
S368
I
L
H
A
A
D
I
S
H
P
A
K
S
W
K
Site 25
S403
A
E
L
G
L
P
F
S
P
L
C
D
R
K
S
Site 26
S410
S
P
L
C
D
R
K
S
T
M
V
A
Q
S
Q
Site 27
T411
P
L
C
D
R
K
S
T
M
V
A
Q
S
Q
I
Site 28
S416
K
S
T
M
V
A
Q
S
Q
I
G
F
I
D
F
Site 29
S448
I
P
L
I
E
E
A
S
K
A
E
T
S
S
Y
Site 30
T452
E
E
A
S
K
A
E
T
S
S
Y
V
A
S
S
Site 31
S454
A
S
K
A
E
T
S
S
Y
V
A
S
S
S
T
Site 32
Y455
S
K
A
E
T
S
S
Y
V
A
S
S
S
T
T
Site 33
S458
E
T
S
S
Y
V
A
S
S
S
T
T
I
V
G
Site 34
S475
I
A
D
A
L
R
R
S
N
T
K
G
S
M
S
Site 35
T477
D
A
L
R
R
S
N
T
K
G
S
M
S
D
G
Site 36
S480
R
R
S
N
T
K
G
S
M
S
D
G
S
Y
S
Site 37
S482
S
N
T
K
G
S
M
S
D
G
S
Y
S
P
D
Site 38
S485
K
G
S
M
S
D
G
S
Y
S
P
D
Y
S
L
Site 39
Y486
G
S
M
S
D
G
S
Y
S
P
D
Y
S
L
A
Site 40
S487
S
M
S
D
G
S
Y
S
P
D
Y
S
L
A
A
Site 41
Y490
D
G
S
Y
S
P
D
Y
S
L
A
A
V
D
L
Site 42
S491
G
S
Y
S
P
D
Y
S
L
A
A
V
D
L
K
Site 43
S526
A
A
Q
E
A
R
T
S
S
Q
K
C
E
F
I
Site 44
S527
A
Q
E
A
R
T
S
S
Q
K
C
E
F
I
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation