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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LIMK2
Full Name:
LIM domain kinase 2
Alias:
EC 2.7.11.1
Type:
Protein-serine kinase, TKL group, LISK family, LIMK subfamily
Mass (Da):
72232
Number AA:
638
UniProt ID:
P53671
International Prot ID:
IPI00022872
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
I
A
P
S
Q
I
W
Y
R
T
V
N
E
T
W
Site 2
Y51
Q
D
S
L
T
N
W
Y
Y
E
K
D
G
K
L
Site 3
Y52
D
S
L
T
N
W
Y
Y
E
K
D
G
K
L
Y
Site 4
Y59
Y
E
K
D
G
K
L
Y
C
P
K
D
Y
W
G
Site 5
Y64
K
L
Y
C
P
K
D
Y
W
G
K
F
G
E
F
Site 6
Y120
L
V
Q
H
A
T
L
Y
C
G
K
C
H
N
E
Site 7
S138
A
P
M
F
E
R
L
S
T
E
S
V
Q
E
Q
Site 8
T139
P
M
F
E
R
L
S
T
E
S
V
Q
E
Q
L
Site 9
S141
F
E
R
L
S
T
E
S
V
Q
E
Q
L
P
Y
Site 10
S149
V
Q
E
Q
L
P
Y
S
V
T
L
I
S
M
P
Site 11
T151
E
Q
L
P
Y
S
V
T
L
I
S
M
P
A
T
Site 12
T158
T
L
I
S
M
P
A
T
T
E
G
R
R
G
F
Site 13
S166
T
E
G
R
R
G
F
S
V
S
V
E
S
A
C
Site 14
S168
G
R
R
G
F
S
V
S
V
E
S
A
C
S
N
Site 15
T178
S
A
C
S
N
Y
A
T
T
V
Q
V
K
E
V
Site 16
T179
A
C
S
N
Y
A
T
T
V
Q
V
K
E
V
N
Site 17
S191
E
V
N
R
M
H
I
S
P
N
N
R
N
A
I
Site 18
T210
R
I
L
E
I
N
G
T
P
V
R
T
L
R
V
Site 19
S225
E
E
V
E
D
A
I
S
Q
T
S
Q
T
L
Q
Site 20
S241
L
I
E
H
D
P
V
S
Q
R
L
D
Q
L
R
Site 21
T271
H
A
L
S
T
L
D
T
K
E
N
L
E
G
T
Site 22
T278
T
K
E
N
L
E
G
T
L
R
R
R
S
L
R
Site 23
S283
E
G
T
L
R
R
R
S
L
R
R
S
N
S
I
Site 24
S287
R
R
R
S
L
R
R
S
N
S
I
S
K
S
P
Site 25
S289
R
S
L
R
R
S
N
S
I
S
K
S
P
G
P
Site 26
S291
L
R
R
S
N
S
I
S
K
S
P
G
P
S
S
Site 27
S293
R
S
N
S
I
S
K
S
P
G
P
S
S
P
K
Site 28
S297
I
S
K
S
P
G
P
S
S
P
K
E
P
L
L
Site 29
S298
S
K
S
P
G
P
S
S
P
K
E
P
L
L
F
Site 30
S306
P
K
E
P
L
L
F
S
R
D
I
S
R
S
E
Site 31
S310
L
L
F
S
R
D
I
S
R
S
E
S
L
R
C
Site 32
S312
F
S
R
D
I
S
R
S
E
S
L
R
C
S
S
Site 33
S314
R
D
I
S
R
S
E
S
L
R
C
S
S
S
Y
Site 34
S318
R
S
E
S
L
R
C
S
S
S
Y
S
Q
Q
I
Site 35
S319
S
E
S
L
R
C
S
S
S
Y
S
Q
Q
I
F
Site 36
S320
E
S
L
R
C
S
S
S
Y
S
Q
Q
I
F
R
Site 37
Y321
S
L
R
C
S
S
S
Y
S
Q
Q
I
F
R
P
Site 38
S322
L
R
C
S
S
S
Y
S
Q
Q
I
F
R
P
C
Site 39
T369
L
I
R
C
D
E
E
T
Q
K
T
F
L
T
E
Site 40
T372
C
D
E
E
T
Q
K
T
F
L
T
E
V
K
V
Site 41
T375
E
T
Q
K
T
F
L
T
E
V
K
V
M
R
S
Site 42
Y407
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
Site 43
S419
T
L
K
D
F
L
R
S
M
D
P
F
P
W
Q
Site 44
T490
A
P
M
E
K
A
T
T
K
K
R
T
L
R
K
Site 45
T494
K
A
T
T
K
K
R
T
L
R
K
N
D
R
K
Site 46
Y504
K
N
D
R
K
K
R
Y
T
V
V
G
N
P
Y
Site 47
T505
N
D
R
K
K
R
Y
T
V
V
G
N
P
Y
W
Site 48
S522
P
E
M
L
N
G
K
S
Y
D
E
T
V
D
I
Site 49
Y523
E
M
L
N
G
K
S
Y
D
E
T
V
D
I
F
Site 50
T526
N
G
K
S
Y
D
E
T
V
D
I
F
S
F
G
Site 51
T553
D
P
D
C
L
P
R
T
L
D
F
G
L
N
V
Site 52
S590
C
C
R
L
E
P
E
S
R
P
A
F
S
K
L
Site 53
S600
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
Site 54
S605
E
D
S
F
E
A
L
S
L
Y
L
G
E
L
G
Site 55
T625
E
L
E
E
L
D
H
T
V
S
M
Q
Y
G
L
Site 56
S627
E
E
L
D
H
T
V
S
M
Q
Y
G
L
T
R
Site 57
T633
V
S
M
Q
Y
G
L
T
R
D
S
P
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation