KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LIMK1
Full Name:
LIM domain kinase 1
Alias:
EC 2.7.11.1; Kinase LIMK1; KIZ-1; LIMK; LIMK-1
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; LISK family; LIMK subfamily
Mass (Da):
72585
Number AA:
647
UniProt ID:
P53667
International Prot ID:
IPI00291702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
GO:0030036
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
LIM domain kinase 1 T508 phosphosite-specific antibody AB-PK681#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK681#LIM domain kinase 1 (K505-G511, human) pT508 phosphopeptide - Powder PE-04ANI99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANI99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
E
R
M
G
E
E
G
S
E
L
P
V
C
A
S
Site 2
S27
S
E
L
P
V
C
A
S
C
G
Q
R
I
Y
D
Site 3
Y33
A
S
C
G
Q
R
I
Y
D
G
Q
Y
L
Q
A
Site 4
Y37
Q
R
I
Y
D
G
Q
Y
L
Q
A
L
N
A
D
Site 5
Y63
S
A
S
L
S
H
Q
Y
Y
E
K
D
G
Q
L
Site 6
Y64
A
S
L
S
H
Q
Y
Y
E
K
D
G
Q
L
F
Site 7
Y76
Q
L
F
C
K
K
D
Y
W
A
R
Y
G
E
S
Site 8
Y80
K
K
D
Y
W
A
R
Y
G
E
S
C
H
G
C
Site 9
T123
T
F
I
G
D
G
D
T
Y
T
L
V
E
H
S
Site 10
Y124
F
I
G
D
G
D
T
Y
T
L
V
E
H
S
K
Site 11
T125
I
G
D
G
D
T
Y
T
L
V
E
H
S
K
L
Site 12
Y133
L
V
E
H
S
K
L
Y
C
G
H
C
Y
Y
Q
Site 13
S154
I
E
Q
I
L
P
D
S
P
G
S
H
L
P
H
Site 14
S157
I
L
P
D
S
P
G
S
H
L
P
H
T
V
T
Site 15
S171
T
L
V
S
I
P
A
S
S
H
G
K
R
G
L
Site 16
S172
L
V
S
I
P
A
S
S
H
G
K
R
G
L
S
Site 17
S179
S
H
G
K
R
G
L
S
V
S
I
D
P
P
H
Site 18
S181
G
K
R
G
L
S
V
S
I
D
P
P
H
G
P
Site 19
T193
H
G
P
P
G
C
G
T
E
H
S
H
T
V
R
Site 20
S196
P
G
C
G
T
E
H
S
H
T
V
R
V
Q
G
Site 21
T198
C
G
T
E
H
S
H
T
V
R
V
Q
G
V
D
Site 22
S210
G
V
D
P
G
C
M
S
P
D
V
K
N
S
I
Site 23
T229
R
I
L
E
I
N
G
T
P
I
R
N
V
P
L
Site 24
T253
T
S
R
L
L
Q
L
T
L
E
H
D
P
H
D
Site 25
T261
L
E
H
D
P
H
D
T
L
G
H
G
L
G
P
Site 26
T270
G
H
G
L
G
P
E
T
S
P
L
S
S
P
A
Site 27
S271
H
G
L
G
P
E
T
S
P
L
S
S
P
A
Y
Site 28
S274
G
P
E
T
S
P
L
S
S
P
A
Y
T
P
S
Site 29
S275
P
E
T
S
P
L
S
S
P
A
Y
T
P
S
G
Site 30
Y278
S
P
L
S
S
P
A
Y
T
P
S
G
E
A
G
Site 31
T279
P
L
S
S
P
A
Y
T
P
S
G
E
A
G
S
Site 32
S281
S
S
P
A
Y
T
P
S
G
E
A
G
S
S
A
Site 33
S286
T
P
S
G
E
A
G
S
S
A
R
Q
K
P
V
Site 34
S287
P
S
G
E
A
G
S
S
A
R
Q
K
P
V
L
Site 35
S296
R
Q
K
P
V
L
R
S
C
S
I
D
R
S
P
Site 36
S298
K
P
V
L
R
S
C
S
I
D
R
S
P
G
A
Site 37
S302
R
S
C
S
I
D
R
S
P
G
A
G
S
L
G
Site 38
S307
D
R
S
P
G
A
G
S
L
G
S
P
A
S
Q
Site 39
S310
P
G
A
G
S
L
G
S
P
A
S
Q
R
K
D
Site 40
S313
G
S
L
G
S
P
A
S
Q
R
K
D
L
G
R
Site 41
S323
K
D
L
G
R
S
E
S
L
R
V
V
C
R
P
Site 42
S337
P
H
R
I
F
R
P
S
D
L
I
H
G
E
V
Site 43
T357
F
G
Q
A
I
K
V
T
H
R
E
T
G
E
V
Site 44
T361
I
K
V
T
H
R
E
T
G
E
V
M
V
M
K
Site 45
T377
L
I
R
F
D
E
E
T
Q
R
T
F
L
K
E
Site 46
T380
F
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
Site 47
T413
D
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
Site 48
Y415
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
Site 49
T420
T
E
Y
I
K
G
G
T
L
R
G
I
I
K
S
Site 50
S427
T
L
R
G
I
I
K
S
M
D
S
Q
Y
P
W
Site 51
S430
G
I
I
K
S
M
D
S
Q
Y
P
W
S
Q
R
Site 52
Y432
I
K
S
M
D
S
Q
Y
P
W
S
Q
R
V
S
Site 53
S435
M
D
S
Q
Y
P
W
S
Q
R
V
S
F
A
K
Site 54
S439
Y
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
Site 55
T490
R
L
M
V
D
E
K
T
Q
P
E
G
L
R
S
Site 56
S497
T
Q
P
E
G
L
R
S
L
K
K
P
D
R
K
Site 57
Y507
K
P
D
R
K
K
R
Y
T
V
V
G
N
P
Y
Site 58
T508
P
D
R
K
K
R
Y
T
V
V
G
N
P
Y
W
LIM domain kinase 1 T508 phosphosite-specific antibody AB-PK681#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK681#LIM domain kinase 1 (K505-G511, human) pT508 phosphopeptide - Powder PE-04ANI99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANI99
Site 59
S525
P
E
M
I
N
G
R
S
Y
D
E
K
V
D
V
Site 60
Y526
E
M
I
N
G
R
S
Y
D
E
K
V
D
V
F
Site 61
S534
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
Site 62
Y552
R
V
N
A
D
P
D
Y
L
P
R
T
M
D
F
Site 63
T556
D
P
D
Y
L
P
R
T
M
D
F
G
L
N
V
Site 64
Y570
V
R
G
F
L
D
R
Y
C
P
P
N
C
P
P
Site 65
S596
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
Site 66
T606
K
L
E
H
W
L
E
T
L
R
M
H
L
A
G
Site 67
T631
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
G
Site 68
Y632
D
R
G
F
W
E
T
Y
R
R
G
E
S
G
L
Site 69
S637
E
T
Y
R
R
G
E
S
G
L
P
A
H
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation