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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACLY
Full Name:
ATP-citrate synthase
Alias:
ACL; ATP citrate lyase; ATP-citrate (pro-S-)-lyase; ATP-citrate lyase; ATPCL; Citrate cleavage enzyme; CLATP; EC 2.3.3.8
Type:
Transferase; Carbohydrate Metabolism - citrate (TCA) cycle; Lyase; EC 2.3.3.8
Mass (Da):
120839
Number AA:
1101
UniProt ID:
P53396
International Prot ID:
IPI00021290
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009346
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003878
GO:0008815
PhosphoSite+
KinaseNET
Biological Process:
GO:0006200
GO:0044262
GO:0006101
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
Q
T
G
K
E
L
L
Y
K
F
I
C
T
T
S
Site 2
Y31
A
I
Q
N
R
F
K
Y
A
R
V
T
P
D
T
Site 3
T35
R
F
K
Y
A
R
V
T
P
D
T
D
W
A
R
Site 4
T38
Y
A
R
V
T
P
D
T
D
W
A
R
L
L
Q
Site 5
S52
Q
D
H
P
W
L
L
S
Q
N
L
V
V
K
P
Site 6
S83
L
T
L
D
G
V
K
S
W
L
K
P
R
L
G
Site 7
T94
P
R
L
G
Q
E
A
T
V
G
K
A
T
G
F
Site 8
S114
I
E
P
F
V
P
H
S
Q
A
E
E
F
Y
V
Site 9
Y120
H
S
Q
A
E
E
F
Y
V
C
I
Y
A
T
R
Site 10
Y124
E
E
F
Y
V
C
I
Y
A
T
R
E
G
D
Y
Site 11
Y131
Y
A
T
R
E
G
D
Y
V
L
F
H
H
E
G
Site 12
Y196
F
N
F
Y
E
D
L
Y
F
T
Y
L
E
I
N
Site 13
Y227
K
V
D
A
T
A
D
Y
I
C
K
V
K
W
G
Site 14
Y247
P
P
F
G
R
E
A
Y
P
E
E
A
Y
I
A
Site 15
Y252
E
A
Y
P
E
E
A
Y
I
A
D
L
D
A
K
Site 16
S260
I
A
D
L
D
A
K
S
G
A
S
L
K
L
T
Site 17
T267
S
G
A
S
L
K
L
T
L
L
N
P
K
G
R
Site 18
T277
N
P
K
G
R
I
W
T
M
V
A
G
G
G
A
Site 19
Y304
G
V
N
E
L
A
N
Y
G
E
Y
S
G
A
P
Site 20
S308
L
A
N
Y
G
E
Y
S
G
A
P
S
E
Q
Q
Site 21
S312
G
E
Y
S
G
A
P
S
E
Q
Q
T
Y
D
Y
Site 22
T316
G
A
P
S
E
Q
Q
T
Y
D
Y
A
K
T
I
Site 23
Y317
A
P
S
E
Q
Q
T
Y
D
Y
A
K
T
I
L
Site 24
Y319
S
E
Q
Q
T
Y
D
Y
A
K
T
I
L
S
L
Site 25
T328
K
T
I
L
S
L
M
T
R
E
K
H
P
D
G
Site 26
Y364
I
V
R
A
I
R
D
Y
Q
G
P
L
K
E
H
Site 27
T374
P
L
K
E
H
E
V
T
I
F
V
R
R
G
G
Site 28
Y384
V
R
R
G
G
P
N
Y
Q
E
G
L
R
V
M
Site 29
T430
P
I
P
N
Q
P
P
T
A
A
H
T
A
N
F
Site 30
T434
Q
P
P
T
A
A
H
T
A
N
F
L
L
N
A
Site 31
S442
A
N
F
L
L
N
A
S
G
S
T
S
T
P
A
Site 32
S444
F
L
L
N
A
S
G
S
T
S
T
P
A
P
S
Site 33
T445
L
L
N
A
S
G
S
T
S
T
P
A
P
S
R
Site 34
S446
L
N
A
S
G
S
T
S
T
P
A
P
S
R
T
Site 35
T447
N
A
S
G
S
T
S
T
P
A
P
S
R
T
A
Site 36
S451
S
T
S
T
P
A
P
S
R
T
A
S
F
S
E
Site 37
T453
S
T
P
A
P
S
R
T
A
S
F
S
E
S
R
Site 38
S455
P
A
P
S
R
T
A
S
F
S
E
S
R
A
D
Site 39
S457
P
S
R
T
A
S
F
S
E
S
R
A
D
E
V
Site 40
S459
R
T
A
S
F
S
E
S
R
A
D
E
V
A
P
Site 41
S478
K
P
A
M
P
Q
D
S
V
P
S
P
R
S
L
Site 42
S481
M
P
Q
D
S
V
P
S
P
R
S
L
Q
G
K
Site 43
S484
D
S
V
P
S
P
R
S
L
Q
G
K
S
T
T
Site 44
S489
P
R
S
L
Q
G
K
S
T
T
L
F
S
R
H
Site 45
T490
R
S
L
Q
G
K
S
T
T
L
F
S
R
H
T
Site 46
T491
S
L
Q
G
K
S
T
T
L
F
S
R
H
T
K
Site 47
S494
G
K
S
T
T
L
F
S
R
H
T
K
A
I
V
Site 48
Y517
Q
G
M
L
D
F
D
Y
V
C
S
R
D
E
P
Site 49
Y531
P
S
V
A
A
M
V
Y
P
F
T
G
D
H
K
Site 50
S577
I
N
F
A
S
L
R
S
A
Y
D
S
T
M
E
Site 51
Y579
F
A
S
L
R
S
A
Y
D
S
T
M
E
T
M
Site 52
S581
S
L
R
S
A
Y
D
S
T
M
E
T
M
N
Y
Site 53
T582
L
R
S
A
Y
D
S
T
M
E
T
M
N
Y
A
Site 54
Y588
S
T
M
E
T
M
N
Y
A
Q
I
R
T
I
A
Site 55
T593
M
N
Y
A
Q
I
R
T
I
A
I
I
A
E
G
Site 56
T619
K
A
D
Q
K
G
V
T
I
I
G
P
A
T
V
Site 57
T639
G
C
F
K
I
G
N
T
G
G
M
L
D
N
I
Site 58
S649
M
L
D
N
I
L
A
S
K
L
Y
R
P
G
S
Site 59
Y652
N
I
L
A
S
K
L
Y
R
P
G
S
V
A
Y
Site 60
S656
S
K
L
Y
R
P
G
S
V
A
Y
V
S
R
S
Site 61
Y659
Y
R
P
G
S
V
A
Y
V
S
R
S
G
G
M
Site 62
S661
P
G
S
V
A
Y
V
S
R
S
G
G
M
S
N
Site 63
S663
S
V
A
Y
V
S
R
S
G
G
M
S
N
E
L
Site 64
S667
V
S
R
S
G
G
M
S
N
E
L
N
N
I
I
Site 65
T677
L
N
N
I
I
S
R
T
T
D
G
V
Y
E
G
Site 66
T678
N
N
I
I
S
R
T
T
D
G
V
Y
E
G
V
Site 67
Y682
S
R
T
T
D
G
V
Y
E
G
V
A
I
G
G
Site 68
Y692
V
A
I
G
G
D
R
Y
P
G
S
T
F
M
D
Site 69
S695
G
G
D
R
Y
P
G
S
T
F
M
D
H
V
L
Site 70
T696
G
D
R
Y
P
G
S
T
F
M
D
H
V
L
R
Site 71
Y704
F
M
D
H
V
L
R
Y
Q
D
T
P
G
V
K
Site 72
T707
H
V
L
R
Y
Q
D
T
P
G
V
K
M
I
V
Site 73
T722
V
L
G
E
I
G
G
T
E
E
Y
K
I
C
R
Site 74
Y725
E
I
G
G
T
E
E
Y
K
I
C
R
G
I
K
Site 75
T820
A
Q
E
V
P
P
P
T
V
P
M
D
Y
S
W
Site 76
Y825
P
P
T
V
P
M
D
Y
S
W
A
R
E
L
G
Site 77
S826
P
T
V
P
M
D
Y
S
W
A
R
E
L
G
L
Site 78
S839
G
L
I
R
K
P
A
S
F
M
T
S
I
C
D
Site 79
S843
K
P
A
S
F
M
T
S
I
C
D
E
R
G
Q
Site 80
Y885
F
Q
K
R
L
P
K
Y
S
C
Q
F
I
E
M
Site 81
S905
A
D
H
G
P
A
V
S
G
A
H
N
T
I
I
Site 82
S922
R
A
G
K
D
L
V
S
S
L
T
S
G
L
L
Site 83
T930
S
L
T
S
G
L
L
T
I
G
D
R
F
G
G
Site 84
S979
G
I
G
H
R
V
K
S
I
N
N
P
D
M
R
Site 85
Y993
R
V
Q
I
L
K
D
Y
V
R
Q
H
F
P
A
Site 86
S1042
D
M
L
R
N
C
G
S
F
T
R
E
E
A
D
Site 87
Y1051
T
R
E
E
A
D
E
Y
I
D
I
G
A
L
N
Site 88
Y1073
S
M
G
F
I
G
H
Y
L
D
Q
K
R
L
K
Site 89
Y1084
K
R
L
K
Q
G
L
Y
R
H
P
W
D
D
I
Site 90
Y1093
H
P
W
D
D
I
S
Y
V
L
P
E
H
M
S
Site 91
S1100
Y
V
L
P
E
H
M
S
M
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation