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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NKX2-5
Full Name:
Homeobox protein Nkx-2.5
Alias:
Cardiac-specific homeobox;Homeobox protein CSX;Homeobox protein NK-2 homolog E
Type:
Mass (Da):
34918
Number AA:
324
UniProt ID:
P52952
International Prot ID:
IPI00006055
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0046982
GO:0010736
PhosphoSite+
KinaseNET
Biological Process:
GO:0007512
GO:0055014
GO:0060413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
P
S
P
A
L
T
P
T
P
F
S
V
K
D
I
Site 2
Y56
A
A
F
K
P
E
A
Y
A
G
P
E
A
A
A
Site 3
S78
A
E
L
G
R
A
P
S
P
A
K
C
A
S
A
Site 4
Y93
F
P
A
A
P
A
F
Y
P
R
A
Y
S
D
P
Site 5
Y97
P
A
F
Y
P
R
A
Y
S
D
P
D
P
A
K
Site 6
S98
A
F
Y
P
R
A
Y
S
D
P
D
P
A
K
D
Site 7
T125
K
A
V
E
L
E
K
T
E
A
D
N
A
E
R
Site 8
S146
R
K
P
R
V
L
F
S
Q
A
Q
V
Y
E
L
Site 9
Y162
R
R
F
K
Q
Q
R
Y
L
S
A
P
E
R
D
Site 10
S164
F
K
Q
Q
R
Y
L
S
A
P
E
R
D
Q
L
Site 11
S173
P
E
R
D
Q
L
A
S
V
L
K
L
T
S
T
Site 12
T180
S
V
L
K
L
T
S
T
Q
V
K
I
W
F
Q
Site 13
T201
K
R
Q
R
Q
D
Q
T
L
E
L
V
G
L
P
Site 14
S234
G
K
P
C
L
G
D
S
A
P
Y
A
P
A
Y
Site 15
Y241
S
A
P
Y
A
P
A
Y
G
V
G
L
N
P
Y
Site 16
Y248
Y
G
V
G
L
N
P
Y
G
Y
N
A
Y
P
A
Site 17
Y250
V
G
L
N
P
Y
G
Y
N
A
Y
P
A
Y
P
Site 18
Y253
N
P
Y
G
Y
N
A
Y
P
A
Y
P
G
Y
G
Site 19
Y256
G
Y
N
A
Y
P
A
Y
P
G
Y
G
G
A
A
Site 20
Y259
A
Y
P
A
Y
P
G
Y
G
G
A
A
C
S
P
Site 21
Y274
G
Y
S
C
T
A
A
Y
P
A
G
P
S
P
A
Site 22
S279
A
A
Y
P
A
G
P
S
P
A
Q
P
A
T
A
Site 23
T285
P
S
P
A
Q
P
A
T
A
A
A
N
N
N
F
Site 24
S305
G
D
L
N
A
V
Q
S
P
G
I
P
Q
S
N
Site 25
S311
Q
S
P
G
I
P
Q
S
N
S
G
V
S
T
L
Site 26
S313
P
G
I
P
Q
S
N
S
G
V
S
T
L
H
G
Site 27
T317
Q
S
N
S
G
V
S
T
L
H
G
I
R
A
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation