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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RSK2
Full Name:
Ribosomal protein S6 kinase alpha-3
Alias:
90 kDa ribosomal protein S6 kinase 3; EC 2.7.11.1; HU-3; Insulin-stimulated protein kinase 1; ISPK1; ISPK-1; Kinase RSK2; KS6A3; MAPKAPK1; MRX19; P90-RSK 3; Pp90RSK2; Ribosomal protein S6 kinase alpha 3; Ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RPS6KA3; RPS6KA-RS1; RSK; RSK-2; S6K-alpha 3
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; AGC group; RSK family; RSK subfamily
Mass (Da):
83736
Number AA:
740
UniProt ID:
P51812
International Prot ID:
IPI00020898
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
GO:0006468
GO:0007243
Phosida
TranscriptoNet
STRING
Kinexus Products
Ribosomal S6 protein-serine kinase 2; Ribosomal protein S6 kinase alpha-3 pan-specific antibody AB-NK165-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK165-2#Ribosomal S6 protein-serine kinase 2; Ribosomal protein S6 kinase alpha-3 pan-specific antibody AB-NK165-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK165-3#RPS6 (230-239) KinSub - 40S ribosomal protein S6 (K230-A239, human) peptide; RSK protein kinase substrate peptide - Powder PE-01ADP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADP95#Ribosomal S6 protein-serine kinase 2 / Ribosomal protein S6 kinase alpha-3 (N711-S724, human) peptide - Powder PE-01AQN85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AQN85#Ribosomal S6 protein-serine kinase 2 / Ribosomal protein S6 kinase alpha-3 (T391-Q409, human) peptide - Powder PE-01BFE85T#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFE85T
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
W
Q
K
M
A
V
E
S
P
S
D
S
A
E
N
Site 2
S19
K
M
A
V
E
S
P
S
D
S
A
E
N
G
Q
Site 3
S21
A
V
E
S
P
S
D
S
A
E
N
G
Q
Q
I
Site 4
T42
E
E
E
I
N
P
Q
T
E
E
V
S
I
K
E
Site 5
T53
S
I
K
E
I
A
I
T
H
H
V
K
E
G
H
Site 6
S66
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
Site 7
S78
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
Site 8
S91
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
Site 9
Y97
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
Site 10
T115
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
Site 11
Y135
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
Site 12
S160
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
Site 13
T166
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
Site 14
T210
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
Site 15
S215
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
Site 16
Y226
I
D
H
E
K
K
A
Y
S
F
C
G
T
V
E
Site 17
S227
D
H
E
K
K
A
Y
S
F
C
G
T
V
E
Y
Site 18
T231
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
Site 19
Y234
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
Site 20
T246
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
Site 21
T276
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
Site 22
T278
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
Site 23
S325
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
Site 24
S328
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Site 25
T329
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
Site 26
Y336
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
Site 27
T348
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Site 28
T354
A
T
G
R
P
E
D
T
F
Y
F
D
P
E
F
Site 29
Y356
G
R
P
E
D
T
F
Y
F
D
P
E
F
T
A
Site 30
T362
F
Y
F
D
P
E
F
T
A
K
T
P
K
D
S
Site 31
T365
D
P
E
F
T
A
K
T
P
K
D
S
P
G
I
Site 32
S369
T
A
K
T
P
K
D
S
P
G
I
P
P
S
A
Site 33
S375
D
S
P
G
I
P
P
S
A
N
A
H
Q
L
F
Site 34
S386
H
Q
L
F
R
G
F
S
F
V
A
I
T
S
D
Site 35
T391
G
F
S
F
V
A
I
T
S
D
D
E
S
Q
A
Site 36
S392
F
S
F
V
A
I
T
S
D
D
E
S
Q
A
T
Site 37
S396
A
I
T
S
D
D
E
S
Q
A
M
Q
T
V
G
Site 38
S415
V
Q
Q
L
H
R
N
S
I
Q
F
T
D
G
Y
Site 39
T419
H
R
N
S
I
Q
F
T
D
G
Y
E
V
K
E
Site 40
Y422
S
I
Q
F
T
D
G
Y
E
V
K
E
D
I
G
Site 41
S432
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
Site 42
Y433
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
Site 43
S456
A
V
K
I
I
D
K
S
K
R
D
P
T
E
E
Site 44
T461
D
K
S
K
R
D
P
T
E
E
I
E
I
L
L
Site 45
Y470
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
Site 46
Y483
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
Site 47
Y488
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
Site 48
Y490
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
Site 49
S512
I
L
R
Q
K
F
F
S
E
R
E
A
S
A
V
Site 50
S517
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
Site 51
T522
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
Site 52
Y529
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
Site 53
S543
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
Site 54
Y547
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
Site 55
S551
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
Site 56
S556
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
Site 57
T577
A
E
N
G
L
L
M
T
P
C
Y
T
A
N
F
Site 58
Y580
G
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
Site 59
T581
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
Site 60
Y595
E
V
L
K
R
Q
G
Y
D
A
A
C
D
I
W
Site 61
T616
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
D
Site 62
T625
F
A
N
G
P
D
D
T
P
E
E
I
L
A
R
Site 63
S639
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
Site 64
S641
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
Site 65
Y644
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
Site 66
S647
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
Site 67
S649
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
Site 68
T651
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
Site 69
T669
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
Site 70
Y688
H
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
A
Site 71
Y707
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
Site 72
S708
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
S
Site 73
S715
S
A
L
N
R
N
Q
S
P
V
L
E
P
V
G
Site 74
T725
L
E
P
V
G
R
S
T
L
A
Q
R
R
G
I
Site 75
S737
R
G
I
K
K
I
T
S
T
A
L
_
_
_
_
Site 76
T738
G
I
K
K
I
T
S
T
A
L
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation