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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAT5B
Full Name:
Signal transducer and activator of transcription 5B
Alias:
STA5B
Type:
Transcription protein
Mass (Da):
89866
Number AA:
787
UniProt ID:
P51692
International Prot ID:
IPI00103415
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0035259
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006103
GO:0060397
GO:0000255
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
L
H
Q
M
Q
A
L
Y
G
Q
H
F
P
I
E
Site 2
Y33
F
P
I
E
V
R
H
Y
L
S
Q
W
I
E
S
Site 3
Y90
L
K
I
K
L
G
H
Y
A
T
Q
L
Q
N
T
Site 4
T92
I
K
L
G
H
Y
A
T
Q
L
Q
N
T
Y
D
Site 5
Y98
A
T
Q
L
Q
N
T
Y
D
R
C
P
M
E
L
Site 6
Y114
R
C
I
R
H
I
L
Y
N
E
Q
R
L
V
R
Site 7
S127
V
R
E
A
N
N
G
S
S
P
A
G
S
L
A
Site 8
S128
R
E
A
N
N
G
S
S
P
A
G
S
L
A
D
Site 9
S132
N
G
S
S
P
A
G
S
L
A
D
A
M
S
Q
Site 10
S138
G
S
L
A
D
A
M
S
Q
K
H
L
Q
I
N
Site 11
T147
K
H
L
Q
I
N
Q
T
F
E
E
L
R
L
V
Site 12
T155
F
E
E
L
R
L
V
T
Q
D
T
E
N
E
L
Site 13
T158
L
R
L
V
T
Q
D
T
E
N
E
L
K
K
L
Site 14
Y171
K
L
Q
Q
T
Q
E
Y
F
I
I
Q
Y
Q
E
Site 15
Y176
Q
E
Y
F
I
I
Q
Y
Q
E
S
L
R
I
Q
Site 16
S193
F
G
P
L
A
Q
L
S
P
Q
E
R
L
S
R
Site 17
S199
L
S
P
Q
E
R
L
S
R
E
T
A
L
Q
Q
Site 18
T202
Q
E
R
L
S
R
E
T
A
L
Q
Q
K
Q
V
Site 19
T245
Q
L
L
R
K
Q
Q
T
I
I
L
D
D
E
L
Site 20
S271
N
G
G
P
P
E
G
S
L
D
V
L
Q
S
W
Site 21
S277
G
S
L
D
V
L
Q
S
W
C
E
K
L
A
E
Site 22
T344
Q
P
P
Q
V
L
K
T
Q
T
K
F
A
A
T
Site 23
T372
N
P
P
Q
V
K
A
T
I
I
S
E
Q
Q
A
Site 24
S375
Q
V
K
A
T
I
I
S
E
Q
Q
A
K
S
L
Site 25
S381
I
S
E
Q
Q
A
K
S
L
L
K
N
E
N
T
Site 26
T388
S
L
L
K
N
E
N
T
R
N
D
Y
S
G
E
Site 27
Y392
N
E
N
T
R
N
D
Y
S
G
E
I
L
N
N
Site 28
T411
E
Y
H
Q
A
T
G
T
L
S
A
H
F
R
N
Site 29
S413
H
Q
A
T
G
T
L
S
A
H
F
R
N
M
S
Site 30
S420
S
A
H
F
R
N
M
S
L
K
R
I
K
R
S
Site 31
S427
S
L
K
R
I
K
R
S
D
R
R
G
A
E
S
Site 32
S434
S
D
R
R
G
A
E
S
V
T
E
E
K
F
T
Site 33
T436
R
R
G
A
E
S
V
T
E
E
K
F
T
I
L
Site 34
T441
S
V
T
E
E
K
F
T
I
L
F
E
S
Q
F
Site 35
S521
K
F
K
A
E
V
Q
S
N
R
G
L
T
K
E
Site 36
T526
V
Q
S
N
R
G
L
T
K
E
N
L
V
F
L
Site 37
S541
A
Q
K
L
F
N
N
S
S
S
H
L
E
D
Y
Site 38
S542
Q
K
L
F
N
N
S
S
S
H
L
E
D
Y
S
Site 39
S543
K
L
F
N
N
S
S
S
H
L
E
D
Y
S
G
Site 40
Y548
S
S
S
H
L
E
D
Y
S
G
L
S
V
S
W
Site 41
S549
S
S
H
L
E
D
Y
S
G
L
S
V
S
W
S
Site 42
S552
L
E
D
Y
S
G
L
S
V
S
W
S
Q
F
N
Site 43
S554
D
Y
S
G
L
S
V
S
W
S
Q
F
N
R
E
Site 44
S556
S
G
L
S
V
S
W
S
Q
F
N
R
E
N
L
Site 45
T614
L
I
N
K
P
D
G
T
F
L
L
R
F
S
D
Site 46
S652
P
F
T
T
R
D
F
S
I
R
S
L
A
D
R
Site 47
S655
T
R
D
F
S
I
R
S
L
A
D
R
L
G
D
Site 48
Y665
D
R
L
G
D
L
N
Y
L
I
Y
V
F
P
D
Site 49
Y668
G
D
L
N
Y
L
I
Y
V
F
P
D
R
P
K
Site 50
Y679
D
R
P
K
D
E
V
Y
S
K
Y
Y
T
P
V
Site 51
Y682
K
D
E
V
Y
S
K
Y
Y
T
P
V
P
C
E
Site 52
Y683
D
E
V
Y
S
K
Y
Y
T
P
V
P
C
E
S
Site 53
T684
E
V
Y
S
K
Y
Y
T
P
V
P
C
E
S
A
Site 54
T692
P
V
P
C
E
S
A
T
A
K
A
V
D
G
Y
Site 55
Y699
T
A
K
A
V
D
G
Y
V
K
P
Q
I
K
Q
Site 56
S715
V
P
E
F
V
N
A
S
A
D
A
G
G
G
S
Site 57
Y725
A
G
G
G
S
A
T
Y
M
D
Q
A
P
S
P
Site 58
S731
T
Y
M
D
Q
A
P
S
P
A
V
C
P
Q
A
Site 59
Y740
A
V
C
P
Q
A
H
Y
N
M
Y
P
Q
N
P
Site 60
Y743
P
Q
A
H
Y
N
M
Y
P
Q
N
P
D
S
V
Site 61
S749
M
Y
P
Q
N
P
D
S
V
L
D
T
D
G
D
Site 62
T753
N
P
D
S
V
L
D
T
D
G
D
F
D
L
E
Site 63
T762
G
D
F
D
L
E
D
T
M
D
V
A
R
R
V
Site 64
S779
L
L
G
R
P
M
D
S
Q
W
I
P
H
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation