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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAPOLA
Full Name:
Poly(A) polymerase alpha
Alias:
PAP; PAPOA; Poly (A) polymerase alpha; Polynucleotide adenylyltransferase alpha
Type:
Transferase; RNA processing; EC 2.7.7.19
Mass (Da):
82843
Number AA:
745
UniProt ID:
P51003
International Prot ID:
IPI00384028
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003723
GO:0004652
PhosphoSite+
KinaseNET
Biological Process:
GO:0006378
GO:0000398
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
F
P
V
T
T
Q
G
S
Q
Q
T
Q
P
P
Q
Site 2
T13
T
T
Q
G
S
Q
Q
T
Q
P
P
Q
K
H
Y
Site 3
Y20
T
Q
P
P
Q
K
H
Y
G
I
T
S
P
I
S
Site 4
T23
P
Q
K
H
Y
G
I
T
S
P
I
S
L
A
A
Site 5
S24
Q
K
H
Y
G
I
T
S
P
I
S
L
A
A
P
Site 6
S27
Y
G
I
T
S
P
I
S
L
A
A
P
K
E
T
Site 7
S80
K
E
W
I
R
E
I
S
E
S
K
N
L
P
Q
Site 8
S82
W
I
R
E
I
S
E
S
K
N
L
P
Q
S
V
Site 9
S88
E
S
K
N
L
P
Q
S
V
I
E
N
V
G
G
Site 10
T99
N
V
G
G
K
I
F
T
F
G
S
Y
R
L
G
Site 11
S102
G
K
I
F
T
F
G
S
Y
R
L
G
V
H
T
Site 12
Y103
K
I
F
T
F
G
S
Y
R
L
G
V
H
T
K
Site 13
T109
S
Y
R
L
G
V
H
T
K
G
A
D
I
D
A
Site 14
S127
A
P
R
H
V
D
R
S
D
F
F
T
S
F
Y
Site 15
T131
V
D
R
S
D
F
F
T
S
F
Y
D
K
L
K
Site 16
S132
D
R
S
D
F
F
T
S
F
Y
D
K
L
K
L
Site 17
Y134
S
D
F
F
T
S
F
Y
D
K
L
K
L
Q
E
Site 18
S188
D
L
D
L
R
D
D
S
L
L
K
N
L
D
I
Site 19
T223
N
I
D
N
F
R
L
T
L
R
A
I
K
L
W
Site 20
Y237
W
A
K
R
H
N
I
Y
S
N
I
L
G
F
L
Site 21
S238
A
K
R
H
N
I
Y
S
N
I
L
G
F
L
G
Site 22
Y310
R
V
N
P
S
D
R
Y
H
L
M
P
I
I
T
Site 23
T317
Y
H
L
M
P
I
I
T
P
A
Y
P
Q
Q
N
Site 24
Y320
M
P
I
I
T
P
A
Y
P
Q
Q
N
S
T
Y
Site 25
T326
A
Y
P
Q
Q
N
S
T
Y
N
V
S
V
S
T
Site 26
Y327
Y
P
Q
Q
N
S
T
Y
N
V
S
V
S
T
R
Site 27
S354
I
T
D
E
I
L
L
S
K
A
E
W
S
K
L
Site 28
S380
H
Y
I
V
L
L
A
S
A
P
T
E
K
Q
R
Site 29
S420
L
A
H
V
N
P
Q
S
F
P
A
P
K
E
N
Site 30
T446
I
G
L
V
F
K
K
T
E
N
S
E
N
L
S
Site 31
S453
T
E
N
S
E
N
L
S
V
D
L
T
Y
D
I
Site 32
T457
E
N
L
S
V
D
L
T
Y
D
I
Q
S
F
T
Site 33
Y458
N
L
S
V
D
L
T
Y
D
I
Q
S
F
T
D
Site 34
S462
D
L
T
Y
D
I
Q
S
F
T
D
T
V
Y
R
Site 35
T466
D
I
Q
S
F
T
D
T
V
Y
R
Q
A
I
N
Site 36
Y468
Q
S
F
T
D
T
V
Y
R
Q
A
I
N
S
K
Site 37
S509
L
Q
K
K
K
K
H
S
T
E
G
V
K
L
T
Site 38
T510
Q
K
K
K
K
H
S
T
E
G
V
K
L
T
A
Site 39
T516
S
T
E
G
V
K
L
T
A
L
N
D
S
S
L
Site 40
S521
K
L
T
A
L
N
D
S
S
L
D
L
S
M
D
Site 41
S522
L
T
A
L
N
D
S
S
L
D
L
S
M
D
S
Site 42
S526
N
D
S
S
L
D
L
S
M
D
S
D
N
S
M
Site 43
S529
S
L
D
L
S
M
D
S
D
N
S
M
S
V
P
Site 44
S532
L
S
M
D
S
D
N
S
M
S
V
P
S
P
T
Site 45
S534
M
D
S
D
N
S
M
S
V
P
S
P
T
S
A
Site 46
S537
D
N
S
M
S
V
P
S
P
T
S
A
T
K
T
Site 47
S540
M
S
V
P
S
P
T
S
A
T
K
T
S
P
L
Site 48
T542
V
P
S
P
T
S
A
T
K
T
S
P
L
N
S
Site 49
T544
S
P
T
S
A
T
K
T
S
P
L
N
S
S
G
Site 50
S545
P
T
S
A
T
K
T
S
P
L
N
S
S
G
S
Site 51
S549
T
K
T
S
P
L
N
S
S
G
S
S
Q
G
R
Site 52
S550
K
T
S
P
L
N
S
S
G
S
S
Q
G
R
N
Site 53
S552
S
P
L
N
S
S
G
S
S
Q
G
R
N
S
P
Site 54
S553
P
L
N
S
S
G
S
S
Q
G
R
N
S
P
A
Site 55
S558
G
S
S
Q
G
R
N
S
P
A
P
A
V
T
A
Site 56
S583
V
S
V
P
Q
V
N
S
S
E
S
S
G
G
T
Site 57
S584
S
V
P
Q
V
N
S
S
E
S
S
G
G
T
S
Site 58
S586
P
Q
V
N
S
S
E
S
S
G
G
T
S
S
E
Site 59
S587
Q
V
N
S
S
E
S
S
G
G
T
S
S
E
S
Site 60
T590
S
S
E
S
S
G
G
T
S
S
E
S
I
P
Q
Site 61
S591
S
E
S
S
G
G
T
S
S
E
S
I
P
Q
T
Site 62
S592
E
S
S
G
G
T
S
S
E
S
I
P
Q
T
A
Site 63
S594
S
G
G
T
S
S
E
S
I
P
Q
T
A
T
Q
Site 64
T598
S
S
E
S
I
P
Q
T
A
T
Q
P
A
I
S
Site 65
T600
E
S
I
P
Q
T
A
T
Q
P
A
I
S
P
P
Site 66
S605
T
A
T
Q
P
A
I
S
P
P
P
K
P
T
V
Site 67
T611
I
S
P
P
P
K
P
T
V
S
R
V
V
S
S
Site 68
S613
P
P
P
K
P
T
V
S
R
V
V
S
S
T
R
Site 69
S617
P
T
V
S
R
V
V
S
S
T
R
L
V
N
P
Site 70
S618
T
V
S
R
V
V
S
S
T
R
L
V
N
P
P
Site 71
T619
V
S
R
V
V
S
S
T
R
L
V
N
P
P
P
Site 72
S628
L
V
N
P
P
P
R
S
S
G
N
A
A
T
S
Site 73
S629
V
N
P
P
P
R
S
S
G
N
A
A
T
S
G
Site 74
T644
N
A
A
T
K
I
P
T
P
I
V
G
V
K
R
Site 75
S653
I
V
G
V
K
R
T
S
S
P
H
K
E
E
S
Site 76
S654
V
G
V
K
R
T
S
S
P
H
K
E
E
S
P
Site 77
S660
S
S
P
H
K
E
E
S
P
K
K
T
K
T
E
Site 78
T664
K
E
E
S
P
K
K
T
K
T
E
E
D
E
T
Site 79
T666
E
S
P
K
K
T
K
T
E
E
D
E
T
S
E
Site 80
T671
T
K
T
E
E
D
E
T
S
E
D
A
N
C
L
Site 81
S672
K
T
E
E
D
E
T
S
E
D
A
N
C
L
A
Site 82
S681
D
A
N
C
L
A
L
S
G
H
D
K
T
E
A
Site 83
T686
A
L
S
G
H
D
K
T
E
A
K
E
Q
L
D
Site 84
T694
E
A
K
E
Q
L
D
T
E
T
S
T
T
Q
S
Site 85
S697
E
Q
L
D
T
E
T
S
T
T
Q
S
E
T
I
Site 86
T699
L
D
T
E
T
S
T
T
Q
S
E
T
I
Q
T
Site 87
S701
T
E
T
S
T
T
Q
S
E
T
I
Q
T
A
A
Site 88
T706
T
Q
S
E
T
I
Q
T
A
A
S
L
L
A
S
Site 89
S709
E
T
I
Q
T
A
A
S
L
L
A
S
Q
K
T
Site 90
S713
T
A
A
S
L
L
A
S
Q
K
T
S
S
T
D
Site 91
T716
S
L
L
A
S
Q
K
T
S
S
T
D
L
S
D
Site 92
S717
L
L
A
S
Q
K
T
S
S
T
D
L
S
D
I
Site 93
S718
L
A
S
Q
K
T
S
S
T
D
L
S
D
I
P
Site 94
S722
K
T
S
S
T
D
L
S
D
I
P
A
L
P
A
Site 95
S738
P
I
P
V
I
K
N
S
I
K
L
R
L
N
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation