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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNM2
Full Name:
Dynamin-2
Alias:
CMTDI1; CMTDIB; Cytoskeletal protein; DI-CMTB; Dynamin 2; Dynamin II; DYNII
Type:
G protein; Vesicle protein; Hydrolase; EC 3.6.5.5
Mass (Da):
98064
Number AA:
870
UniProt ID:
P50570
International Prot ID:
IPI00033022
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0000086
GO:0006897
GO:0043065
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
N
K
L
Q
D
A
F
S
S
I
G
Q
S
C
H
Site 2
S22
K
L
Q
D
A
F
S
S
I
G
Q
S
C
H
L
Site 3
S26
A
F
S
S
I
G
Q
S
C
H
L
D
L
P
Q
Site 4
S45
G
G
Q
S
A
G
K
S
S
V
L
E
N
F
V
Site 5
S61
R
D
F
L
P
R
G
S
G
I
V
T
R
R
P
Site 6
T65
P
R
G
S
G
I
V
T
R
R
P
L
I
L
Q
Site 7
T78
L
Q
L
I
F
S
K
T
E
H
A
E
F
L
H
Site 8
T92
H
C
K
S
K
K
F
T
D
F
D
E
V
R
Q
Site 9
T105
R
Q
E
I
E
A
E
T
D
R
V
T
G
T
N
Site 10
T109
E
A
E
T
D
R
V
T
G
T
N
K
G
I
S
Site 11
S116
T
G
T
N
K
G
I
S
P
V
P
I
N
L
R
Site 12
Y125
V
P
I
N
L
R
V
Y
S
P
H
V
L
N
L
Site 13
Y154
D
Q
P
P
D
I
E
Y
Q
I
K
D
M
I
L
Site 14
T214
L
D
L
M
D
E
G
T
D
A
R
D
V
L
E
Site 15
Y231
L
L
P
L
R
R
G
Y
I
G
V
V
N
R
S
Site 16
S238
Y
I
G
V
V
N
R
S
Q
K
D
I
E
G
K
Site 17
Y265
F
F
L
S
H
P
A
Y
R
H
M
A
D
R
M
Site 18
T274
H
M
A
D
R
M
G
T
P
H
L
Q
K
T
L
Site 19
T280
G
T
P
H
L
Q
K
T
L
N
Q
Q
L
T
N
Site 20
T286
K
T
L
N
Q
Q
L
T
N
H
I
R
E
S
L
Site 21
S292
L
T
N
H
I
R
E
S
L
P
A
L
R
S
K
Site 22
S298
E
S
L
P
A
L
R
S
K
L
Q
S
Q
L
L
Site 23
S302
A
L
R
S
K
L
Q
S
Q
L
L
S
L
E
K
Site 24
S306
K
L
Q
S
Q
L
L
S
L
E
K
E
V
E
E
Site 25
Y314
L
E
K
E
V
E
E
Y
K
N
F
R
P
D
D
Site 26
T323
N
F
R
P
D
D
P
T
R
K
T
K
A
L
L
Site 27
T326
P
D
D
P
T
R
K
T
K
A
L
L
Q
M
V
Site 28
T353
G
S
G
D
Q
V
D
T
L
E
L
S
G
G
A
Site 29
S357
Q
V
D
T
L
E
L
S
G
G
A
R
I
N
R
Site 30
S389
K
D
L
R
R
E
I
S
Y
A
I
K
N
I
H
Site 31
Y390
D
L
R
R
E
I
S
Y
A
I
K
N
I
H
G
Site 32
T438
V
I
Q
E
L
I
N
T
V
R
Q
C
T
S
K
Site 33
T443
I
N
T
V
R
Q
C
T
S
K
L
S
S
Y
P
Site 34
S444
N
T
V
R
Q
C
T
S
K
L
S
S
Y
P
R
Site 35
S447
R
Q
C
T
S
K
L
S
S
Y
P
R
L
R
E
Site 36
S448
Q
C
T
S
K
L
S
S
Y
P
R
L
R
E
E
Site 37
Y449
C
T
S
K
L
S
S
Y
P
R
L
R
E
E
T
Site 38
T456
Y
P
R
L
R
E
E
T
E
R
I
V
T
T
Y
Site 39
T461
E
E
T
E
R
I
V
T
T
Y
I
R
E
R
E
Site 40
Y463
T
E
R
I
V
T
T
Y
I
R
E
R
E
G
R
Site 41
Y485
L
I
D
I
E
Q
S
Y
I
N
T
N
H
E
D
Site 42
T504
A
N
A
Q
Q
R
S
T
Q
L
N
K
K
R
A
Site 43
T527
V
I
R
R
G
W
L
T
I
N
N
I
S
L
M
Site 44
S532
W
L
T
I
N
N
I
S
L
M
K
G
G
S
K
Site 45
T546
K
E
Y
W
F
V
L
T
A
E
S
L
S
W
Y
Site 46
S551
V
L
T
A
E
S
L
S
W
Y
K
D
E
E
E
Site 47
Y553
T
A
E
S
L
S
W
Y
K
D
E
E
E
K
E
Site 48
Y563
E
E
E
K
E
K
K
Y
M
L
P
L
D
N
L
Site 49
S581
D
V
E
K
G
F
M
S
N
K
H
V
F
A
I
Site 50
T591
H
V
F
A
I
F
N
T
E
Q
R
N
V
Y
K
Site 51
Y597
N
T
E
Q
R
N
V
Y
K
D
L
R
Q
I
E
Site 52
S609
Q
I
E
L
A
C
D
S
Q
E
D
V
D
S
W
Site 53
S615
D
S
Q
E
D
V
D
S
W
K
A
S
F
L
R
Site 54
S619
D
V
D
S
W
K
A
S
F
L
R
A
G
V
Y
Site 55
Y626
S
F
L
R
A
G
V
Y
P
E
K
D
Q
A
E
Site 56
T642
E
D
G
A
Q
E
N
T
F
S
M
D
P
Q
L
Site 57
S644
G
A
Q
E
N
T
F
S
M
D
P
Q
L
E
R
Site 58
S662
T
I
R
N
L
V
D
S
Y
V
A
I
I
N
K
Site 59
Y663
I
R
N
L
V
D
S
Y
V
A
I
I
N
K
S
Site 60
Y698
I
H
H
E
L
L
A
Y
L
Y
S
S
A
D
Q
Site 61
Y700
H
E
L
L
A
Y
L
Y
S
S
A
D
Q
S
S
Site 62
S701
E
L
L
A
Y
L
Y
S
S
A
D
Q
S
S
L
Site 63
S706
L
Y
S
S
A
D
Q
S
S
L
M
E
E
S
A
Site 64
S707
Y
S
S
A
D
Q
S
S
L
M
E
E
S
A
D
Site 65
Y726
R
D
D
M
L
R
M
Y
H
A
L
K
E
A
L
Site 66
S745
D
I
S
T
S
T
V
S
T
P
V
P
P
P
V
Site 67
T746
I
S
T
S
T
V
S
T
P
V
P
P
P
V
D
Site 68
T755
V
P
P
P
V
D
D
T
W
L
Q
S
A
S
S
Site 69
S759
V
D
D
T
W
L
Q
S
A
S
S
H
S
P
T
Site 70
S761
D
T
W
L
Q
S
A
S
S
H
S
P
T
P
Q
Site 71
S762
T
W
L
Q
S
A
S
S
H
S
P
T
P
Q
R
Site 72
S764
L
Q
S
A
S
S
H
S
P
T
P
Q
R
R
P
Site 73
T766
S
A
S
S
H
S
P
T
P
Q
R
R
P
V
S
Site 74
S773
T
P
Q
R
R
P
V
S
S
I
H
P
P
G
R
Site 75
S774
P
Q
R
R
P
V
S
S
I
H
P
P
G
R
P
Site 76
T788
P
P
A
V
R
G
P
T
P
G
P
P
L
I
P
Site 77
S811
F
S
A
P
P
I
P
S
R
P
G
P
Q
S
V
Site 78
S817
P
S
R
P
G
P
Q
S
V
F
A
N
S
D
L
Site 79
S833
P
A
P
P
Q
I
P
S
R
P
V
R
I
P
P
Site 80
S848
G
I
P
P
G
V
P
S
R
R
P
P
A
A
P
Site 81
S856
R
R
P
P
A
A
P
S
R
P
T
I
I
R
P
Site 82
T859
P
A
A
P
S
R
P
T
I
I
R
P
A
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation