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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MMP14
Full Name:
Matrix metalloproteinase-14
Alias:
EC 3.4.24.80; Matrix metallopeptidase 14 (membrane-inserted); Matrix metalloproteinase-14 precursor; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP- X1; MMP-14; MT1MMP; MT1-MMP; MT-MMP 1; MTMMP1
Type:
EC 3.4.24.80; Protease
Mass (Da):
65884
Number AA:
582
UniProt ID:
P50281
International Prot ID:
IPI00218398
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0042470
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004222
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
A
S
L
G
S
A
Q
S
S
S
F
S
P
E
A
Site 2
S31
S
L
G
S
A
Q
S
S
S
F
S
P
E
A
W
Site 3
S32
L
G
S
A
Q
S
S
S
F
S
P
E
A
W
L
Site 4
S34
S
A
Q
S
S
S
F
S
P
E
A
W
L
Q
Q
Site 5
Y42
P
E
A
W
L
Q
Q
Y
G
Y
L
P
P
G
D
Site 6
Y44
A
W
L
Q
Q
Y
G
Y
L
P
P
G
D
L
R
Site 7
T52
L
P
P
G
D
L
R
T
H
T
Q
R
S
P
Q
Site 8
T54
P
G
D
L
R
T
H
T
Q
R
S
P
Q
S
L
Site 9
S57
L
R
T
H
T
Q
R
S
P
Q
S
L
S
A
A
Site 10
S60
H
T
Q
R
S
P
Q
S
L
S
A
A
I
A
A
Site 11
S62
Q
R
S
P
Q
S
L
S
A
A
I
A
A
M
Q
Site 12
T77
K
F
Y
G
L
Q
V
T
G
K
A
D
A
D
T
Site 13
T84
T
G
K
A
D
A
D
T
M
K
A
M
R
R
P
Site 14
Y138
Y
T
P
K
V
G
E
Y
A
T
Y
E
A
I
R
Site 15
T140
P
K
V
G
E
Y
A
T
Y
E
A
I
R
K
A
Site 16
Y141
K
V
G
E
Y
A
T
Y
E
A
I
R
K
A
F
Site 17
T567
F
F
F
R
R
H
G
T
P
R
R
L
L
Y
C
Site 18
Y573
G
T
P
R
R
L
L
Y
C
Q
R
S
L
L
D
Site 19
S577
R
L
L
Y
C
Q
R
S
L
L
D
K
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation