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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TSC2
Full Name:
Tuberin
Alias:
LAM; TSC4; Tuberous sclerosis 2; Tuberous sclerosis 2 gene; Tuberous sclerosis 2 homolog protein
Type:
Tumor suppressor; Nuclear receptor co-regulator; GTPase activating protein, misc.; Cell cycle regulation
Mass (Da):
200608
Number AA:
1807
UniProt ID:
P49815
International Prot ID:
IPI00028493
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0033596
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0007507
GO:0048009
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
K
P
T
S
K
D
S
G
L
K
E
Site 2
S9
A
K
P
T
S
K
D
S
G
L
K
E
K
F
K
Site 3
T23
K
I
L
L
G
L
G
T
P
R
P
N
P
R
S
Site 4
S30
T
P
R
P
N
P
R
S
A
E
G
K
Q
T
E
Site 5
T36
R
S
A
E
G
K
Q
T
E
F
I
I
T
A
E
Site 6
S49
A
E
I
L
R
E
L
S
M
E
C
G
L
N
N
Site 7
T70
Q
I
C
E
V
A
K
T
K
K
F
E
E
H
A
Site 8
Y130
F
F
K
V
I
K
D
Y
P
S
N
E
D
L
H
Site 9
S132
K
V
I
K
D
Y
P
S
N
E
D
L
H
E
R
Site 10
T154
T
D
N
G
R
H
I
T
Y
L
E
E
E
L
A
Site 11
Y155
D
N
G
R
H
I
T
Y
L
E
E
E
L
A
D
Site 12
S188
V
N
L
V
K
F
N
S
C
Y
L
D
E
Y
I
Site 13
Y190
L
V
K
F
N
S
C
Y
L
D
E
Y
I
A
R
Site 14
Y194
N
S
C
Y
L
D
E
Y
I
A
R
M
V
Q
M
Site 15
Y285
H
L
M
E
D
R
A
Y
M
E
D
A
P
L
L
Site 16
Y310
L
W
G
A
H
R
L
Y
S
L
R
N
S
P
T
Site 17
S311
W
G
A
H
R
L
Y
S
L
R
N
S
P
T
S
Site 18
S315
R
L
Y
S
L
R
N
S
P
T
S
V
F
P
S
Site 19
T317
Y
S
L
R
N
S
P
T
S
V
F
P
S
F
Y
Site 20
S318
S
L
R
N
S
P
T
S
V
F
P
S
F
Y
Q
Site 21
Y349
I
T
R
L
I
K
K
Y
R
K
E
L
Q
V
V
Site 22
T374
R
L
L
Q
Q
L
Q
T
L
D
S
P
E
L
R
Site 23
S377
Q
Q
L
Q
T
L
D
S
P
E
L
R
T
I
V
Site 24
S403
D
Q
N
E
F
H
G
S
Q
E
R
Y
F
E
L
Site 25
Y407
F
H
G
S
Q
E
R
Y
F
E
L
V
E
R
C
Site 26
S421
C
A
D
Q
R
P
E
S
S
L
L
N
L
I
S
Site 27
S422
A
D
Q
R
P
E
S
S
L
L
N
L
I
S
Y
Site 28
S428
S
S
L
L
N
L
I
S
Y
R
A
Q
S
I
H
Site 29
Y429
S
L
L
N
L
I
S
Y
R
A
Q
S
I
H
P
Site 30
S433
L
I
S
Y
R
A
Q
S
I
H
P
A
K
D
G
Site 31
S455
L
M
E
R
F
F
R
S
E
S
R
G
A
V
R
Site 32
S457
E
R
F
F
R
S
E
S
R
G
A
V
R
I
K
Site 33
Y480
L
L
I
N
R
Q
F
Y
E
E
E
L
I
N
S
Site 34
S494
S
V
V
I
S
Q
L
S
H
I
P
E
D
K
D
Site 35
T521
D
L
A
E
G
C
H
T
H
H
F
N
S
L
L
Site 36
S538
I
E
K
V
M
A
R
S
L
S
P
P
P
E
L
Site 37
S540
K
V
M
A
R
S
L
S
P
P
P
E
L
E
E
Site 38
Y553
E
E
R
D
V
A
A
Y
S
A
S
L
E
D
V
Site 39
S581
K
L
Y
T
L
P
A
S
H
A
T
R
V
Y
E
Site 40
S601
I
Q
L
H
Y
K
H
S
Y
T
L
P
I
A
S
Site 41
Y602
Q
L
H
Y
K
H
S
Y
T
L
P
I
A
S
S
Site 42
T603
L
H
Y
K
H
S
Y
T
L
P
I
A
S
S
I
Site 43
S608
S
Y
T
L
P
I
A
S
S
I
R
L
Q
A
F
Site 44
Y648
S
P
Y
C
V
C
D
Y
M
E
P
E
R
G
S
Site 45
S655
Y
M
E
P
E
R
G
S
E
K
K
T
S
G
P
Site 46
T659
E
R
G
S
E
K
K
T
S
G
P
L
S
P
P
Site 47
S660
R
G
S
E
K
K
T
S
G
P
L
S
P
P
T
Site 48
S664
K
K
T
S
G
P
L
S
P
P
T
G
P
P
G
Site 49
T667
S
G
P
L
S
P
P
T
G
P
P
G
P
A
P
Site 50
Y719
R
L
P
E
S
L
R
Y
K
V
L
I
F
T
S
Site 51
S742
S
A
L
C
S
M
L
S
G
P
K
T
L
E
R
Site 52
T746
S
M
L
S
G
P
K
T
L
E
R
L
R
G
A
Site 53
T760
A
P
E
G
F
S
R
T
D
L
H
L
A
V
V
Site 54
Y779
A
L
I
S
Y
H
N
Y
L
D
K
T
K
Q
R
Site 55
Y790
T
K
Q
R
E
M
V
Y
C
L
E
Q
G
L
I
Site 56
Y857
L
A
R
L
P
H
L
Y
R
N
F
A
A
E
Q
Site 57
T876
F
A
I
S
L
P
Y
T
N
P
S
K
F
N
Q
Site 58
Y884
N
P
S
K
F
N
Q
Y
I
V
C
L
A
H
H
Site 59
S923
L
R
S
N
V
L
L
S
F
D
D
T
P
E
K
Site 60
T927
V
L
L
S
F
D
D
T
P
E
K
D
S
F
R
Site 61
S932
D
D
T
P
E
K
D
S
F
R
A
R
S
T
S
Site 62
S937
K
D
S
F
R
A
R
S
T
S
L
N
E
R
P
Site 63
T938
D
S
F
R
A
R
S
T
S
L
N
E
R
P
K
Site 64
S939
S
F
R
A
R
S
T
S
L
N
E
R
P
K
S
Site 65
S946
S
L
N
E
R
P
K
S
L
R
I
A
R
P
P
Site 66
S960
P
K
Q
G
L
N
N
S
P
P
V
K
E
F
K
Site 67
S979
A
E
A
F
R
C
R
S
I
S
V
S
E
H
V
Site 68
S981
A
F
R
C
R
S
I
S
V
S
E
H
V
V
R
Site 69
S983
R
C
R
S
I
S
V
S
E
H
V
V
R
S
R
Site 70
S994
V
R
S
R
I
Q
T
S
L
T
S
A
S
L
G
Site 71
T996
S
R
I
Q
T
S
L
T
S
A
S
L
G
S
A
Site 72
S997
R
I
Q
T
S
L
T
S
A
S
L
G
S
A
D
Site 73
S999
Q
T
S
L
T
S
A
S
L
G
S
A
D
E
N
Site 74
S1007
L
G
S
A
D
E
N
S
V
A
Q
A
D
D
S
Site 75
S1014
S
V
A
Q
A
D
D
S
L
K
N
L
H
L
E
Site 76
T1023
K
N
L
H
L
E
L
T
E
T
C
L
D
M
M
Site 77
T1059
L
A
G
G
R
T
K
T
W
L
V
G
N
K
L
Site 78
S1072
K
L
V
T
V
T
T
S
V
G
T
G
T
R
S
Site 79
S1079
S
V
G
T
G
T
R
S
L
L
G
L
D
S
G
Site 80
S1085
R
S
L
L
G
L
D
S
G
E
L
Q
S
G
P
Site 81
S1090
L
D
S
G
E
L
Q
S
G
P
E
S
S
S
S
Site 82
S1094
E
L
Q
S
G
P
E
S
S
S
S
P
G
V
H
Site 83
S1095
L
Q
S
G
P
E
S
S
S
S
P
G
V
H
V
Site 84
S1096
Q
S
G
P
E
S
S
S
S
P
G
V
H
V
R
Site 85
S1097
S
G
P
E
S
S
S
S
P
G
V
H
V
R
Q
Site 86
T1105
P
G
V
H
V
R
Q
T
K
E
A
P
A
K
L
Site 87
S1114
E
A
P
A
K
L
E
S
Q
A
G
Q
Q
V
S
Site 88
S1130
G
A
R
D
R
V
R
S
M
S
G
G
H
G
L
Site 89
S1132
R
D
R
V
R
S
M
S
G
G
H
G
L
R
V
Site 90
S1152
P
A
S
Q
F
L
G
S
A
T
S
P
G
P
R
Site 91
S1155
Q
F
L
G
S
A
T
S
P
G
P
R
T
A
P
Site 92
Y1186
E
K
T
N
L
A
A
Y
V
P
L
L
T
Q
G
Site 93
T1203
E
I
L
V
R
R
P
T
G
N
T
S
W
L
M
Site 94
T1206
V
R
R
P
T
G
N
T
S
W
L
M
S
L
E
Site 95
S1207
R
R
P
T
G
N
T
S
W
L
M
S
L
E
N
Site 96
S1211
G
N
T
S
W
L
M
S
L
E
N
P
L
S
P
Site 97
S1217
M
S
L
E
N
P
L
S
P
F
S
S
D
I
N
Site 98
S1220
E
N
P
L
S
P
F
S
S
D
I
N
N
M
P
Site 99
S1221
N
P
L
S
P
F
S
S
D
I
N
N
M
P
L
Site 100
T1247
R
F
K
E
H
R
D
T
A
L
Y
K
S
L
S
Site 101
Y1250
E
H
R
D
T
A
L
Y
K
S
L
S
V
P
A
Site 102
S1252
R
D
T
A
L
Y
K
S
L
S
V
P
A
A
S
Site 103
S1254
T
A
L
Y
K
S
L
S
V
P
A
A
S
T
A
Site 104
S1259
S
L
S
V
P
A
A
S
T
A
K
P
P
P
L
Site 105
S1269
K
P
P
P
L
P
R
S
N
T
V
A
S
F
S
Site 106
T1271
P
P
L
P
R
S
N
T
V
A
S
F
S
S
L
Site 107
S1274
P
R
S
N
T
V
A
S
F
S
S
L
Y
Q
S
Site 108
S1276
S
N
T
V
A
S
F
S
S
L
Y
Q
S
S
C
Site 109
S1277
N
T
V
A
S
F
S
S
L
Y
Q
S
S
C
Q
Site 110
Y1279
V
A
S
F
S
S
L
Y
Q
S
S
C
Q
G
Q
Site 111
S1281
S
F
S
S
L
Y
Q
S
S
C
Q
G
Q
L
H
Site 112
S1282
F
S
S
L
Y
Q
S
S
C
Q
G
Q
L
H
R
Site 113
S1290
C
Q
G
Q
L
H
R
S
V
S
W
A
D
S
A
Site 114
S1292
G
Q
L
H
R
S
V
S
W
A
D
S
A
V
V
Site 115
S1296
R
S
V
S
W
A
D
S
A
V
V
M
E
E
G
Site 116
T1330
A
L
G
M
D
R
R
T
D
A
Y
S
R
S
S
Site 117
Y1333
M
D
R
R
T
D
A
Y
S
R
S
S
S
V
S
Site 118
S1334
D
R
R
T
D
A
Y
S
R
S
S
S
V
S
S
Site 119
S1336
R
T
D
A
Y
S
R
S
S
S
V
S
S
Q
E
Site 120
S1337
T
D
A
Y
S
R
S
S
S
V
S
S
Q
E
E
Site 121
S1338
D
A
Y
S
R
S
S
S
V
S
S
Q
E
E
K
Site 122
S1340
Y
S
R
S
S
S
V
S
S
Q
E
E
K
S
L
Site 123
S1341
S
R
S
S
S
V
S
S
Q
E
E
K
S
L
H
Site 124
S1346
V
S
S
Q
E
E
K
S
L
H
A
E
E
L
V
Site 125
S1364
I
P
I
E
R
V
V
S
S
E
G
G
R
P
S
Site 126
S1365
P
I
E
R
V
V
S
S
E
G
G
R
P
S
V
Site 127
S1371
S
S
E
G
G
R
P
S
V
D
L
S
F
Q
P
Site 128
S1375
G
R
P
S
V
D
L
S
F
Q
P
S
Q
P
L
Site 129
S1379
V
D
L
S
F
Q
P
S
Q
P
L
S
K
S
S
Site 130
S1383
F
Q
P
S
Q
P
L
S
K
S
S
S
S
P
E
Site 131
S1385
P
S
Q
P
L
S
K
S
S
S
S
P
E
L
Q
Site 132
S1386
S
Q
P
L
S
K
S
S
S
S
P
E
L
Q
T
Site 133
S1387
Q
P
L
S
K
S
S
S
S
P
E
L
Q
T
L
Site 134
S1388
P
L
S
K
S
S
S
S
P
E
L
Q
T
L
Q
Site 135
T1393
S
S
S
P
E
L
Q
T
L
Q
D
I
L
G
D
Site 136
S1411
K
A
D
V
G
R
L
S
P
E
V
K
A
R
S
Site 137
S1418
S
P
E
V
K
A
R
S
Q
S
G
T
L
D
G
Site 138
S1420
E
V
K
A
R
S
Q
S
G
T
L
D
G
E
S
Site 139
T1422
K
A
R
S
Q
S
G
T
L
D
G
E
S
A
A
Site 140
S1427
S
G
T
L
D
G
E
S
A
A
W
S
A
S
G
Site 141
S1431
D
G
E
S
A
A
W
S
A
S
G
E
D
S
R
Site 142
S1433
E
S
A
A
W
S
A
S
G
E
D
S
R
G
Q
Site 143
S1437
W
S
A
S
G
E
D
S
R
G
Q
P
E
G
P
Site 144
S1447
Q
P
E
G
P
L
P
S
S
S
P
R
S
P
S
Site 145
S1448
P
E
G
P
L
P
S
S
S
P
R
S
P
S
G
Site 146
S1449
E
G
P
L
P
S
S
S
P
R
S
P
S
G
L
Site 147
S1452
L
P
S
S
S
P
R
S
P
S
G
L
R
P
R
Site 148
S1454
S
S
S
P
R
S
P
S
G
L
R
P
R
G
Y
Site 149
Y1461
S
G
L
R
P
R
G
Y
T
I
S
D
S
A
P
Site 150
T1462
G
L
R
P
R
G
Y
T
I
S
D
S
A
P
S
Site 151
S1464
R
P
R
G
Y
T
I
S
D
S
A
P
S
R
R
Site 152
S1466
R
G
Y
T
I
S
D
S
A
P
S
R
R
G
K
Site 153
S1469
T
I
S
D
S
A
P
S
R
R
G
K
R
V
E
Site 154
S1482
V
E
R
D
A
L
K
S
R
A
T
A
S
N
A
Site 155
T1485
D
A
L
K
S
R
A
T
A
S
N
A
E
K
V
Site 156
S1507
V
F
L
Q
L
Y
H
S
P
F
F
G
D
E
S
Site 157
S1514
S
P
F
F
G
D
E
S
N
K
P
I
L
L
P
Site 158
S1524
P
I
L
L
P
N
E
S
Q
S
F
E
R
S
V
Site 159
S1526
L
L
P
N
E
S
Q
S
F
E
R
S
V
Q
L
Site 160
S1530
E
S
Q
S
F
E
R
S
V
Q
L
L
D
Q
I
Site 161
Y1540
L
L
D
Q
I
P
S
Y
D
T
H
K
I
A
V
Site 162
Y1549
T
H
K
I
A
V
L
Y
V
G
E
G
Q
S
N
Site 163
S1557
V
G
E
G
Q
S
N
S
E
L
A
I
L
S
N
Site 164
S1563
N
S
E
L
A
I
L
S
N
E
H
G
S
Y
R
Site 165
S1568
I
L
S
N
E
H
G
S
Y
R
Y
T
E
F
L
Site 166
Y1569
L
S
N
E
H
G
S
Y
R
Y
T
E
F
L
T
Site 167
Y1571
N
E
H
G
S
Y
R
Y
T
E
F
L
T
G
L
Site 168
T1572
E
H
G
S
Y
R
Y
T
E
F
L
T
G
L
G
Site 169
Y1593
D
C
Q
P
D
K
V
Y
L
G
G
L
D
V
C
Site 170
S1647
H
L
G
N
D
F
V
S
I
V
Y
N
D
S
G
Site 171
S1653
V
S
I
V
Y
N
D
S
G
E
D
F
K
L
G
Site 172
T1697
D
M
E
G
L
V
D
T
S
V
A
K
I
V
S
Site 173
S1704
T
S
V
A
K
I
V
S
D
R
N
L
P
F
V
Site 174
S1723
A
L
H
A
N
M
A
S
Q
V
H
H
S
R
S
Site 175
S1730
S
Q
V
H
H
S
R
S
N
P
T
D
I
Y
P
Site 176
Y1736
R
S
N
P
T
D
I
Y
P
S
K
W
I
A
R
Site 177
Y1760
R
I
C
E
E
A
A
Y
S
N
P
S
L
P
L
Site 178
S1761
I
C
E
E
A
A
Y
S
N
P
S
L
P
L
V
Site 179
S1764
E
A
A
Y
S
N
P
S
L
P
L
V
H
P
P
Site 180
S1772
L
P
L
V
H
P
P
S
H
S
K
A
P
A
Q
Site 181
S1774
L
V
H
P
P
S
H
S
K
A
P
A
Q
T
P
Site 182
T1780
H
S
K
A
P
A
Q
T
P
A
E
P
T
P
G
Site 183
T1785
A
Q
T
P
A
E
P
T
P
G
Y
E
V
G
Q
Site 184
Y1788
P
A
E
P
T
P
G
Y
E
V
G
Q
R
K
R
Site 185
S1798
G
Q
R
K
R
L
I
S
S
V
E
D
F
T
E
Site 186
S1799
Q
R
K
R
L
I
S
S
V
E
D
F
T
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation