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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FHIT
Full Name:
Bis(5'-adenosyl)-triphosphatase
Alias:
AP3A hydrolase;Diadenosine 5',5'''-P1,P3-triphosphate hydrolase;Dinucleosidetriphosphatase;Fragile histidine triad protein
Type:
Tumour suppressor protein
Mass (Da):
16727
Number AA:
147
UniProt ID:
P49789
International Prot ID:
IPI00028095
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0047710
GO:0000287
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0009117
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T67
Q
T
T
Q
R
V
G
T
V
V
E
K
H
F
H
Site 2
S77
E
K
H
F
H
G
T
S
L
T
F
S
M
Q
D
Site 3
T79
H
F
H
G
T
S
L
T
F
S
M
Q
D
G
P
Site 4
S81
H
G
T
S
L
T
F
S
M
Q
D
G
P
E
A
Site 5
T91
D
G
P
E
A
G
Q
T
V
K
H
V
H
V
H
Site 6
S112
G
D
F
H
R
N
D
S
I
Y
E
E
L
Q
K
Site 7
Y114
F
H
R
N
D
S
I
Y
E
E
L
Q
K
H
D
Site 8
S128
D
K
E
D
F
P
A
S
W
R
S
E
E
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation