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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSEN1
Full Name:
Presenilin-1
Alias:
AD3; AD3H; FAD; Presenilin-1 CTF12; PS1; PS-1; PSN1; PSNL1; S182; S182 protein
Type:
Cell surface; Protease; EC 3.4.23.-
Mass (Da):
52668
Number AA:
467
UniProt ID:
P49768
International Prot ID:
IPI00028077
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0009986
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0030165
GO:0008013
GO:0004175
PhosphoSite+
KinaseNET
Biological Process:
GO:0007220
GO:0042987
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
T
E
L
P
A
P
L
S
Y
F
Q
N
A
Q
M
Site 2
S23
M
S
E
D
N
H
L
S
N
T
V
R
S
Q
N
Site 3
T25
E
D
N
H
L
S
N
T
V
R
S
Q
N
D
N
Site 4
S43
Q
E
H
N
D
R
R
S
L
G
H
P
E
P
L
Site 5
S51
L
G
H
P
E
P
L
S
N
G
R
P
Q
G
N
Site 6
S59
N
G
R
P
Q
G
N
S
R
Q
V
V
E
Q
D
Site 7
S102
V
V
V
A
T
I
K
S
V
S
F
Y
T
R
K
Site 8
S104
V
A
T
I
K
S
V
S
F
Y
T
R
K
D
G
Site 9
Y106
T
I
K
S
V
S
F
Y
T
R
K
D
G
Q
L
Site 10
Y115
R
K
D
G
Q
L
I
Y
T
P
F
T
E
D
T
Site 11
T116
K
D
G
Q
L
I
Y
T
P
F
T
E
D
T
E
Site 12
T122
Y
T
P
F
T
E
D
T
E
T
V
G
Q
R
A
Site 13
T124
P
F
T
E
D
T
E
T
V
G
Q
R
A
L
H
Site 14
Y154
T
I
L
L
V
V
L
Y
K
Y
R
C
Y
K
V
Site 15
T274
P
L
R
M
L
V
E
T
A
Q
E
R
N
E
T
Site 16
T281
T
A
Q
E
R
N
E
T
L
F
P
A
L
I
Y
Site 17
S310
P
E
A
Q
R
R
V
S
K
N
S
K
Y
N
A
Site 18
S313
Q
R
R
V
S
K
N
S
K
Y
N
A
E
S
T
Site 19
Y315
R
V
S
K
N
S
K
Y
N
A
E
S
T
E
R
Site 20
S319
N
S
K
Y
N
A
E
S
T
E
R
E
S
Q
D
Site 21
T320
S
K
Y
N
A
E
S
T
E
R
E
S
Q
D
T
Site 22
S324
A
E
S
T
E
R
E
S
Q
D
T
V
A
E
N
Site 23
T327
T
E
R
E
S
Q
D
T
V
A
E
N
D
D
G
Site 24
S337
E
N
D
D
G
G
F
S
E
E
W
E
A
Q
R
Site 25
S346
E
W
E
A
Q
R
D
S
H
L
G
P
H
R
S
Site 26
S353
S
H
L
G
P
H
R
S
T
P
E
S
R
A
A
Site 27
T354
H
L
G
P
H
R
S
T
P
E
S
R
A
A
V
Site 28
S357
P
H
R
S
T
P
E
S
R
A
A
V
Q
E
L
Site 29
S365
R
A
A
V
Q
E
L
S
S
S
I
L
A
G
E
Site 30
S366
A
A
V
Q
E
L
S
S
S
I
L
A
G
E
D
Site 31
S367
A
V
Q
E
L
S
S
S
I
L
A
G
E
D
P
Site 32
S401
G
K
A
S
A
T
A
S
G
D
W
N
T
T
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation