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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLK3
Full Name:
Dual specificity protein kinase CLK3
Alias:
CDC like kinase 3; EC 2.7.12.1
Type:
Protein-serine kinase, CMGC group, CLK family
Mass (Da):
58588
Number AA:
490
UniProt ID:
P49761
International Prot ID:
IPI00298896
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001669
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
CLKSelectide - CLK3 protein kinase substrate peptide - Powder PE-01BGW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BGW99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
L
A
D
H
A
G
S
G
R
R
S
G
P
S
Site 2
S21
H
A
G
S
G
R
R
S
G
P
S
P
T
A
R
Site 3
S24
S
G
R
R
S
G
P
S
P
T
A
R
S
G
P
Site 4
T26
R
R
S
G
P
S
P
T
A
R
S
G
P
H
L
Site 5
S29
G
P
S
P
T
A
R
S
G
P
H
L
S
A
L
Site 6
S34
A
R
S
G
P
H
L
S
A
L
R
A
Q
P
A
Site 7
S47
R
E
P
P
P
R
R
S
R
S
R
S
H
D
R
Site 8
T51
A
H
L
S
G
R
G
T
Y
V
R
R
D
T
A
Site 9
Y52
H
L
S
G
R
G
T
Y
V
R
R
D
T
A
G
Site 10
T57
G
T
Y
V
R
R
D
T
A
G
G
G
P
G
Q
Site 11
S74
P
L
G
P
P
G
T
S
L
L
G
R
G
A
R
Site 12
S83
L
G
R
G
A
R
R
S
G
E
G
W
C
P
G
Site 13
S94
W
C
P
G
A
F
E
S
G
A
R
A
A
R
P
Site 14
S103
A
R
A
A
R
P
P
S
R
V
E
P
R
L
A
Site 15
T111
R
V
E
P
R
L
A
T
A
A
S
R
E
G
A
Site 16
S114
P
R
L
A
T
A
A
S
R
E
G
A
G
L
P
Site 17
S129
R
A
E
V
A
A
G
S
G
R
G
A
R
S
G
Site 18
S135
S
S
K
R
S
S
R
S
V
E
D
D
K
E
G
Site 19
Y155
T
M
H
H
C
K
R
Y
R
S
P
E
P
D
P
Site 20
S157
H
H
C
K
R
Y
R
S
P
E
P
D
P
Y
L
Site 21
Y163
R
S
P
E
P
D
P
Y
L
S
Y
R
W
K
R
Site 22
S165
P
E
P
D
P
Y
L
S
Y
R
W
K
R
R
R
Site 23
Y166
E
P
D
P
Y
L
S
Y
R
W
K
R
R
R
S
Site 24
S173
Y
R
W
K
R
R
R
S
Y
S
R
E
H
E
G
Site 25
Y174
R
W
K
R
R
R
S
Y
S
R
E
H
E
G
R
Site 26
S175
W
K
R
R
R
S
Y
S
R
E
H
E
G
R
L
Site 27
Y184
E
H
E
G
R
L
R
Y
P
S
R
R
E
P
P
Site 28
S186
E
G
R
L
R
Y
P
S
R
R
E
P
P
P
R
Site 29
S195
R
E
P
P
P
R
R
S
R
S
R
S
H
D
R
Site 30
S197
P
P
P
R
R
S
R
S
R
S
H
D
R
L
P
Site 31
S199
P
R
R
S
R
S
R
S
H
D
R
L
P
Y
Q
Site 32
Y205
R
S
H
D
R
L
P
Y
Q
R
R
Y
R
E
R
Site 33
Y209
R
L
P
Y
Q
R
R
Y
R
E
R
R
D
S
D
Site 34
S215
R
Y
R
E
R
R
D
S
D
T
Y
R
C
E
E
Site 35
T217
R
E
R
R
D
S
D
T
Y
R
C
E
E
R
S
Site 36
Y218
E
R
R
D
S
D
T
Y
R
C
E
E
R
S
P
Site 37
S224
T
Y
R
C
E
E
R
S
P
S
F
G
E
D
Y
Site 38
S226
R
C
E
E
R
S
P
S
F
G
E
D
Y
Y
G
Site 39
Y231
S
P
S
F
G
E
D
Y
Y
G
P
S
R
S
R
Site 40
Y232
P
S
F
G
E
D
Y
Y
G
P
S
R
S
R
H
Site 41
S237
D
Y
Y
G
P
S
R
S
R
H
R
R
R
S
R
Site 42
S243
R
S
R
H
R
R
R
S
R
E
R
G
P
Y
R
Site 43
Y249
R
S
R
E
R
G
P
Y
R
T
R
K
H
A
H
Site 44
T251
R
E
R
G
P
Y
R
T
R
K
H
A
H
H
C
Site 45
T263
H
H
C
H
K
R
R
T
R
S
C
S
S
A
S
Site 46
S265
C
H
K
R
R
T
R
S
C
S
S
A
S
S
R
Site 47
S267
K
R
R
T
R
S
C
S
S
A
S
S
R
S
Q
Site 48
S268
R
R
T
R
S
C
S
S
A
S
S
R
S
Q
Q
Site 49
S270
T
R
S
C
S
S
A
S
S
R
S
Q
Q
S
S
Site 50
S271
R
S
C
S
S
A
S
S
R
S
Q
Q
S
S
K
Site 51
S273
C
S
S
A
S
S
R
S
Q
Q
S
S
K
R
S
Site 52
S276
A
S
S
R
S
Q
Q
S
S
K
R
S
S
R
S
Site 53
S277
S
S
R
S
Q
Q
S
S
K
R
S
S
R
S
V
Site 54
S280
S
Q
Q
S
S
K
R
S
S
R
S
V
E
D
D
Site 55
S281
Q
Q
S
S
K
R
S
S
R
S
V
E
D
D
K
Site 56
S283
S
S
K
R
S
S
R
S
V
E
D
D
K
E
G
Site 57
Y304
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
Site 58
T314
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
Site 59
S329
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
Site 60
Y342
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
Site 61
T391
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
Site 62
Y403
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
Site 63
T428
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
Site 64
T446
F
V
N
S
E
F
E
T
L
Y
N
E
H
K
S
Site 65
Y448
N
S
E
F
E
T
L
Y
N
E
H
K
S
C
E
Site 66
S453
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
Site 67
S458
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
Site 68
S463
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
Site 69
S471
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
Site 70
T473
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
Site 71
T524
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
Site 72
S543
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
Site 73
Y554
H
R
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
Site 74
S567
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
Site 75
Y571
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
Site 76
S581
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
Site 77
S587
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
Site 78
T624
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
Site 79
S629
G
L
T
P
E
E
R
S
F
H
T
S
R
N
P
Site 80
T632
P
E
E
R
S
F
H
T
S
R
N
P
S
R
_
Site 81
S633
E
E
R
S
F
H
T
S
R
N
P
S
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation