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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCM2
Full Name:
DNA replication licensing factor MCM2
Alias:
BM28; CDCL1; DNA replication licensing factor MCM2; KIAA0030; MCMD2; Minichromosome maintenance protein 2 homologue
Type:
DNA binding protein
Mass (Da):
101896
Number AA:
904
UniProt ID:
P49736
International Prot ID:
IPI00184330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006270
GO:0007049
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
E
S
S
E
S
F
T
M
A
Site 2
S5
_
_
_
M
A
E
S
S
E
S
F
T
M
A
S
Site 3
S7
_
M
A
E
S
S
E
S
F
T
M
A
S
S
P
Site 4
T9
A
E
S
S
E
S
F
T
M
A
S
S
P
A
Q
Site 5
S12
S
E
S
F
T
M
A
S
S
P
A
Q
R
R
R
Site 6
S13
E
S
F
T
M
A
S
S
P
A
Q
R
R
R
G
Site 7
T25
R
R
G
N
D
P
L
T
S
S
P
G
R
S
S
Site 8
S26
R
G
N
D
P
L
T
S
S
P
G
R
S
S
R
Site 9
S27
G
N
D
P
L
T
S
S
P
G
R
S
S
R
R
Site 10
S31
L
T
S
S
P
G
R
S
S
R
R
T
D
A
L
Site 11
S32
T
S
S
P
G
R
S
S
R
R
T
D
A
L
T
Site 12
T35
P
G
R
S
S
R
R
T
D
A
L
T
S
S
P
Site 13
T39
S
R
R
T
D
A
L
T
S
S
P
G
R
D
L
Site 14
S40
R
R
T
D
A
L
T
S
S
P
G
R
D
L
P
Site 15
S41
R
T
D
A
L
T
S
S
P
G
R
D
L
P
P
Site 16
S53
L
P
P
F
E
D
E
S
E
G
L
L
G
T
E
Site 17
T59
E
S
E
G
L
L
G
T
E
G
P
L
E
E
E
Site 18
Y81
G
D
G
M
E
R
D
Y
R
A
I
P
E
L
D
Site 19
T106
D
E
D
V
E
E
L
T
A
S
Q
R
E
A
A
Site 20
S108
D
V
E
E
L
T
A
S
Q
R
E
A
A
E
R
Site 21
Y137
R
M
R
R
G
L
L
Y
D
S
D
E
E
D
E
Site 22
S139
R
R
G
L
L
Y
D
S
D
E
E
D
E
E
R
Site 23
T158
R
R
Q
V
E
R
A
T
E
D
G
E
E
D
E
Site 24
S170
E
D
E
E
M
I
E
S
I
E
N
L
E
D
L
Site 25
S181
L
E
D
L
K
G
H
S
V
R
E
W
V
S
M
Site 26
T205
R
F
K
N
F
L
R
T
H
V
D
S
H
G
H
Site 27
S220
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Site 28
S229
M
C
K
E
N
R
E
S
L
V
V
N
Y
E
D
Site 29
Y274
V
L
A
M
Y
P
K
Y
D
R
I
T
N
H
I
Site 30
S286
N
H
I
H
V
R
I
S
H
L
P
L
V
E
E
Site 31
S296
P
L
V
E
E
L
R
S
L
R
Q
L
H
L
N
Site 32
Y327
P
Q
L
S
M
V
K
Y
N
C
N
K
C
N
F
Site 33
S342
V
L
G
P
F
C
Q
S
Q
N
Q
E
V
K
P
Site 34
S351
N
Q
E
V
K
P
G
S
C
P
E
C
Q
S
A
Site 35
S357
G
S
C
P
E
C
Q
S
A
G
P
F
E
V
N
Site 36
Y370
V
N
M
E
E
T
I
Y
Q
N
Y
Q
R
I
R
Site 37
Y373
E
E
T
I
Y
Q
N
Y
Q
R
I
R
I
Q
E
Site 38
S381
Q
R
I
R
I
Q
E
S
P
G
K
V
A
A
G
Site 39
T415
P
G
D
E
I
E
L
T
G
I
Y
H
N
N
Y
Site 40
Y418
E
I
E
L
T
G
I
Y
H
N
N
Y
D
G
S
Site 41
Y422
T
G
I
Y
H
N
N
Y
D
G
S
L
N
T
A
Site 42
S466
E
D
V
K
M
I
T
S
L
S
K
D
Q
Q
I
Site 43
S468
V
K
M
I
T
S
L
S
K
D
Q
Q
I
G
E
Site 44
T527
L
L
C
G
D
P
G
T
A
K
S
Q
F
L
K
Site 45
S530
G
D
P
G
T
A
K
S
Q
F
L
K
Y
I
E
Site 46
Y535
A
K
S
Q
F
L
K
Y
I
E
K
V
S
S
R
Site 47
S540
L
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
Site 48
S541
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
G
Site 49
S566
Y
V
Q
R
H
P
V
S
R
E
W
T
L
E
A
Site 50
T570
H
P
V
S
R
E
W
T
L
E
A
G
A
L
V
Site 51
S608
H
E
A
M
E
Q
Q
S
I
S
I
S
K
A
G
Site 52
S612
E
Q
Q
S
I
S
I
S
K
A
G
I
V
T
S
Site 53
Y637
A
N
P
I
G
G
R
Y
D
P
S
L
T
F
S
Site 54
S640
I
G
G
R
Y
D
P
S
L
T
F
S
E
N
V
Site 55
T642
G
R
Y
D
P
S
L
T
F
S
E
N
V
D
L
Site 56
S644
Y
D
P
S
L
T
F
S
E
N
V
D
L
T
E
Site 57
T650
F
S
E
N
V
D
L
T
E
P
I
I
S
R
F
Site 58
S682
L
A
R
F
V
V
G
S
H
V
R
H
H
P
S
Site 59
S689
S
H
V
R
H
H
P
S
N
K
E
E
E
G
L
Site 60
T709
A
E
P
A
M
P
N
T
Y
G
V
E
P
L
P
Site 61
Y723
P
Q
E
V
L
K
K
Y
I
I
Y
A
K
E
R
Site 62
S748
D
K
V
A
K
M
Y
S
D
L
R
K
E
S
M
Site 63
S754
Y
S
D
L
R
K
E
S
M
A
T
G
S
I
P
Site 64
T757
L
R
K
E
S
M
A
T
G
S
I
P
I
T
V
Site 65
S769
I
T
V
R
H
I
E
S
M
I
R
M
A
E
A
Site 66
Y785
A
R
I
H
L
R
D
Y
V
I
E
D
D
V
N
Site 67
S801
A
I
R
V
M
L
E
S
F
I
D
T
Q
K
F
Site 68
T805
M
L
E
S
F
I
D
T
Q
K
F
S
V
M
R
Site 69
S813
Q
K
F
S
V
M
R
S
M
R
K
T
F
A
R
Site 70
T817
V
M
R
S
M
R
K
T
F
A
R
Y
L
S
F
Site 71
Y821
M
R
K
T
F
A
R
Y
L
S
F
R
R
D
N
Site 72
S823
K
T
F
A
R
Y
L
S
F
R
R
D
N
N
E
Site 73
Y846
L
V
A
E
Q
V
T
Y
Q
R
N
R
F
G
A
Site 74
T857
R
F
G
A
Q
Q
D
T
I
E
V
P
E
K
D
Site 75
S878
Q
I
N
I
H
N
L
S
A
F
Y
D
S
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation