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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CSNK1E
Full Name:
Casein kinase I isoform epsilon
Alias:
Casein kinase 1, epsilon; CKIe; CKI-epsilon; EC 2.7.11.1; KC1E
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family
Mass (Da):
47315
Number AA:
416
UniProt ID:
P49674
International Prot ID:
IPI00027729
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
E
L
R
V
G
N
K
Y
R
L
G
R
K
I
G
Site 2
S17
R
L
G
R
K
I
G
S
G
S
F
G
D
I
Y
Site 3
S19
G
R
K
I
G
S
G
S
F
G
D
I
Y
L
G
Site 4
T44
I
K
L
E
C
V
K
T
K
H
P
Q
L
H
I
Site 5
Y56
L
H
I
E
S
K
F
Y
K
M
M
Q
G
G
V
Site 6
S97
E
D
L
F
N
F
C
S
R
K
F
S
L
K
T
Site 7
Y118
Q
M
I
S
R
I
E
Y
I
H
S
K
N
F
I
Site 8
Y156
D
F
G
L
A
K
K
Y
R
D
A
R
T
H
Q
Site 9
T161
K
K
Y
R
D
A
R
T
H
Q
H
I
P
Y
R
Site 10
T176
E
N
K
N
L
T
G
T
A
R
Y
A
S
I
N
Site 11
S181
T
G
T
A
R
Y
A
S
I
N
T
H
L
G
I
Site 12
S191
T
H
L
G
I
E
Q
S
R
R
D
D
L
E
S
Site 13
S198
S
R
R
D
D
L
E
S
L
G
Y
V
L
M
Y
Site 14
Y225
A
A
T
K
R
Q
K
Y
E
R
I
S
E
K
K
Site 15
S229
R
Q
K
Y
E
R
I
S
E
K
K
M
S
T
P
Site 16
S234
R
I
S
E
K
K
M
S
T
P
I
E
V
L
C
Site 17
T235
I
S
E
K
K
M
S
T
P
I
E
V
L
C
K
Site 18
Y244
I
E
V
L
C
K
G
Y
P
S
E
F
S
T
Y
Site 19
T250
G
Y
P
S
E
F
S
T
Y
L
N
F
C
R
S
Site 20
Y251
Y
P
S
E
F
S
T
Y
L
N
F
C
R
S
L
Site 21
S257
T
Y
L
N
F
C
R
S
L
R
F
D
D
K
P
Site 22
Y266
R
F
D
D
K
P
D
Y
S
Y
L
R
Q
L
F
Site 23
S267
F
D
D
K
P
D
Y
S
Y
L
R
Q
L
F
R
Site 24
Y268
D
D
K
P
D
Y
S
Y
L
R
Q
L
F
R
N
Site 25
Y286
R
Q
G
F
S
Y
D
Y
V
F
D
W
N
M
L
Site 26
S323
R
M
G
Q
L
R
G
S
A
T
R
A
L
P
P
Site 27
T325
G
Q
L
R
G
S
A
T
R
A
L
P
P
G
P
Site 28
T334
A
L
P
P
G
P
P
T
G
A
T
A
N
R
L
Site 29
T337
P
G
P
P
T
G
A
T
A
N
R
L
R
S
A
Site 30
S343
A
T
A
N
R
L
R
S
A
A
E
P
V
A
S
Site 31
S350
S
A
A
E
P
V
A
S
T
P
A
S
R
I
Q
Site 32
T351
A
A
E
P
V
A
S
T
P
A
S
R
I
Q
P
Site 33
S354
P
V
A
S
T
P
A
S
R
I
Q
P
A
G
N
Site 34
T362
R
I
Q
P
A
G
N
T
S
P
R
A
I
S
R
Site 35
S363
I
Q
P
A
G
N
T
S
P
R
A
I
S
R
V
Site 36
S368
N
T
S
P
R
A
I
S
R
V
D
R
E
R
K
Site 37
S377
V
D
R
E
R
K
V
S
M
R
L
H
R
G
A
Site 38
S389
R
G
A
P
A
N
V
S
S
S
D
L
T
G
R
Site 39
S390
G
A
P
A
N
V
S
S
S
D
L
T
G
R
Q
Site 40
S391
A
P
A
N
V
S
S
S
D
L
T
G
R
Q
E
Site 41
T394
N
V
S
S
S
D
L
T
G
R
Q
E
V
S
R
Site 42
S400
L
T
G
R
Q
E
V
S
R
I
P
A
S
Q
T
Site 43
S405
E
V
S
R
I
P
A
S
Q
T
S
V
P
F
D
Site 44
T407
S
R
I
P
A
S
Q
T
S
V
P
F
D
H
L
Site 45
S408
R
I
P
A
S
Q
T
S
V
P
F
D
H
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation